IRAK4 involved in several pathways and played different roles in them. We selected most pathways IRAK4 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| NF-kappa B signaling pathway |
LYN; BIRC2; PLCG2; MYD88; TNFSF11; PTGS2; TNFSF14; Bcl2a1b; BCL2A1; GADD45B |
| Apoptosis |
CLSPN; FAS; DSG3; CASP8; BCL2; CASP6L2; IL1A; CTNNB1; CAPN2A; BNIP3L |
| Toll-like receptor signaling pathway |
TNF; CD14; CXCL9; IRF7; PIK3CA; IFNA14; MAPK11; IFNA13; NFKBIAB; FOS |
| Neurotrophin signaling pathway |
YWHAE; PIK3R1; IRAK1; PIK3R2; SH2B1; ARHGDIG; MAPK1; PRKCD; CALM2; RAPGEF1 |
| Pertussis |
MYD88; MAPK13; IRAK1; CFL2; CALML3; C2; Casp3; CXCL6; CALM1; TICAM2 |
| Leishmaniasis |
FCGR2C; IFNGR2; TNF; NCF4; FCGR3; PTPN6; HLA-DRB3; NFKB1; HLA-DQA1; TGFB2 |
| Chagas disease (American trypanosomiasis) |
TLR9; FADD; TNFRSF1A; SMAD3; TLR4; GNAI2; SMAD2; GNAI1; TLR2; PIK3R5 |
| Toxoplasmosis |
TGFB3; HLA-DRB5; BIRC2; IKBKG; IRAK1; PDPK1; LAMA5; NFKB1; HLA-DRA; PIK3CD |
| Tuberculosis |
HSPA9; FCGR3B; FCGR3A; BID; HLA-DPB1; FCER1G; ITGAM; LSP1; CLEC7A; HLA-DQB1 |
| Measles |
TACR1; IL2RG; IFNA1; IFNA2; STAT3; IL12A; TNFRSF10A; TLR9; TNFAIP3; HSPA8 |
| Influenza A |
HLA-DOA; H2-AA; STAT2; TYK2; MAPK10; HLA-DQA2; PIK3R5; MAPK11; IFNA14; Ccl12 |
IRAK4 has several biochemical functions, for example, ATP binding, interleukin-1 receptor binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK4 itself. We selected most functions IRAK4 had, and list some proteins which have the same functions with IRAK4. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
ULK4; PIM1; PIP5K2; PNKP; NLK; PKN1B; ABCC2; DDX59; ATAD2; PEBP1 |
| interleukin-1 receptor binding |
IL36A; IL1F10; IL1B; IL1RN; IRAK4; IL1RAP; TLR5; IL36B; IRAK1; TLR9 |
| magnesium ion binding |
DYRK2; FDXACB1; GEM; GLUL; MTHFD2; STK11; NUDT7; NT5C1B; HPGDS; WEE2 |
| protein binding |
KPNA3; SNTA1; ZBED4; DUSP21; ZSCAN16; BRE; USP34; MATN2; KRT38; NLRP12 |
| protein kinase activity |
INSRB; IGF1RB; LIMK1A; CDK9; PDPK1A; MAPK14B; PRKCD; PANK1A; PDGFRA; Aatk |
| protein serine/threonine kinase activity |
ULK1A; TSSK1; RAF1B; NEK12; DAPK1; TSSK4; SMG1; DYRK4; CDK11B; DSTYK |
IRAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK4.
PELI2; IRAK1; TIRAP; PELI1; TNFRSF13B; IL1RL1; Irak3; ARNT; TBPL1; MYD88; IRAK2; KIF11
Cushing, L; Stochaj, W; et al. Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner. JOURNAL OF BIOLOGICAL CHEMISTRY 289:10865-10875(2014).
Jang, SE; Hyam, SR; et al. Penta-O-galloyl-beta-D-glucose ameliorates inflammation by inhibiting MyD88/NF-kappa B and MyD88/MAPK signalling pathways. BRITISH JOURNAL OF PHARMACOLOGY 170:1078-1091(2013).
