IRAK4

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IRAK4

Official Full Name interleukin-1 receptor-associated kinase 4
Background IRAK-4 is a member of the interleukin-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon phosphorylation, IRAK-4 interacts with IRAK-1, MYD88 and TRAF6 to form a complex, and activate NF-kB and MAPK pathways (2-3). IRAK-4 phosphorylates and activates IRAK-1 at thr387 and is also known to interact with IRAK-1 but not with the other IRAK members. Additionally, like IRAK-1, IRAK-4 possesses an auto and crossphosphorylation kinase activity (4).
Synonyms IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • Flag
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRAK4-058H Recombinant Human IRAK4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human IRAK4-1418H Recombinant Human IRAK4 (Active), GST-tagged Sf9 Insect Cell GST
    Human IRAK4-2438H Recombinant Human IRAK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IRAK4-27000TH Recombinant Human IRAK4 N/A
    Human IRAK4-46H Recombinant Human IRAK4 protein, His-tagged Insect Cell His
    Human IRAK4-5049H Recombinant Human IRAK4 Protein, GST-tagged Wheat Germ GST
    Human IRAK4-5437H Recombinant Human Interleukin-1 Receptor-Associated Kinase 4, His-tagged Insect Cell His
    Human IRAK4-54H Recombinant Human IRAK4 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human IRAK4-615HCL Recombinant Human IRAK4 cell lysate Insect Cell N/A
    Human IRAK4-7074H Recombinant Human IRAK4 protein, His-tagged E.coli His
    Mouse Irak4-3570M Recombinant Mouse Irak4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse IRAK4-8295M Recombinant Mouse IRAK4 Protein Mammalian Cell His
    Rhesus Macaque IRAK4-2291R Recombinant Rhesus monkey IRAK4 Protein, His-tagged Mammalian Cell His
    Chicken IRAK4-2439C Recombinant Chicken IRAK4 Mammalian Cell His
    Zebrafish IRAK4-10510Z Recombinant Zebrafish IRAK4 Mammalian Cell His

    IRAK4 involved in several pathways and played different roles in them. We selected most pathways IRAK4 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway BLNK; MAP3K7IP3; IRAK1; PIDD1; MYD88; PRKCB; PRKCQ; GM13304; ICAM1; CCL13
    Apoptosis HIST1H1A; OCLN; PIK3R3A; NFKBIAB; BIDA; BIRC2; DYNLL2; PRKAR2AA; DNM1L; PIK3R3
    Toll-like receptor signaling pathway TRAF6; MAPK11; TLR8; TLR4BA; CCL5; TLR2; PIK3R3; PIK3CA; MAPK8A; PIK3R2
    Neurotrophin signaling pathway NFKB1; MAP2K7; RAPGEF1; NGFR; KIDINS220; TP73; RAP1A; PSEN2; BRAF; FOXO3
    Pertussis RHOA; GM5077; CALM1; IL12B; SERPING1; GNAI2; IL6; CALM4; Il23a; Casp3
    Leishmaniasis TRAF6; HLA-DRB4; TGFB1; MAP3K7; FCGR3A; IRAK4; FOS; FCGR4; HLA-DMB; TNF
    Chagas disease (American trypanosomiasis) FAS; MAPK13; BDKRB2; IL12B; IL-8; TRAF6; CCL2; PIK3R1; SERPINE1; PPP2R2A
    Toxoplasmosis LAMC2; IRAK1; Toxoplasma Gondii Profilin Family Protein; PIK3CD; IRGM; MAPK12; HLA-DMB; LAMA5; LY96; IKBKG
    Tuberculosis IL6; Itgam&Itgb2; AKT2; ATP6V0C; PIK3C3; VDR; LAMP1; FADD; KSR1; MAPK1
    Measles TBK1; IFNA7; IKBKE; CD28; EIF3H; IFNA8; IFNA1; IFNAR2; MSN; CCNE2
    Influenza A DDX39B; TNF; CASP9; PABPN1L; FASLG; PRKCB; NXF1; RELA; EP300; HLA-DRB3

    IRAK4 has several biochemical functions, for example, ATP binding, interleukin-1 receptor binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK4 itself. We selected most functions IRAK4 had, and list some proteins which have the same functions with IRAK4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DDX25; NME1; MAT1A; MAP3K10; CHD7; PAN3; PDK4; CPS1; PDIK1L; DMC1
    interleukin-1 receptor binding IRAK1; IL36B; TLR5; IL1A; IL37; IRAK4; TRIP6; IL1RAP; IL1RN; TLR9
    magnesium ion binding NT5C1B; TSSK2; SERPINB1A; HPGDS; SRR; CDC42BPG; ATP4A; ICK; SIK3; MARK1
    protein binding HSP90AA1.1; CD59; GSK3B; KRTAP12-1; NLRP2; TSKS; CSF2RA; MCM7; FAM71C; NLGN3
    protein kinase activity MAPKAPK2A; ADRBK1; RBM4.3; LTK; CLK2B; ACVR1; PRKACAB; GUCY2E; PKN3; STK25A
    protein serine/threonine kinase activity RPS6KC1; EIF2AK2; MAPK4; CSNK1A1L; TESK2; CDK11B; BMPR1BA; PIK3CA; MAP2K7; NLK

    IRAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK4.

    PELI2; IRAK1; TIRAP; PELI1; TNFRSF13B; IL1RL1; Irak3; ARNT; TBPL1; MYD88; IRAK2; KIF11

    Cushing, L; Stochaj, W; et al. Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner. JOURNAL OF BIOLOGICAL CHEMISTRY 289:10865-10875(2014).
    Jang, SE; Hyam, SR; et al. Penta-O-galloyl-beta-D-glucose ameliorates inflammation by inhibiting MyD88/NF-kappa B and MyD88/MAPK signalling pathways. BRITISH JOURNAL OF PHARMACOLOGY 170:1078-1091(2013).

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