Recombinant Human Sialophorin

• Cat.No.: SPN-4264H
• Product Overview: CD43 Human Recombinant (aa 271-401) expressed in E.coli, shows a 41 kDa band on SDS-PAGE. The CD43 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: SPN-4264H
• Description: CD43 (Sialophorin, Leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.
• Source: Human
• Host: Escherichia Coli.
• Form: CD43 at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Physical Appearance: Sterile Filtered clear solution.
• Storage: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
• Tag: Non
• Protein length: 271-401

Gene Information

• Gene Name: SPN sialophorin [ Homo sapiens ]
• Official Symbol: SPN
• Synonyms: Leukosialin; GALGP; OTTHUMP00000123397; GPL115; OTTHUMP00000196610; sialophorin (leukosialin, CD43); sialophorin (gpL115, leukosialin, CD43); CD43 antigen; Leukocyte sialoglycoprotein; Galactoglycoprotein; LSN; CD43; SPN; sialophorin; Sialophorin
• Gene ID: 6693
• mRNA Refseq: NM_001030288
• Protein Refseq: NP_001025459
• MIM: 182160
• UniProt ID: P16150
• Chromosome Location: 16p11.2
• Pathway: Basigin interactions; Cell adhesion molecules (CAMs); Cell adhesion molecules (CAMs); Cell surface interactions at the vascular wall; Hemostasis, organism-specific biosystem
• Function: bacterial cell surface binding; binding; transmembrane receptor activity

Reviews

06/23/2023

Accurate and timely results, crucial for research progress.

10/02/2018

Instrumental in our research achievements, highly trusted.

03/26/2018

Efficient and dependable, aids our research significantly.

Q&As

What is the primary role of SPN in immune cell function?

SPN, or Sialophorin, is important in modulating the function of immune cells, particularly lymphocytes.

What potential therapeutic applications arise from targeting SPN in immune disorders?

Targeting SPN could provide new treatment approaches for managing immune-related conditions, including autoimmune diseases.

How do genetic variations in SPN affect immune response?

Genetic changes in SPN can lead to variations in immune cell behavior and effectiveness.

What role does SPN play in cell adhesion and migration?

SPN plays a role in regulating immune cell adhesion and migration, crucial for immune surveillance and response.

How does SPN interact with other components of the immune system?

SPN interacts with other immune molecules, coordinating immune cell communication and function.

What is the impact of altered SPN activity on autoimmune diseases?

Altered SPN activity can impact the regulation of immune responses, potentially leading to autoimmune disorders.

How does SPN contribute to immune cell signaling?

It contributes to immune cell signaling, influencing cell activation and response to stimuli.