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Recombinant Human PIK3CA/PIK3R1, His-tagged, Active

Cat.No. : PIK3CA/PIK3R1-389H
Product Overview : Recombinant human full-length p110α (E545K) mutant subunit and human p85α wild-type subunit were co-expressed by baculovirus inSf9 insect cellsusing an N-terminal His tag on both proteins. MW=111 kDa (p110α), ~86 kDa (p85α).
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  • Gene Information
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Cat. No. : PIK3CA/PIK3R1-389H
Description : The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110α catalytic subunit (PIK3CA) is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of p110α is essential for vascular development and inactivation of p110α leads to severe defects in angiogenic sprouting and vascular remodeling.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide [ Homo sapiens ],PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [ Homo sapiens ]
Synonyms : PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3K; MGC142161; MGC142163; p110-alpha; Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; EC; PI3-kinase p110 subunit alpha; PtdIns-3-kinase p110; PI3Kbeta; PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); p85; GRB1; p85-ALPHA
Gene ID : 5290,5295
mRNA Refseq : NM_006218,NM_181504
Protein Refseq : NP_006209,NP_852556
UniProt ID : P42336, P27986
Chromosome Location : 3q26.3, 5q13.1
MIM : 171834,171833
Pathway : Calcium signaling pathway; Insulin signaling pathway; Metabolism of carbohydrates; Chronic myeloid leukemia; Pancreatic cancer; Pathways in cancer; Small cell lung cancer; T cell receptor signaling pathway; Acute myeloid leukemia; Colorectal cancer; Endometrial cancer; Fc gamma R-mediated phagocytosis; Fc epsilon RI signaling pathway; Acute myeloid leukemia; Jak-STAT signaling pathway; Leukocyte transendothelial migration; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Phosphatidylinositol signaling; Progesterone-mediated oocyte maturation; Prostate cancer; Regulation of actin cytoskeleton; Renal cell carcinoma; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Type II diabetes mellitus; VEGF signaling pathway; mTOR signaling pathway
Function : ATP binding; nucleotide binding; transferase activity; 1-phosphatidylinositol-3-kinase activity; inositol or phosphatidylinositol kinase activity; insulin receptor substrate binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotransferase activity, alcohol group as acceptor; ErbB-3 class receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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