Recombinant Human PDXP Protein (1-296 aa), His-tagged

• Cat.No.: PDXP-2078H
• Product Overview: Recombinant Human PDXP Protein (1-296 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Full Length.

Specification

• Description: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 33.7 kDa
• Protein length: 1-296 aa
• AA Sequence: MARCERLRGAALRDVLGRAQGVLFD CDGVLWNGERAVPGAPELLERLARA GKAALFVSNNSRRARPELALRFARL GFGGLRAEQLFSSALCAARLLRQRL PGPPDAPGAVFVLGGEGLRAELRAA GLRLAGDPSAGDGAAPRVRAVLVGY DEHFSFAKLREACAHLRDPECLLVA TDRDPWHPLSDGSRTPGTGSLAAAV ETASGRQALVVGKPSPYMFECITEN FSIDPARTLMVGDRLETDILFGHRC GMTTVLTLTGVSRLEEAQAYLAAGQ HDLVPHYYVESIADLTEGLED
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase [ Homo sapiens ]
• Official Symbol: PDXP
• Synonyms: PDXP; dJ37E16.5; FLJ32703; chronophin; PLP phosphatase; CIN; PLP
• Gene ID: 57026
• mRNA Refseq: NM_020315
• Protein Refseq: NP_064711
• MIM: 609246
• UniProt ID: Q96GD0