STAT3 Protein

September 27-30, 2022

Boston Convention and Exhibition Center

Booth #336

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STAT3

Home / Products / STAT3

STAT3

Official Full Name Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)
Background The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.
Synonyms STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor
    • Species :
    • Cattle
    • Chicken
    • Human
    • Human, Mouse, Rat, Bos taurus; Cattle
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Insect Cell
    • Insect cells
    • Mamanlian cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • DYKDDDDK
    • Flag
    • GST
    • His
    • MBP
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STAT3-1496H Recombinant Human STAT3, GST-tagged Sf9 Insect Cell GST
    Human STAT3-29823TH Recombinant Human STAT3, His-tagged E.coli His
    Human STAT3-131H Recombinant Human STAT3 Mammalian Cell His
    Human STAT3-2172H Recombinant Human STAT3 E.coli N/A
    Human STAT3-2174H Recombinant Human STAT3, MYC/DDK-tagged HEK293 Myc/DDK
    Human STAT3-2175H Recombinant Human STAT3, MYC/DDK-tagged HEK293 Myc/DDK
    Human STAT3-2176H Recombinant Human STAT3, His-tagged E.coli His
    Human STAT3-281H Recombinant Human STAT3, GST-tagged Wheat Germ GST
    Human STAT3-282H Recombinant Human STAT3, GST-tagged Wheat Germ GST
    Human STAT3-29822TH Recombinant Human STAT3, His-tagged His
    Human STAT3-30H Recombinant Human STAT3 protein, His-tagged E.coli His
    Human STAT3-316H Recombinant Human STAT3 protein, His-tagged Yeast His
    Human STAT3-31H Recombinant Human STAT3 protein, His-tagged E.coli His
    Human STAT3-335H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP
    Human STAT3-336H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP
    Human STAT3-337H Recombinant Human STAT3 protein, His/MBP-tagged E.coli His/MBP
    Human STAT3-39228H Recombinant Human STAT3, GST-tagged E.coli GST
    Human STAT3-73H Recombinant Human Signal Transducer And Activator Of Transcription 3 E.coli N/A
    Mouse STAT3-16109M Recombinant Mouse STAT3 Protein Mammalian Cell His
    Mouse Stat3-8593M Recombinant Mouse Stat3 protein, His-tagged E.coli His
    Rat STAT3-5778R Recombinant Rat STAT3 Protein Mammalian Cell His
    Chicken STAT3-2620C Recombinant Chicken STAT3 Mammalian Cell His
    Zebrafish STAT3-9038Z Recombinant Zebrafish STAT3 Mammalian Cell His
    Cattle STAT3-1735C Recombinant Cattle STAT3 protein, His-tagged E.coli His
    Human STAT3-1417HCL Recombinant Human STAT3 293 Cell Lysate HEK293 N/A
    Human STAT3-1418HCL Recombinant Human STAT3 293 Cell Lysate HEK293 N/A
    Human STAT3-07H Recombinant Human STAT3 Protein, His-tagged Insect Cell His
    Human STAT3-1107H Recombinant Human STAT3 protein, His-tagged E.coli His
    Human STAT3-151H Recombinant Human STAT3 Protein, His-tagged Human cells His
    Human STAT3-152H Recombinant Human STAT3 Protein, His-tagged Human Cells His
    Human STAT3-153H Recombinant Human STAT3 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Rat Stat3-2107R Recombinant Rat Stat3 Protein, His-tagged E.coli N-His
    Human, Mouse, Rat, Bos taurus; Cattle STAT3-2837H Recombinant Human STAT3 Protein, His-tagged E.coli N-His
    Human STAT3-3533H Recombinant Human STAT3 protein, His-SUMO-tagged E.coli His-SUMO
    Human STAT3-4574HFL Recombinant Full Length Human STAT3, Flag-tagged Mamanlian cells Flag
    Human STAT3-001H Recombinant Human STAT3 Protein, His-tagged Insect cells His
    Human STAT3-138H Recombinant Human STAT3 Protein, His-tagged Insect Cell His
    Human STAT3-5975H Recombinant Human STAT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human STAT3-951H Recombinant Human STAT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Stat3-6170M Recombinant Mouse Stat3 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    STAT3 involved in several pathways and played different roles in them. We selected most pathways STAT3 participated on our site, such as Chemokine signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine signaling pathway GM1987; CCR1L1; PTK2; CXCR3; CCL2; GM13306; CCL15; CCR7; BRAF; CXCL9
    HIF- signaling pathway PIK3R5; EPO; EP300; PFKL; ALDOA; HK2; ANGPT4; HMOX1; IGF1R; HK1
    FoxO signaling pathway HRASA; MAPK14A; PIK3R5; CCNB3; SMAD2; TGFB3; SGK3; NLK; FBXO32; TGFB1A
    Signaling pathways regulating pluripotency of stem cells RAF1; MAPK3; MAPK12; INHBB; FZD1; Fzd4; WNT3A; IGF1; POU5F1; PCGF5
    Jak-STAT signaling pathway IFNA14; Il2; JAK2B; RAF1B; SOCS7; PIAS4A; IL4R; IL22; IFNA13; FHL1
    Prolactin signaling pathway MAPK10; IRF1; MAPK12; AKT2; MAPK8; PRL; AKT1; RELA; CSH; FOXO3
    Adipocytokine signaling pathway ADIPOR1B; G6PCA.2; IRS2; JAK2; LEPB; CPT1A; PPARGC1A; ACSBG2; CPT1B; AKT2
    Insulin resistance MAPK8A; PRKCBA; PPARGC1A; NFKBIAA; PCK2; GYS1; PRKCB; PTPRF; PRKAG2A; G6PC3
    Toxoplasmosis TNF; TRAF6; Toxoplasma Gondii Microneme Protein MIC3; HSPA1B; LAMA2; NFKBIA; PIK3CB; BCL2L1; PIK3CD; MAPK3
    Hepatitis C IRF7; IFNAR2; OAS1; TBK1; PPP2R2A; CLDN6; OAS2; RNASEL; PIK3R1; RELA
    Hepatitis B TGFB1; CREB3L3; FAS; TGFBR1; HRAS; MAPK10; IKBKG; NFKBIA; CCNE1; MYD88
    Measles TP73; CCND1; IFNA4; EIF3H; PIK3CD; TRAF6; CCNE2; MSN; HSPA2; STAT5B
    Epstein-Barr virus infection PSMD2; POLR3G; MAPK11; HSPA1B; POLR2G; POLR3F; HSPA2; RELA; FGR; MAP2K3
    Pathways in cancer AXIN2; FZD2; GNAQ; FGFR2; PTGER4; MSH6; GNAS; TP53; CBL; WNT8B
    Viral carcinogenesis TRAF1; PIK3R1; CCNA2; DLG1; ACTN4; NFKB1; VAC14; YWHAG; H2BFWT; PIK3R2
    Proteoglycans in cancer SOS1; HPSE; CAV3; MAPK1; DDX5; ANK2; MAP2K1; MAP2K2; PRKACG; LUM
    MicroRNAs in cancer SPRY2; SERPINB5; MDM4; CDC25C; TTC6; HRAS; Pdgfa&Pdgfb; CCNG1; MARCKS; ZEB1
    Pancreatic cancer TGFB3; PIK3CB; TRP53; MAPK8; MAPK1; NFKB1; VEGFA; IKBKG; MAPK10; RB1
    Acute myeloid leukemia RELA; MAP2K1; SFPI1; SPI1; STAT3; PIK3CB; PIM1; ZBTB16; PIK3CD; PPARD
    Inflammatory bowel disease (IBD) IL5; IL12A; H2-AA; IL4; HLA-DRB4; TNF; IFNGR2; IFNG; STAT6; HLA-DOA

