STAT3

  • Official Full Name

    Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)

  • Overview

    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.
  • Synonyms

    STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Human, Mouse, Rat, Bos taurus; Cattle
  • Mouse
  • Rat
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect cells
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • DYKDDDDK
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|MBP
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STAT3-1496H Recombinant Human STAT3, GST-tagged Sf9 Insect Cell GST
Human STAT3-29823TH Recombinant Human STAT3, His-tagged E.coli His
Human STAT3-281H Recombinant Human STAT3, GST-tagged Wheat Germ GST
Human STAT3-335H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP 9-265 aa
Human STAT3-29822TH Recombinant Human STAT3, His-tagged His
Human STAT3-2176H Recombinant Human STAT3, His-tagged E.coli His
Human STAT3-282H Recombinant Human STAT3, GST-tagged Wheat Germ GST
Human STAT3-73H Recombinant Human Signal Transducer And Activator Of Transcription 3 E.coli N/A
Human STAT3-2174H Recombinant Human STAT3, MYC/DDK-tagged HEK293 Myc/DDK
Human STAT3-31H Recombinant Human STAT3 protein, His-tagged E.coli His
Human STAT3-39228H Recombinant Human STAT3, GST-tagged E.coli GST False
Human STAT3-2175H Recombinant Human STAT3, MYC/DDK-tagged HEK293 Myc/DDK
Human STAT3-30H Recombinant Human STAT3 protein, His-tagged E.coli His
Human STAT3-336H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP 272-428 aa
Human STAT3-337H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP 483-770 aa
Human STAT3-131H Recombinant Human STAT3 Mammalian Cell His
Human STAT3-316H Recombinant Human STAT3 protein, His-tagged Yeast His
Human STAT3-2172H Recombinant Human STAT3 E.coli N/A
Human STAT3-1417HCL Recombinant Human STAT3 293 Cell Lysate HEK293 N/A
Human STAT3-1418HCL Recombinant Human STAT3 293 Cell Lysate HEK293 N/A
Human STAT3-6362H Recombinant Human STAT3 Protein (Met1-Met770), N-GST tagged E.coli N-GST Met1-Met770
Human STAT3-951H Recombinant Human STAT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human STAT3-151H Recombinant Human STAT3 Protein, His-tagged Human cells His
Human STAT3-4148H Recombinant Human STAT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human STAT3-138H Recombinant Human STAT3 Protein, His-tagged Insect Cell His
Human STAT3-153H Recombinant Human STAT3 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human STAT3-001H Recombinant Human STAT3 Protein, His-tagged Insect cells His
Human STAT3-4148H-B Recombinant Human STAT3 Protein Pre-coupled Magnetic Beads HEK293
Human STAT3-5975H Recombinant Human STAT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human STAT3-152H Recombinant Human STAT3 Protein, His-tagged Human Cells His
Human STAT3-0679H Active Recombinant Human STAT3 protein, His-tagged E.coli His Gly127-Arg688
Human STAT3-4574HFL Recombinant Full Length Human STAT3, Flag-tagged Mamanlian cells Flag
Human STAT3-07H Recombinant Human STAT3 Protein, His-tagged Insect Cell His
Human STAT3-1107H Recombinant Human STAT3 protein, His-tagged E.coli His 1-770aa
Human STAT3-3533H Recombinant Human STAT3 protein, His-SUMO-tagged E.coli His-SUMO 50-240aa
Human STAT3-507HF Recombinant Full Length Human STAT3 Protein, GST-tagged In Vitro Cell Free System GST 769 amino acids
Human STAT3-184M Recombinant Human STAT3 protein, His-tagged E.coli His 600aa
Human STAT3-0258H Recombinant Human STAT3 Protein (Full Length), C-His-tagged Baculovirus-Insect cells C-His Full Length
Mouse STAT3-16109M Recombinant Mouse STAT3 Protein Mammalian Cell His
Mouse Stat3-8593M Recombinant Mouse Stat3 protein, His-tagged E.coli His Thr346~Glu552
Mouse STAT3-8786M-B Recombinant Mouse STAT3 Protein Pre-coupled Magnetic Beads HEK293
Mouse STAT3-8786M Recombinant Mouse STAT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Stat3-6170M Recombinant Mouse Stat3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat STAT3-5778R Recombinant Rat STAT3 Protein Mammalian Cell His
Rat STAT3-5437R Recombinant Rat STAT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat STAT3-5437R-B Recombinant Rat STAT3 Protein Pre-coupled Magnetic Beads HEK293
Rat Stat3-2107R Recombinant Rat Stat3 Protein, His-tagged E.coli N-His Gly656-Ser768
Cattle STAT3-1735C Recombinant Cattle STAT3 protein, His-tagged E.coli His Val563~Leu670 (Accession # Q32LP6)
Human, Mouse, Rat, Bos taurus; Cattle STAT3-2837H Recombinant Human STAT3 Protein, His-tagged E.coli N-His Ala135-Gln279
Zebrafish STAT3-9038Z Recombinant Zebrafish STAT3 Mammalian Cell His
Chicken STAT3-2620C Recombinant Chicken STAT3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • STAT3 Related Articles
  • STAT3 Related Gene Family
  • STAT3 Related Research Area
  • STAT3 Related Signal Pathway

