Recombinant Human NFATC1

• Cat.No.: NFATC1-29253TH
• Product Overview: Recombinant full length NFAT2 protein (Human), expressed by baculovirus in Sf9 insect cells, with an N terminal enzyme tag, MW 125kDa. [

Specification

• Description: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
• Tissue specificity: Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isof
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Contains 1 RHD (Rel-like) domain.
• Tag: Non

Gene Information

• Gene Name: NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [ Homo sapiens ]
• Official Symbol: NFATC1
• Synonyms: NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; nuclear factor of activated T-cells, cytoplasmic 1; NF ATC; NFAT2; NFATc
• Gene ID: 4772
• mRNA Refseq: NM_006162
• Protein Refseq: NP_006153
• MIM: 600489
• Uniprot ID: O95644
• Chromosome Location: 18q23
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem
• Function: DNA binding; FK506 binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding