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Recombinant Human MGMT Protein, His-tagged

Cat.No. : MGMT-075H
Product Overview : Recombinant active N-terminal His-tagged human MGMT protein was expressed in E. coli.
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  • Gene Information
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Description : Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 26.8 kDa
Purity : ≥50% estimated by SDS-PAGE
Stability : ≥ 6 months
Storage : At -80 centigrade.
Storage Buffer : 50 mM Tris, pH 8.0, 150 mM sodium chloride, 10% glycerol
Gene Name : MGMT O-6-methylguanine-DNA methyltransferase [ Homo sapiens (human) ]
Official Symbol : MGMT
Synonyms : MGMT; O-6-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase; 6-O-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase; methylguanine-DNA methyltransferase; EC 2.1.1.63
Gene ID : 4255
mRNA Refseq : NM_002412
Protein Refseq : NP_002403
MIM : 156569
UniProt ID : B4DEE8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can MGMT status be used to predict the response to other types of cancer treatments? 01/31/2022

Yes, MGMT status has implications beyond glioblastoma and can influence the response to various alkylating agents in different cancer types.

Can the MGMT protein be targeted for cancer prevention strategies? 03/24/2020

While direct targeting is challenging, understanding MGMT's role may lead to the development of preventive strategies, such as identifying high-risk individuals for regular screenings.

Is MGMT involved in resistance mechanisms to chemotherapy? 10/08/2018

Yes, MGMT expression can confer resistance to alkylating agents, making it an important factor in understanding and overcoming chemotherapy resistance.

How does MGMT repair DNA damage caused by environmental factors like radiation? 08/21/2018

MGMT repairs DNA damage by directly removing alkyl groups from the O6-position of guanine, which can be induced by exposure to radiation and certain chemicals.

How does MGMT status affect the choice of chemotherapy in glioblastoma patients? 04/25/2018

Glioblastoma patients with MGMT promoter methylation are more likely to benefit from alkylating agents like temozolomide.

Customer Reviews (3)

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Reviews
05/31/2021

    The MGMT protein is an exceptional protein solution that exceeds expectations in terms of quality and suitability for my experimental requirements.

    12/15/2018

      In addition to its outstanding quality, the MGMT protein comes with exceptional technical support from its manufacturer.

      03/07/2017

        I am confident that utilizing the MGMT protein will empower me to uncover crucial insights into cellular mechanisms with precision.

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