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| Official Full Name | Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor) |
| Background | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. |
| Synonyms | STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
STAT3 involved in several pathways and played different roles in them. We selected most pathways STAT3 participated on our site, such as Chemokine signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | GM1987; CCR1L1; PTK2; CXCR3; CCL2; GM13306; CCL15; CCR7; BRAF; CXCL9 |
| HIF- signaling pathway | PIK3R5; EPO; EP300; PFKL; ALDOA; HK2; ANGPT4; HMOX1; IGF1R; HK1 |
| FoxO signaling pathway | HRASA; MAPK14A; PIK3R5; CCNB3; SMAD2; TGFB3; SGK3; NLK; FBXO32; TGFB1A |
| Signaling pathways regulating pluripotency of stem cells | RAF1; MAPK3; MAPK12; INHBB; FZD1; Fzd4; WNT3A; IGF1; POU5F1; PCGF5 |
| Jak-STAT signaling pathway | IFNA14; Il2; JAK2B; RAF1B; SOCS7; PIAS4A; IL4R; IL22; IFNA13; FHL1 |
| Prolactin signaling pathway | MAPK10; IRF1; MAPK12; AKT2; MAPK8; PRL; AKT1; RELA; CSH; FOXO3 |
| Adipocytokine signaling pathway | ADIPOR1B; G6PCA.2; IRS2; JAK2; LEPB; CPT1A; PPARGC1A; ACSBG2; CPT1B; AKT2 |
| Insulin resistance | MAPK8A; PRKCBA; PPARGC1A; NFKBIAA; PCK2; GYS1; PRKCB; PTPRF; PRKAG2A; G6PC3 |
| Toxoplasmosis | TNF; TRAF6; Toxoplasma Gondii Microneme Protein MIC3; HSPA1B; LAMA2; NFKBIA; PIK3CB; BCL2L1; PIK3CD; MAPK3 |
| Hepatitis C | IRF7; IFNAR2; OAS1; TBK1; PPP2R2A; CLDN6; OAS2; RNASEL; PIK3R1; RELA |
| Hepatitis B | TGFB1; CREB3L3; FAS; TGFBR1; HRAS; MAPK10; IKBKG; NFKBIA; CCNE1; MYD88 |
| Measles | TP73; CCND1; IFNA4; EIF3H; PIK3CD; TRAF6; CCNE2; MSN; HSPA2; STAT5B |
| Epstein-Barr virus infection | PSMD2; POLR3G; MAPK11; HSPA1B; POLR2G; POLR3F; HSPA2; RELA; FGR; MAP2K3 |
| Pathways in cancer | AXIN2; FZD2; GNAQ; FGFR2; PTGER4; MSH6; GNAS; TP53; CBL; WNT8B |
| Viral carcinogenesis | TRAF1; PIK3R1; CCNA2; DLG1; ACTN4; NFKB1; VAC14; YWHAG; H2BFWT; PIK3R2 |
| Proteoglycans in cancer | SOS1; HPSE; CAV3; MAPK1; DDX5; ANK2; MAP2K1; MAP2K2; PRKACG; LUM |
| MicroRNAs in cancer | SPRY2; SERPINB5; MDM4; CDC25C; TTC6; HRAS; Pdgfa&Pdgfb; CCNG1; MARCKS; ZEB1 |
| Pancreatic cancer | TGFB3; PIK3CB; TRP53; MAPK8; MAPK1; NFKB1; VEGFA; IKBKG; MAPK10; RB1 |
| Acute myeloid leukemia | RELA; MAP2K1; SFPI1; SPI1; STAT3; PIK3CB; PIM1; ZBTB16; PIK3CD; PPARD |
| Inflammatory bowel disease (IBD) | IL5; IL12A; H2-AA; IL4; HLA-DRB4; TNF; IFNGR2; IFNG; STAT6; HLA-DOA |
STAT3 has several biochemical functions, for example, CCR5 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT3 itself. We selected most functions STAT3 had, and list some proteins which have the same functions with STAT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR5 chemokine receptor binding | JAK1; CCL3; CCL4; CCL5; STAT3; CNIH4 |
| DNA binding | ZBTB1; ZNF563; H1FNT; PRRX1B; NKX2.5; IRF2; NKX6.3; ZFP507; PIAS1; ZFP827 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | BCL11B; DLX5; MEOX2; RBPJB; MAFA; ELK3; FOSL1; NKX2-5; SPI1; JUNB |
| RNA polymerase II repressing transcription factor binding | GSC; BBS4; MTA2; TCERG1; TBX5A; TCF7L2; MIXL1; TTC8; SP1; RBBP8 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR5A1; NR2F6; NR6A1; RORC; NR4A2A; RORA; PPARA; ESRRA; NR2F1B; HNF4A |
| glucocorticoid receptor binding | EP300; ETS2; YWHAH; NRIP1; CEBPB; STAT3; NR4A2; STAT5B; FKBP4; GRIP1 |
| protein binding | UPF3B; CCDC12; KRR1; NEK2; SOCS1; PPP3CC; PSENEN; FGFRL1B; LILRB4; DHX40 |
| protein dimerization activity | OLIG3; KIF9; MEF2D; AHR; ASCL1B; HES2; ARNTL2; ARNTL; MYC; NCOA1 |
| protein kinase binding | CDK5RAP2; NCS1; FOXO3; CAMK2N2; PRDX3; TRP53; AP2A2; FER; TEX14; NBEA |
| protein phosphatase binding | ROS1; NEK2; ITGA1; RPA3; KAT2A; ERBB2; ITPR1; ANAPC5; TRAF3; MAP2K7 |
| signal transducer activity | VMN1R46; CD40; C18orf32; TAAR11; GNA12; VAPA; MAVS; CANT1; TNK1; GNA13 |
| transcription factor activity, sequence-specific DNA binding | RORAA; FOXI3A; FLI1; RORB; TCF3; SP140; TCEAL1; RARG; TRIM22; ZNF189 |
| transcription factor binding | HDAC9; EGR1; HYAL1; GNPTAB; DRAP1; SNF8; HDAC8; JUNBA; EPN1; E2F5 |
| transcription regulatory region DNA binding | FOXC1; ATF3; TBL1X; XRCC6; RCOR1; HIVEP2; GABPB1; FOXC2; HDAC1; H2AFY |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PLAG1; NOBOX; SOX12; BCL11B; NPAS4; ISL1; HEYL; PBX1; EBF1; FOXI1 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | FOXF1; BARHL1B; CREB3L3; FOXO3; ATF3; NHLH1; ONECUT3; GATA2; PPARG; LMO2 |
STAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT3.
EGFR; ERBB2
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