stat3

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stat3

Official Full Name Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)
Background The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.
Synonyms STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • DYKDDDDK
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STAT3-151H Recombinant Human STAT3 Protein, His-tagged Human cells His
    Human STAT3-152H Recombinant Human STAT3 Protein, His-tagged Human Cells His
    Human STAT3-153H Recombinant Human STAT3 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human STAT3-001H Recombinant Human STAT3 Protein, His-tagged Insect cells His
    Human STAT3-131H Recombinant Human STAT3 Mammalian Cell His
    Human STAT3-138H Recombinant Human STAT3 Protein, His-tagged Insect Cell His
    Human STAT3-1417HCL Recombinant Human STAT3 293 Cell Lysate HEK293 N/A
    Human STAT3-1418HCL Recombinant Human STAT3 293 Cell Lysate HEK293 N/A
    Human STAT3-1496H Recombinant Human STAT3, GST-tagged Sf9 Insect Cell GST
    Human STAT3-2172H Recombinant Human STAT3 E.coli N/A
    Human STAT3-2174H Recombinant Human STAT3, MYC/DDK-tagged HEK293 Myc/DDK
    Human STAT3-2175H Recombinant Human STAT3, MYC/DDK-tagged HEK293 Myc/DDK
    Human STAT3-2176H Recombinant Human STAT3, His-tagged E.coli His
    Human STAT3-281H Recombinant Human STAT3, GST-tagged Wheat Germ GST
    Human STAT3-282H Recombinant Human STAT3, GST-tagged Wheat Germ GST
    Human STAT3-29822TH Recombinant Human STAT3, His-tagged His
    Human STAT3-29823TH Recombinant Human STAT3, His-tagged E.coli His
    Human STAT3-30H Recombinant Human STAT3 protein, His-tagged E.coli His
    Human STAT3-316H Recombinant Human STAT3 protein, His-tagged Yeast His
    Human STAT3-31H Recombinant Human STAT3 protein, His-tagged E.coli His
    Human STAT3-335H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP
    Human STAT3-336H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP
    Human STAT3-337H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP
    Human STAT3-39228H Recombinant Human STAT3, GST-tagged E.coli GST
    Human STAT3-5975H Recombinant Human STAT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human STAT3-73H Recombinant Human Signal Transducer And Activator Of Transcription 3 E.coli N/A
    Human STAT3-951H Recombinant Human STAT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse STAT3-16109M Recombinant Mouse STAT3 Protein Mammalian Cell His
    Mouse Stat3-6170M Recombinant Mouse Stat3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Stat3-8593M Recombinant Mouse Stat3 protein, His-tagged E.coli His
    Rat STAT3-5778R Recombinant Rat STAT3 Protein Mammalian Cell His
    Chicken STAT3-2620C Recombinant Chicken STAT3 Mammalian Cell His
    Zebrafish STAT3-9038Z Recombinant Zebrafish STAT3 Mammalian Cell His
    Cattle STAT3-1735C Recombinant Cattle STAT3 protein, His-tagged E.coli His

    stat3 involved in several pathways and played different roles in them. We selected most pathways stat3 participated on our site, such as Chemokine signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with stat3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine signaling pathway Ccl21a; CCL4L1; GNG12; XCR1; GRK1; WAS; NCF1; AMCF-II; GNGT1; CCL2
    HIF- signaling pathway RELA; PFKL; ALDOA; GM5506; MTOR; PDHA2; MAP2K2; CAMK2D; PIK3R5; EP300
    FoxO signaling pathway AKT1; GRB2B; SETD7; GADD45AA; GRB2; BNIP4; FOXO1A; KLF2; IRS2; PRKAB1A
    Signaling pathways regulating pluripotency of stem cells ESX1; BMPR2; NANOG; BMP4; MAPK13; POU5F1; FZD1; AXIN2; LEFTY2; SMAD2
    Jak-STAT signaling pathway IFNA1; AOX4; MPL; MTOR; Ifna15; M17; JAK2A; CNTF; IFNA21; IL2RGB
    Prolactin signaling pathway NFKB1; PRLR; STAT5B; RAF1; STAT1; INS1; SHC3; SIRPA; PRP2; PIK3R1
    Adipocytokine signaling pathway G6PC3; NFKB1; ACSBG2; G6PC; TNFRSF1A; PCK2; NPY; PTPN11B; RXRAA; SLC2A4
    Insulin resistance PRKCB; MGEA5; MAPK8; RPS6KA3A; SLC2A4; INSRA; GFPT1; PYGM; OGT.1; RPS6KA2
    Toxoplasmosis TYK2; PIK3CA; HLA-DRB4; CD40LG; TGFB2; IRAK4; MAPK10; CYCS; Toxoplasma Gondii Profilin Family Protein; Toxoplasma Gondii Dense Granule Protein 7
    Hepatitis C TBK1; TRP53; MAPK1; OAS1B; CLDN18; OAS1; IFNA6; Ifna15; NR1H3; SCARB1
    Hepatitis B IFNA1; IFNA5; IFNA13; TGFB2; CXCL8; PRKCB; IKBKG; CCNE2; STAT2; BAD
    Measles IL4; IKBKE; Fasl; CD209C; IFNA2; EIF2AK1; OAS2; MX1; CD46; HSPA2
    Epstein-Barr virus infection YWHAZ; PRKACB; PSMD6; YWHAB; PSMD1; RAN; CD19; HSPA6; NFKBIB; NFKB1
    Pathways in cancer FGFR1; ROCK1; LAMC1; LAMB3; PDGFRB; CUL2; KRAS; STAT5B; MAX; FGF5
    Viral carcinogenesis ACTN1; HIST1H2BI; HDAC9; SCIN; TRAF5; GTF2A2; PIK3R5; HDAC11; GTF2H2C_2; RHOA
    Proteoglycans in cancer PTK2; CDC42; PIK3R1; FLNC; CAV3; PIK3R3; Fzd4; FZD10; CAV2; TFAP4
    MicroRNAs in cancer RECK; SLC7A1; CDC25A; MMP16; THBS1; TGFB2; CCNE2; NRAS; IGF2BP1; GLS
    Pancreatic cancer RELA; BRAF; TGFB1; IKBKG; PIK3R3; MAPK1; RALBP1; ARAF; TRP53; ARHGEF6
    Acute myeloid leukemia PIK3CG; AKT2; PML; SPI1; CHUK; RUNX1T1; PIK3R2; RAF1; SFPI1; STAT5B
    Inflammatory bowel disease (IBD) IL23; RORA; GATA3; TLR4; HLA-DOB; HLA-DRB3; IFNGR2; IL12A; TGFB3; IL22

