| Species : |
Human |
| Tag : |
Non |
| Protein Length : |
32-428 a.a. |
| Description : |
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. |
| Tissue specificity : |
Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain. |
| Form : |
Lyophilised:Reconstitution: It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze tha |
| Purity : |
>95% by SDS-PAGE |
| Storage buffer : |
Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin, PBS |
| Storage : |
Store at +4°C. |
| Sequences of amino acids : |
Theoretical Sequence:CPANCVCSKTEINCRRPDDGNLFPLLEGQ DSGNSNGNANINITDISRNITSIHIENWRSLHTLNAVD MELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNR LTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQE QGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSH VNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTH QTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGM SNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPT LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTH YNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDGSSNTKVDKKVEPKSCDKTH TCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCV VVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRV VSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQ QGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Sequence Similarities : |
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 2 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 protein kinase domain. |
