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  • Official Full Name

    interleukin-1 receptor-associated kinase 4

  • Overview

    IRAK-4 is a member of the interleukin-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon phosphorylation, IRAK-4 interacts with IRAK-1, MYD88 and TRAF6 to form a complex, and activate NF-kB and MAPK pathways (2-3). IRAK-4 phosphorylates and activates IRAK-1 at thr387 and is also known to interact with IRAK-1 but not with the other IRAK members. Additionally, like IRAK-1, IRAK-4 possesses an auto and crossphosphorylation kinase activity (4).
  • Synonyms

    IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRAK4-46H Active Recombinant Human IRAK4 protein, His-tagged Insect Cell His
Human IRAK4-1418H Active Recombinant Human IRAK4, GST-tagged Sf9 Insect Cell GST Full length
Human IRAK4-81HFL Active Recombinant Full Length Human IRAK4 Protein, N-His-tagged Sf21 His Full Length
Human IRAK4-7074H Recombinant Human IRAK4 protein, His-tagged E.coli His Gly189~Glu427
Human IRAK4-27000TH Recombinant Human IRAK4 N/A
Human IRAK4-54H Recombinant Human IRAK4 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human IRAK4-5437H Recombinant Human Interleukin-1 Receptor-Associated Kinase 4, His-tagged Insect Cell His
Human IRAK4-615HCL Recombinant Human IRAK4 cell lysate Insect Cell N/A
Human IRAK4-2438H Recombinant Full Length Human IRAK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IRAK4-058H Recombinant Human IRAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human IRAK4-9963HF Active Recombinant Full Length Human IRAK4 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-460(end)
Human IRAK4-2695HF Active Recombinant Full Length Human IRAK4 Protein, GST-tagged Insect (sf21) GST 1-460(end)
Human IRAK4-5049H Recombinant Human IRAK4 Protein, GST-tagged Wheat Germ GST
Human IRAK4-2707H Recombinant Human IRAK4 Protein (Met1-Val200), N-His tagged E.coli N-His Met1-Val200
Human IRAK4-940HFL Recombinant Full Length Human IRAK4 Protein, C-Flag-tagged Mammalian cells Flag
Human IRAK4-05HF Recombinant Full Length Human IRAK4 Protein, N-His tagged E.coli N-His
Human IRAK4-5733HF Recombinant Full Length Human IRAK4 Protein, GST-tagged In Vitro Cell Free System GST 460 amino acids
Human IRAK4-1107H Recombinant Human IRAK4 protein(Met1-Ser336), His-tagged Insect Cells C-His Met1-Ser336
Human IRAK4-1193H-B Recombinant Human IRAK4 Protein Pre-coupled Magnetic Beads HEK293
Human IRAK4-1193H Recombinant Human IRAK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IRAK4-1168H Recombinant Human IRAK4 Protein (E154-S460), Tag Free Insect Cell No tag E154-S460
Human IRAK4-1169H Recombinant Human IRAK4 Protein (E154-S460), His tagged Insect Cell His E154-S460
Human IRAK4-35H Recombinant Human IRAK4 Protein, His tagged E.coli C-His
Mouse IRAK4-8295M Recombinant Mouse IRAK4 Protein Mammalian Cell His
Mouse Irak4-3570M Recombinant Mouse Irak4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse IRAK4-4597M-B Recombinant Mouse IRAK4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Irak4-0058M Recombinant Mouse Irak4 protein(Ser169-Ala459), His-tagged E.coli N-His Ser169-Ala459
Mouse IRAK4-4597M Recombinant Mouse IRAK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Irak4-0057M Recombinant Mouse Irak4 Protein (Met1-Ala459), C-His-tagged Baculovirus-Insect cells C-His Met1-Ala459
Rhesus Macaque IRAK4-2291R Recombinant Rhesus monkey IRAK4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IRAK4-2112R Recombinant Rhesus Macaque IRAK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IRAK4-2112R-B Recombinant Rhesus Macaque IRAK4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IRAK4-10510Z Recombinant Zebrafish IRAK4 Mammalian Cell His
Chicken IRAK4-2439C Recombinant Chicken IRAK4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IRAK4 Related Articles
  • IRAK4 Related Research Area

IRAK4 involved in several pathways and played different roles in them. We selected most pathways IRAK4 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Toll-like receptor signaling pathwayPIK3CB;PIK3R5;CCL3L3;IRF7;MAPK12A;MAP2K2A;TLR1LB;CXCL11;MAP2K2
Neurotrophin signaling pathwayPIK3CB;NGFR;RAF1;NTRK3;PDPK1;MAP3K5;MAPK12;PTPN11;CALM4
PertussisTICAM2;Il23a; Il12b;GNAI1;FOS;MAPK12;IL1A;PYCARD;IL12B;C4BP
Chagas disease (American trypanosomiasis)TNF;PPP2R2C;SMAD3;CFLAR;IL1B;FAS;CXCL8;TLR2;SMAD2

IRAK4 has several biochemical functions, for example, ATP binding, interleukin-1 receptor binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK4 itself. We selected most functions IRAK4 had, and list some proteins which have the same functions with IRAK4. You can find most of the proteins on our site.

Function Related Protein
interleukin-1 receptor bindingIRAK4;TLR5;IRAK1;IL1A;IL1B;IL36G;TLR9;IL36B;TRIP6
protein kinase activityPKMYT1;KSR1;EPHB2B;JAK2B;MAP2K5;OXSR1B;ACVR1L;NPR1;NIM1
protein serine/threonine kinase activityMAP2K2A;STK39;PKMYT1;DYRK3;PRKAA2;TNK2;CAMK2D;KALRN;MKNK1

IRAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK4.


Cushing, L; Stochaj, W; et al. Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner. JOURNAL OF BIOLOGICAL CHEMISTRY 289:10865-10875(2014).
Jang, SE; Hyam, SR; et al. Penta-O-galloyl-beta-D-glucose ameliorates inflammation by inhibiting MyD88/NF-kappa B and MyD88/MAPK signalling pathways. BRITISH JOURNAL OF PHARMACOLOGY 170:1078-1091(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
What conditions are associated with IRAK4 dysregulation? 11/04/2020

Rheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.

Are there any ongoing clinical trials involving IRAK4 inhibitors? 10/07/2020

Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.

What are the methods used to target IRAK4 in treatment? 11/25/2017

Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.

How does the expression of IRAK4 differ in healthy individuals and those with autoimmune diseases? 11/01/2016

Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.

How does IRAK4 inhibition impact the immune response? 01/17/2016

By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.

Customer Reviews (3)

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    Its potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.


      Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.


        They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.

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