Active Native Human MMP2 protein
Cat.No. : | MMP2-248H |
Product Overview : | Native Human MMP2 protein(NP_004521.1) (Met 1-Cys 660) was expressed and purified in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | Non |
Form : | Lyophilized from sterile 0.05 % Brij-35, 150 mM NaCl, 5 mM CaCl2, 50 mM Tris, pH 7.5.Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Bio-activity : | 1. Measured by its ability to cleave the fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2. The specific activity is > 1,000 pmoles/min/µg.(Activation description: The proenzyme needs to be activated by APMA for an activated form)2. Measured by its binding ability in a functional ELISA. Immobilized Human MMP-2 at 2 μg/ml (100 μl/well) can bind Human TIMP2 hFc, the EC50 of Human TIMP2 hFc is 6.0-30.0 ng/mL. |
Molecular Mass : | The recombinant human MMP2 consists of 631 amino acids and migrates as an 72 kDa band as predicted in SDS-PAGE under reducing conditions. |
Protein Length : | Met1-Cys660 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 90 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Products Types
◆ Recombinant Protein | ||
MMP2-1419H | Recombinant Human MMP2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP2-1121H | Recombinant Human MMP2 Protein, His-tagged | +Inquiry |
Mmp2-44M | Recombinant Mouse MMP-2/TIMP-2 Complex | +Inquiry |
MMP2-182H | Active Recombinant Human MMP2 Protein, His-tagged | +Inquiry |
MMP2-1120H | Recombinant Human MMP2 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
MMP2-47H | Native Human MMP-2/TIMP-2 Complex | +Inquiry |
MMP2-46H | Native Human MMP-2 | +Inquiry |
MMP2-8455M | Native Mouse MMP2 | +Inquiry |
◆ Lysates | ||
MMP2-2380HCL | Recombinant Human MMP2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0320C | MMP2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.
Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.
MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.
Q&As (6)
Ask a questionThe activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.
MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.
Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.
MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.
It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.
Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.
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