IRAK4 Protein


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Official Full Name interleukin-1 receptor-associated kinase 4
Background IRAK-4 is a member of the interleukin-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon phosphorylation, IRAK-4 interacts with IRAK-1, MYD88 and TRAF6 to form a complex, and activate NF-kB and MAPK pathways (2-3). IRAK-4 phosphorylates and activates IRAK-1 at thr387 and is also known to interact with IRAK-1 but not with the other IRAK members. Additionally, like IRAK-1, IRAK-4 possesses an auto and crossphosphorylation kinase activity (4).
Synonyms IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Insect (sf21)
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • BTN
    • C-Myc/DDK
    • Flag
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRAK4-1418H Recombinant Human IRAK4 (Active), GST-tagged Sf9 Insect Cell GST
    Human IRAK4-46H Recombinant Human IRAK4 protein, His-tagged Insect Cell His
    Human IRAK4-27000TH Recombinant Human IRAK4 N/A
    Human IRAK4-5437H Recombinant Human Interleukin-1 Receptor-Associated Kinase 4, His-tagged Insect Cell His
    Human IRAK4-54H Recombinant Human IRAK4 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human IRAK4-7074H Recombinant Human IRAK4 protein, His-tagged E.coli His
    Mouse IRAK4-8295M Recombinant Mouse IRAK4 Protein Mammalian Cell His
    Rhesus Macaque IRAK4-2291R Recombinant Rhesus monkey IRAK4 Protein, His-tagged Mammalian Cell His
    Chicken IRAK4-2439C Recombinant Chicken IRAK4 Mammalian Cell His
    Zebrafish IRAK4-10510Z Recombinant Zebrafish IRAK4 Mammalian Cell His
    Human IRAK4-615HCL Recombinant Human IRAK4 cell lysate Insect Cell N/A
    Human IRAK4-2695HF Recombinant Full Length Human IRAK4 Protein, GST-tagged Insect (sf21) GST
    Human IRAK4-5733HF Recombinant Full Length Human IRAK4 Protein, GST-tagged In Vitro Cell Free System GST
    Human IRAK4-9963HF Recombinant Full Length Human IRAK4 Protein, BTN-tagged Insect (sf21) BTN
    Human IRAK4-058H Recombinant Human IRAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human IRAK4-2438H Recombinant Human IRAK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IRAK4-5049H Recombinant Human IRAK4 Protein, GST-tagged Wheat Germ GST
    Mouse Irak4-3570M Recombinant Mouse Irak4 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    IRAK4 involved in several pathways and played different roles in them. We selected most pathways IRAK4 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway ZAP70; PLCG2; LAT; IL1B; TRAF6; BCL2; TRAF5; XIAP; LRDD; CFLAR
    Apoptosis Fasl; PRKAR2A; PRKAR2AA; HIST1H1D; CAPN1A; IL3; BAX; PPP3CC; CASP10; H1F0
    Toll-like receptor signaling pathway MAP2K3; CD86; MAP2K4A; CXCL10; TLR4; PIK3R3B; TLR1LA; CCL3; TLR2-2; STAT1
    Neurotrophin signaling pathway MAPK10; TP53; PIK3R3; HRAS; MAPKAPK2; MAP3K1; SH2B2; NFKB1; MAP3K3; IRAK2
    Pertussis C1QC; ITGB2L; MAPK10; IL12B; RELA; IRF1; MAPK13; Itgam&Itgb2; PYCARD; IRF3
    Leishmaniasis MAPK12; FCGR3B; HLA-DMA; FCGR2A; HLA-DRB5; Itgam&Itgb2; FCGR4; MARCKSL1; FCGR3; CR1
    Chagas disease (American trypanosomiasis) CD3E; CD3D; TLR4; ACE; PPP2R1A; CXCL8; CCL3L1; RELA; IFNGR2; PPP2CA; FOS
    Toxoplasmosis MAPK1; TNF; PDPK1; LAMA4; TGFB1; TGFB2; LAMA2; PIK3R5; H2-AB1; AKT2
    Tuberculosis C3; FCGR1; IFNA12; PIK3C3; IFNA8; NOS2; FCGR3; HSPD1; CALM3; CAMK2B
    Measles PIK3CB; TNFRSF10B; IFNA12; HSPA1A; IFNG; IL2RB; PIK3R2; CD209C; Ifna11; IFNA1

    IRAK4 has several biochemical functions, for example, ATP binding, interleukin-1 receptor binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK4 itself. We selected most functions IRAK4 had, and list some proteins which have the same functions with IRAK4. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-1 receptor binding IL1RAP; IL1F10; IL1B; IRAK4; TRIP6; IL36B; IL36A; IL37; IL1A; IL36G
    magnesium ion binding SRPK2; ATP11C; COMT; EYA2; PPM1N; PPA2; COMTB; GTPBP5; PPM1AA; S100P
    protein binding ARMCX1; HTATIP2; KAT2A; SRGAP2; KATNA1; HEBP2; RPL22; FBXW11; HOXC4; TTK
    protein kinase activity CDK11A; RPS6KB1B; POMK; SCYL1; NRBP1; TSSK1; EPHA4; TNNI3K; AKT2L; MAPK14B
    protein serine/threonine kinase activity ROCK1; CDC42BPA; BUB1B; RPS6KA3B; OXSR1B; AKT2; NLK; DMPK; TNK2; VRK2

    IRAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK4.


    Cushing, L; Stochaj, W; et al. Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner. JOURNAL OF BIOLOGICAL CHEMISTRY 289:10865-10875(2014).
    Jang, SE; Hyam, SR; et al. Penta-O-galloyl-beta-D-glucose ameliorates inflammation by inhibiting MyD88/NF-kappa B and MyD88/MAPK signalling pathways. BRITISH JOURNAL OF PHARMACOLOGY 170:1078-1091(2013).

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