Recombinant Human LRP1 Protein

• Cat.No.: LRP1-4698H
• Product Overview: Human LRP1 full-length ORF (AAH45107.1) recombinant protein without tag.

Specification

• Description: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
• Source: Wheat Germ
• Species: Human
• Form: Liquid
• Molecular Mass: 31.6 kDa
• AA Sequence: MLTPPLLLLLPLLSALVAAAIDAPK TCSPKQFACRDQITCISKGWRCDGE RDCPDGSDEAPEICPQSKAQRCQPN EHNCLGTELCVPMSRLCNGVQDCMD GSDEGPHCRELQGNCSRLGCQHHCV PTLDGPTCYCNSSFQLQADGKTCKD FDECSVYGTCSQLCTNTDGSFICGC VEGYLLQPDNRSCKAKNEPVDRPPV LLIANSQNILATYLSGAQVSTITPT STRQTTAMDFSYANETVCWVHVGDS AAQTQLKCARMPGLKGFVDEHTINI SLSLHLCVFSKSQQEMG
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Usage: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: LRP1 low density lipoprotein receptor-related protein 1 [ Homo sapiens ]
• Official Symbol: LRP1
• Synonyms: LRP1; low density lipoprotein receptor-related protein 1; A2MR, alpha 2 macroglobulin receptor , APR; prolow-density lipoprotein receptor-related protein 1; CD91; LRP; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor; APR; A2MR; APOER; TGFBR5; IGFBP3R; FLJ16451; MGC88725
• Gene ID: 4035
• mRNA Refseq: NM_002332
• Protein Refseq: NP_002323
• MIM: 107770
• UniProt ID: Q07954