Recombinant Human Matrix Metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Cat.No. : MMP2-1716H
Product Overview : Recombinant humanMPP2 expressed by CHOcellsis a 72 kDa Proenzymeprotein.
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Cat. No. : MMP2-1716H
Description : 72 kDa type IV collagenase alsoknown as matrix metalloproteinase-2 (MMP2) and gelatinase A is an enzyme thatin humans is encoded by the MMP2 gene. Proteins of the matrixmetalloproteinase (MMP) family are involved in the breakdown of extracellularmatrix in normal physiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in disease processes, such asarthritis and metastasis.
Concentration : Batch dependent - please inquireshould you have specific requirements.
Source : Human
Host : CHO cells
Form : 150mM NaCl, 20mMTris-HCl, 5mM CaCl2, with 0.05% BRIJ -35 Detergent, pH 7.4.
Purity : > 90% pure by SDS PAGE
Molecular Mass : 72 kDa
Applications : Numerous applications are possiblewith this product and should be tested by the end user under their ownlaboratory conditions.
Storage : Aliquot and storeat -70 deg C or lower. Avoid repeated freeze/thaw cycles.
OfficialSymbol : MMP2
SDS-PAGE:
Gene Name : MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDagelatinase, 72kDa type IV collagenase) [ Homo sapiens ]
Synonyms : MMP2; matrixmetallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IVcollagenase); CLG4; MONA; CLG4A; TBE-1; MMP-II; 72 kDa type IV collagenase; MMP-2; gelatinase A;72 kDa gelatinase; OTTHUMP00000164261; collagenase type IV-A; neutrophilgelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II
Gene ID : 4313
mRNA Refseq : NM_001127891
Protein Refseq : NP_001121363
MIM : 120360
UniProt ID : P08253
Chromosome Location : 16q13-q21
Pathway : ATF-2 transcription factornetwork; Angiopoietin receptor Tie2-mediated signaling; Bladder cancer;Diabetes pathways; Direct p53 effectors; FOXM1 transcription factor network;GnRH signaling pathway; IL-3 Signaling Pathway; LPA receptor mediated events;Leukocyte transendothelial migration; Matrix Metalloproteinases;Osteopontin-mediated events; Pathways in cancer; Plasma membrane estrogenreceptor signaling; Regulation of Insulin-like Growth Factor (IGF) Activityby Insulin-like Growth Factor Binding Proteins (IGFBPs); Regulation ofWnt-mediated beta catenin signaling and target gene transcription;Syndecan-2-mediated signaling events; Validated transcriptional targets ofAP1 family members Fra1 and Fra2; amb2 Integrin signaling
Function : metalion binding; metalloendopeptidase activity; peptidase activity; zinc ionbinding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to regulate the activity of MMP2 in tumor therapy? 10/20/2022

The activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.

How is MMP2 related to metastases that promote disease progression? 05/04/2022

MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.

What are the application prospects of MMP2 inhibitors? 02/20/2022

Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.

Does MMP2 interact with the tumor microenvironment? 09/15/2021

MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.

What is the role of MMP2 in embryonic development? 10/18/2020

It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.

What are the effects of MMP2 mutations in human disease? 10/13/2020

Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.

Customer Reviews (3)

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06/19/2021

    The solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.

    05/13/2021

      Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.

      03/16/2021

        MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.

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