- Human(7)
- Rhesus Macaque(1)
Recombinant Human PDE2A Protein, His-tagged
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Cat.No. : | PDE2A-07H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant human PDE2A protein (215-900) with a C-terminal His-tag was expressed in insect cells. |
Description : | Phosphodiesterase 2A (PDE2A) is a cGMP-stimulated cyclic nucleotide phosphodiesterase that hydrolyzes cGMP and cAMP. It is a 941-amino acid protein comprised of an N-terminal domain (1-214), GAF-A domain (215-372), GAF-B domain (393-541), and a catalytic domain (579-941) and functions as a homodimer. PDE2A is expressed in the brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney, spleen, and pituitary. Upon cGMP binding to the GAF-B domain, PDE2A is activated and hydrolyzes cAMP and cGMP to regulate cell signaling. PDE2A mRNA levels are reduced in postmortem amygdala from patients with schizophrenia, bipolar disorder, and major depressive disorder compared with healthy controls. PDE2A brain activity is increased in the Fmr1-/- mouse model of fragile X syndrome and administration of the selective PDE2A inhibitor BAY 60-7550 restores axonal length and spine maturation and attenuates social discriminatory and vocalization deficits in Fmr1-/- young mice. Adenovirus shRNA knockdown of Pde2aattenuates bronchoalveolar lavage fluid (BALF) neutrophilia, reduces lung levels of inducible nitric oxide synthase (iNOS), and increases lung cAMP levels in a mouse model of acute lung injury. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile 20mM Tris, pH 7.4, with 500 mM sodium chloride and 10% glycol |
Molecular Mass : | 80 kDa |
Protein length : | 215-900 |
Endotoxin : | <1.0 EU/μg, determined by the LAL endotoxin assay |
Purity : | ≥90% estimated by SDS-PAGE |
Stability : | ≥ 1 year |
Storage : | Store at -80 centigrade |
SDS-PAGE Analysis of PDE2A : |
![]() Lane 1: MW Markers, Lane 2: PDE2A(human, recombinant; aa215-900) |
Gene Name : | PDE2A phosphodiesterase 2A [ Homo sapiens (human) ] |
Official Symbol : | PDE2A |
Synonyms : | PDE2A; phosphodiesterase 2A; PDE2A1; PED2A4; cGSPDE; CGS-PDE; cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase; phosphodiesterase 2A, cGMP-stimulated |
Gene ID : | 5138 |
mRNA Refseq : | NM_001143839 |
Protein Refseq : | NP_001137311 |
MIM : | 602658 |
UniProt ID : | Q8IW54 |
◆ Recombinant Protein
PDE4B-146H | Recombinant Human PDE2A Protein, His-tagged | +Inquiry |
PDE2A-472H | Recombinant Human PDE2A, GST-tagged, Active | +Inquiry |
PDE2A-3347R | Recombinant Rhesus monkey PDE2A Protein, His-tagged | +Inquiry |
PDE2A-606H | Recombinant Human PDE2A | +Inquiry |
PDE2A -906H | Recombinant Human PDE2A , His tagged | +Inquiry |
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◆ Lysates
PDE2A-591HCL | Recombinant Human PDE2A cell lysate | +Inquiry |
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◆ Assay kits
Kit-1833 | PDE2A Assay Kit II | +Inquiry |
Kit-1832 | PDE2A Assay Kit I | +Inquiry |
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Pde10aPDE11APDE1APDE1BPde1cPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6BPDE6CPDE6DPDE7APDE7BPDE8APDE9APDE4DIPPDE12PDE6APDE8BPDE6GPDE6H
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