Recombinant Human SPN Protein, MYC/DDK-tagged

Cat.No. : SPN-2685H
Product Overview : Recombinant Human SPN protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
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Description : The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 40.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : SPN sialophorin [ Homo sapiens ]
Official Symbol : SPN
Synonyms : CD43; GALGP; GPL115; LSN
Gene ID : 6693
mRNA Refseq : NM_001030288
Protein Refseq : NP_001025459
MIM : 182160
UniProt ID : P16150

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary role of SPN in immune cell function? 12/29/2022

SPN, or Sialophorin, is important in modulating the function of immune cells, particularly lymphocytes.

What potential therapeutic applications arise from targeting SPN in immune disorders? 12/28/2022

Targeting SPN could provide new treatment approaches for managing immune-related conditions, including autoimmune diseases.

How do genetic variations in SPN affect immune response? 07/10/2019

Genetic changes in SPN can lead to variations in immune cell behavior and effectiveness.

What role does SPN play in cell adhesion and migration? 12/12/2018

SPN plays a role in regulating immune cell adhesion and migration, crucial for immune surveillance and response.

How does SPN interact with other components of the immune system? 05/13/2018

SPN interacts with other immune molecules, coordinating immune cell communication and function.

What is the impact of altered SPN activity on autoimmune diseases? 02/12/2018

Altered SPN activity can impact the regulation of immune responses, potentially leading to autoimmune disorders.

How does SPN contribute to immune cell signaling? 08/11/2017

It contributes to immune cell signaling, influencing cell activation and response to stimuli.

Customer Reviews (3)

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06/23/2023

    Accurate and timely results, crucial for research progress.

    10/02/2018

      Instrumental in our research achievements, highly trusted.

      03/26/2018

        Efficient and dependable, aids our research significantly.

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