STAT3 involved in several pathways and played different roles in them. We selected most pathways STAT3 participated on our site, such as Chemokine signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayCcl9;PRKCZ;IL-8;CCR10;PAK1;CRK;VAV1;GNG13;Ccl12
HIF- signaling pathwayRPS6KB1;IGF1;INS;CAMK2A;TF;IFNGR1;VEGFA;RBX1;ARNT
FoxO signaling pathwayBCL6;IRS2;BNIP3;PRKAB1;CCNB2;MAPK13;SLC2A4;FBXO32;ARAF
Signaling pathways regulating pluripotency of stem cellsZFHX3;SKIL;NANOG;WNT5B;ID3;PCGF2;NEUROG1;ESX1;REST
Jak-STAT signaling pathwayIFNA4;IL6ST;IL22RA1;IFNG1-2;CCND2;PIK3R3;M17;Gh;Il6ra
Prolactin signaling pathwaySOCS6;MAPK13;INS;FOS;SOCS5;GRB2;STAT1;SOCS3;CCND1
Adipocytokine signaling pathwayTNFRSF1B;CAMKK1;SOCS3;PRKAB1;RXRB;NFKBIA;RXRGB;MAPK8;IRS2
Insulin resistanceRPS6KAL;IRS2;PYGM;PRKAG3B;G6PC3;GFPT2;PRKAG2;MAPK8;PRKCBB
ToxoplasmosisGNAI1;CASP8;TLR2;HLA-DQA1;HLA-DMB;GNAI2;HLA-DRA;MAPK10;IL12B
Hepatitis CNFKBIA;CLDN5;PPP2R1A;IFNA7;CLDN22;IFN-a;EIF2AK4;BAD;IL-8
Hepatitis BKRAS;PTEN;CCNA1;PIK3CB;IKBKE;YWHAB;CCNA2;STAT3;Fasl
MeaslesDOK1;PIK3CB;TACR1;IFNG;EIF3H;PIK3R5;IFNA16;TNFSF10;TLR4
Epstein-Barr virus infectionPOLR2A;PSMD6;PSMD13;TRAF3;AKT1;GTF2E1;PSMC1;RAN;PRKACG
Pathways in cancerLAMC2;RB1;FZD2;GNG12;NKX3;WNT5A;MMP1;KITLG;CCNE1
Viral carcinogenesisUBR4;MAPK3;HIST1H2BA;BAD;RBL1;HIST1H4C;PIK3R5;GTF2A2;SKP2
Proteoglycans in cancerSMAD2;FLNA;MMP2;PIK3CG;CAMK2D;NUDT16L1;BRAF;PRKCB;PLCE1
MicroRNAs in cancerMAP2K2;GLS2;ABCB1;CYP24A1;CDCA5;PRKCG;TP53;SLC7A1;VEGFA
Pancreatic cancerIKBKG;PIK3CA;PLD1;RB1;ERBB2;PIK3CB;KRAS;RAD51;ARHGEF6
Acute myeloid leukemiaMTOR;CHUK;AKT2;CCND1;STAT5B;PIK3R2;NRAS;RARA;PIK3CA
Inflammatory bowel disease (IBD)IL17F;TLR5;IL23;IL4R;HLA-DRB4;HLA-DMB;TLR2;RORC;RORA

STAT3 has several biochemical functions, for example, CCR5 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT3 itself. We selected most functions STAT3 had, and list some proteins which have the same functions with STAT3. You can find most of the proteins on our site.

