Recombinant Human STAT3
Cat.No. : | STAT3-2172H |
Product Overview : | Recombinant Human STAT3 protein was expressed in an E. coli strain that carries the full-length coding sequence for human STAT3 under the control of a T7 promoter. |
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Description : | STAT3 (signal transducer and activator of transcription 3) is a member of the STAT family of transcription factors. STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. The STAT3 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFNα, IL-10, IL-6, IL-11, IL-12, IL-2, EGF, among others. |
Source : | E. coli |
Species : | Human |
Form : | The protein diluted in 20 mM Tris-Cl (pH 8), 20% glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA. |
Applications : | Recombinant STAT3 protein can be used for in vitro transcription, gel mobility shift assays, Western blot (80 kDa) and for protein-protein interactions assays. |
Usage : | This product is for research use only and is not for use in diagnostic procedures. |
Stability : | This product is guaranteed for 6 months from date of receipt. |
Tag : | Non |
Gene Name : | STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Homo sapiens ] |
Official Symbol : | STAT3 |
Synonyms : | APRF; HIES; ADMIO; signal transducer and activator of transcription 3; DNA-binding protein APRF; acute-phase response factor |
Gene ID : | 6774 |
mRNA Refseq : | NM_213662 |
Protein Refseq : | NP_998827 |
MIM : | 102582 |
UniProt ID : | P40763 |
Chromosome Location : | 17q21.31 |
Pathway : | AGE/RAGE pathway, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Cellular responses to stress, organism-specific biosystem |
Function : | CCR5 chemokine receptor binding; DNA binding; protein binding |
Products Types
◆ Recombinant Protein | ||
STAT3-8786M | Recombinant Mouse STAT3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Stat3-6170M | Recombinant Mouse Stat3 Protein, Myc/DDK-tagged | +Inquiry |
STAT3-001H | Recombinant Human STAT3 Protein, His-tagged | +Inquiry |
Stat3-2107R | Recombinant Rat Stat3 Protein, His-tagged | +Inquiry |
STAT3-4148H | Recombinant Human STAT3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
STAT3-1418HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
STAT3-1417HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewProtein worked well in assay.
Fast shipping, great customer service.
Excellent purity, highly recommend.
Q&As (7)
Ask a questionYes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.
Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.
STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.
Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.
STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.
The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.
STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.
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