Active Recombinant Full Length Human IRAK4 Protein, DDK-tagged, Biotinylated

• Cat.No.: IRAK4-9963HF
• Product Overview: Full-length human IRAK4 [1-460(end) amino acids of accession number NP_057207.2] was expressed as N-terminal DYKDDDDK tagged, biotinylated protein (55 kDa) using baculovirus expression system. The protein was purified by using DYKDDDDK tag antibody agarose.

Specification

• Source: Insect (sf21)
• Species: Human
• Tag: Flag
• Form: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
• Bio-activity: The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorecence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip™3000.
• Protein length: 1-460(end)
• Purity: 91%
• Applications: SDS-PAGE
• Storage: Store at -80C. Avoid repeating freeze-thaws.

Gene Information

• Gene Name: interleukin-1 receptor-associated kinase 4
• Official Symbol: IRAK4
• Synonyms: IRAK4;IPD1;IRAK-4;NY-REN-64;REN64
• Protein Refseq: NP_057207.2
• UniProt ID: Q9NWZ3

Reviews

11/16/2021

Its potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.

03/01/2020

Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.

07/16/2018

They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.

Q&As

What conditions are associated with IRAK4 dysregulation?

Rheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.

Are there any ongoing clinical trials involving IRAK4 inhibitors?

Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.

What are the methods used to target IRAK4 in treatment?

Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.

How does the expression of IRAK4 differ in healthy individuals and those with autoimmune diseases?

Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.

How does IRAK4 inhibition impact the immune response?

By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.