Active Recombinant Human NTRK3 Homodimer Protein, His tagged

• Cat.No.: NTRK3-63H
• Product Overview: TrkC protein dimer contains the TrkC extracellular domain (UniProt# Q16288) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: His
• Protein Length: 32-429 aa
• Description: Human tropomyosin receptor kinase C (TrkC) is part of the family of receptor tyrosine kinases and primarily the receptor for neurotrophin-3 (NT-3). TrkC is also known as neurotrophic receptor tyrosine kinase 3 (NTRK3), NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, gp145, and GP145-TrkC. TrkC is a Type I transmembrane protein. It contains an extracellular domain with two cysteine-rich clusters (C1 and C2), three leucine-rich 24-residue repeats (LRR1–3), and two immunoglobulin-like domains (Ig1 and Ig2) followed by a transmembrane domain and a cytoplasmic domain. TrkC is a high affinity receptor for NT-3, and ligand binding induces receptor dimerization which is required for trans-autophosphorylation that triggers downstream signaling cascades. TrkC plays a role in many cancers, therefore, a recombinant protein mimicking the dimer conformation can be crucial for cancer therapeutic discovery.
• Molecular Mass: 106 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for TrkC-specific antibody and neurotrophin-3 (NT-3) ligand protein binding assays Suggested Applications: SPR & BLI for TrkC-specific antibody and NT-3 protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: NTRK3 neurotrophic tyrosine kinase, receptor, type 3 [ Homo sapiens (human) ]
• Official Symbol: NTRK3
• Synonyms: NTRK3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; TRKC; GP145-TrkC; ETV6-NTRK3 fusion; tyrosine kinase receptor C; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; gp145(trkC)
• Gene ID: 4916
• mRNA Refseq: NM_001007156
• Protein Refseq: NP_001007157
• MIM: 191316
• UniProt ID: Q16288