Recombinant Human MAP2K4 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MAP2K4-3115H
• Product Overview: MAP2K4 MS Standard C13 and N15-labeled recombinant protein (NP_003001) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 44.1 kDa
• AA Sequence: MAAPSPSGGGGSGGGRGSGTPGPVG SPAPGHPAVSSMQGKRKALKLNFAN PPFKSTARFTLNPNPTGVQNPHIER LRTHSIESSGKLKISPEQHWDFTAE DLKDLGEIGRGAYGSVNKMVHKPSG QIMAVKRIRSTVDEKEQKQLLMDLD VVMRSSDCPYIVQFYGALFREGDCW ICMELMSTSFDKFYKYVYSVLDDVI PEEILGKITLATVKALNHLKENLKI IHRDIKPSNILLDRSGNIKLCDFGI SGQLVDSIAKTRDAGCRPYMAPERI DPSASRQGYDVRSDVWSLGITLYEL ATGRFPYPKWNSVFDQLTQVVKGDP PQLSNSEEREFSPSFINFVNLCLTK DESKRPKYKELLKHPFILMYEERAV EVACYVCKILDQMPATPSSPMYVDT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MAP2K4 mitogen-activated protein kinase kinase 4 [ Homo sapiens (human) ]
• Official Symbol: MAP2K4
• Synonyms: MAP2K4; mitogen-activated protein kinase kinase 4; SERK1; dual specificity mitogen-activated protein kinase kinase 4; JNKK1; MEK4; MKK4; PRKMK4; MEK 4; MAPKK 4; SAPK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; MAP kinase kinase 4; JNK-activated kinase 1; JNK activating kinase 1; JNK-activating kinase 1; c-Jun N-terminal kinase kinase 1; stress-activated protein kinase kinase 1; JNKK; SEK1; MAPKK4; SAPKK1; SAPKK-1
• Gene ID: 6416
• mRNA Refseq: NM_003010
• Protein Refseq: NP_003001
• MIM: 601335
• UniProt ID: P45985