Function Related Protein
CCR5 chemokine receptor bindingCCL3;CNIH4;CCL5;STAT3;JAK1;CCL4
DNA bindingOLIG2;CREBZF;PPARAA;ZNF485;HIST2H3C;RC3H2;DDX41;SYCP3;PAX6A
RNA polymerase II core promoter proximal region sequence-specific DNA bindingZNF502;TP73;MYBL2;PRDM5;HIST2H3A;RUNX2;ZNF695;ATF3;OTX1
RNA polymerase II repressing transcription factor bindingGSC;BBS7;TCF7L2;MTA2;HDAC2;PPARA;RBBP8;RBPJ;TBX5A
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingNR6A1;NR1I2;PTGER3;NR5A1B;NR2E3;PPARAA;RORCB;NR5A1A;NR4A2A
glucocorticoid receptor bindingEP300;STAT3;STAT5B;YWHAH;FKBP4;GRIP1;NR4A2;ETS2;CEBPB
protein bindingMICALL2;APOBEC3C;TNFRSF11A;PITPNM3;HOXB6;RRS1;CALML3;SMC4;ORM1
protein dimerization activityAHRRB;BETA3;STAT3;ANO7;SREBF2;HPSE;POLR2C;HER7;ATOH1
protein kinase bindingPKD1;FBXO7;HDAC7;IFNAR2;ACTA2;GYS1;Fert2;SNAP91;RACGAP1
protein phosphatase bindingCDC27;JUPA;PPP6R3;HSF4;KCNN4;VCP;Itga10&Itgb1;AP3B1;MAP2K7
signal transducer activityOPN1LW2;CELSR1;GNAZ;YARS;TAAR7B;OLFR508;STAT3;GNA15;APLNRB
transcription factor activity, sequence-specific DNA bindingFOXC1B;SIN3A;ATF1;RORB;ATF5;HOXC5;RERE;NR2F1B;SP1
transcription factor bindingTFAP2A;Ar;PBX1;NLK;NR0B1;NFKBIA;E2F4;PIAS2;SOST
transcription regulatory region DNA bindingNCOR1;POU5F1;FOXH1;ATF4;TAF9;MZF1;XRCC6;GFI1;SIX1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingEHF;CEBPB;SOX11;GCM1;BCL11B;FOS;EBF4;CARF;ETV6
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingMAFGB;MYF6;ALX4;PPARG;MAFK;ELF5;BARX1;PKNOX1;MAF

STAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT3.

EGFR; ERBB2

Ye, F; Tang, CL; et al. MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. INTERNATIONAL JOURNAL OF CANCER 136:2120-2131(2015).
Lu, K; Fang, XS; et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. CANCER LETTERS 359:250-258(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there any known inhibitors targeting STAT3 for therapeutic purposes? 02/01/2022

Yes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.

Can STAT3 activation influence cell proliferation and survival? 11/16/2021

Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.

How does STAT3 contribute to oncogenesis and tumor progression? 04/12/2021

STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.

How can the activation of STAT3 be detected in cells? 02/24/2021

Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.

How does STAT3 interact with other signaling pathways in the cell? 08/25/2020

STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.

What are the primary upstream activators of STAT3? 01/02/2019

The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.

What role does STAT3 play in immune cell differentiation and function? 04/16/2018

STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.

Customer Reviews (3)

Write a review
Reviews
11/17/2022

    Protein worked well in assay.

    04/21/2021

      Fast shipping, great customer service.

      02/06/2018

        Excellent purity, highly recommend.

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