    stat3 has several biochemical functions, for example, CCR5 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by stat3 itself. We selected most functions stat3 had, and list some proteins which have the same functions with stat3. You can find most of the proteins on our site.

    Function Related Protein
    CCR5 chemokine receptor binding JAK1; CCL4; STAT3; CCL5; CNIH4; CCL3
    DNA binding ZNF776; ATOH8; TCEANC; ANKRD1; GTF2F2A; TFDP3; SRRT; ZEB1B; HMGA2; RPL7
    RNA polymerase II core promoter proximal region sequence-specific DNA binding HINFP; FOSL2; NCOA2; TXK; MEIS1; NFKB2; MEOX1; E2F4; PITX2; TFE3B
    RNA polymerase II repressing transcription factor binding MIXL1; MTA1; RBPJ; HDAC1; TCERG1; TCF7L2; BBS1; MKKS; BBS10; GTF2A2
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding RORCA; NR1I2; NR2F2; NR1H2; NR2F1; NR2F6A; PPARG; RXRB; AHR; NR4A1
    glucocorticoid receptor binding STAT5B; GRIP1; CEBPB; NR4A2; ETS2; NRIP1; FKBP4; EP300; YWHAH; STAT3
    protein binding STAM2; C2orf63; COX5B; STAT5B; SLC22A6; AIM2; CTNND1; ERC2; FBF1; PHF10
    protein dimerization activity MYCL1; TXLNB; TFEC; HPSE; ERBB2; MESPBA; HER1; KIF9; ID4; AIFM1
    protein kinase binding TSKS; FGR; SQSTM1; CALM; ADCY6; SLC12A7; SNAP91; MAP2K3; STX1B; CNPPD1
    protein phosphatase binding RPA2; STAT3; SHOC2; PPP6R1; MET; CSF1R; MAP3K5; PARD3; SKAP1; GNB2L1
    signal transducer activity PPFIA1; GPR139; GHRHR2; GAB1; OLFR469; PLCD1A; PLCB2; V2RX1; SLC35B2; LPAR2B
    transcription factor activity, sequence-specific DNA binding XBP1; RXRBB; DMRTC2; TBX18; DMRT2B; ZNF649; ZNF7; TCF3A; SIN3A; ARNT
    transcription factor binding PBX1; GTF2A2; DNMT1; DOT1L; MLXIPL; PSMC5; TRIM6; SMARCA4; FOSB; RBL1
    transcription regulatory region DNA binding NKX2-5; GATA3; CARM1; MEF2C; SALL2; SMAD6; NCOR1; TAF2; CCNT1; OVOL2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GLI3; ONECUT3; PITX3; ZFAT; Ar; FOXA1; BSX; TFE3; MYC; ZNF750
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding RXRB; FOXO3; GATA6; MYOG; PKNOX1; SLAMF7; MAFG; ATF1; ATF2; SOHLH1

    stat3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with stat3 here. Most of them are supplied by our site. Hope this information will be useful for your research of stat3.

    EGFR; ERBB2

    Ye, F; Tang, CL; et al. MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. INTERNATIONAL JOURNAL OF CANCER 136:2120-2131(2015).
    Lu, K; Fang, XS; et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. CANCER LETTERS 359:250-258(2015).

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