| Description : |
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
77.8 kDa |
| AA Sequence : |
MPSTSFPVPSKFPLGPAAAVFGRGE TLGPAPRAGGTMKSAEEEHYGYASS NVSPALPLPTAHSTLPAPCHNLQTS TPGIIPPADHPSGYGAALDGGPAGY FLSSGHTRPDGAPALESPRIEITSC LGLYHNNNQFFHDVEVEDVLPSSKR SPSTATLSLPSLEAYRDPSCLSPAS SLSSRSCNSEASSYESNYSYPYASP QTSPWQSPCVSPKTTDPEEGFPRGL GACTLLGSPRHSPSTSPRASVTEES WLGARSSRPASPCNKRKYSLNGRQP PYSPHHSPTPSPHGSPRVSVTDDSW LGNTTQYTSSAIVAAINALTTDSSL DLGDGVPVKSRKTTLEQPPSVALKV EPVGEDLGSPPPPADFAPEDYSSFQ HIRKGGFCDQYLAVPQHPYQWAKPK PLSPTSYMSPTLPALDWQLPSHSGP YELRIEVQPKSHHRAHYETEGSRGA VKASAGGHPIVQLHGYLENEPLMLQ LFIGTADDRLLRPHAFYQVHRITGK TVSTTSHEAILSNTKVLEIPLLPEN SMRAVIDCAGILKLRNSDIELRKGE TDIGRKNTRVRLVFRVHVPQPSGRT LSLQVASNPIECSQRSAQELPLVEK QSTDSYPVVGGKKMVLSGHNFLQDS KVIFVEKAPDGHHVWEMEAKTDRDL CKPNSLVVEIPPFRNQRITSPVHVS FYVCNGKRKRSQYQRFTYLPANGNA IFLTVSREHERVGCFFSGPTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
