| Description : |
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| Source : |
HEK293 |
| Species : |
Human |
| Form : |
Lyophilized |
| Molecular Mass : |
45 kDa |
| Protein Length : |
431 |
| AA Sequence : |
MRALLARLLLCVLVVSDSKGSNELH QVPSNCDCLNGGTCVSNKYFSNIHW CNCPKKFGGQHCEIDKSKTCYEGNG HFYRGKASTDTMGRPCLPWNSATVL QQTYHAHRSDALQLGLGKHNYCRNP DNRRRPWCYVQVGLKPLVQECMVHD CADGKKPSSPPEELKFQCGQKTLRP RFKIIGGEFTTIENQPWFAAIYRRH RGGSVTYVCGGSLISPCWVISATHC FIDYPKKEDYIVYLGRSRLNSNTQG EMKFEVENLILHKDYSADTLAHHND IALLKIRSKEGRCAQPSRTIQTICL PSMYNDPQFGTSCEITGFGKENSTD YLYPEQLKMTVVKLISHRECQQPHY YGSEVTTKMLCAADPQWKTDSCQGD SGGPLVCSLQGRMTLTGIVSWGRGC ALKDKPGVYTRVSHFLPWIRSHTKE ENGLAL |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