    STAT3 has several biochemical functions, for example, CCR5 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT3 itself. We selected most functions STAT3 had, and list some proteins which have the same functions with STAT3. You can find most of the proteins on our site.

    Function Related Protein
    CCR5 chemokine receptor binding JAK1; CCL3; CCL4; CCL5; STAT3; CNIH4
    DNA binding ZBTB1; ZNF563; H1FNT; PRRX1B; NKX2.5; IRF2; NKX6.3; ZFP507; PIAS1; ZFP827
    RNA polymerase II core promoter proximal region sequence-specific DNA binding BCL11B; DLX5; MEOX2; RBPJB; MAFA; ELK3; FOSL1; NKX2-5; SPI1; JUNB
    RNA polymerase II repressing transcription factor binding GSC; BBS4; MTA2; TCERG1; TBX5A; TCF7L2; MIXL1; TTC8; SP1; RBBP8
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR5A1; NR2F6; NR6A1; RORC; NR4A2A; RORA; PPARA; ESRRA; NR2F1B; HNF4A
    glucocorticoid receptor binding EP300; ETS2; YWHAH; NRIP1; CEBPB; STAT3; NR4A2; STAT5B; FKBP4; GRIP1
    protein binding UPF3B; CCDC12; KRR1; NEK2; SOCS1; PPP3CC; PSENEN; FGFRL1B; LILRB4; DHX40
    protein dimerization activity OLIG3; KIF9; MEF2D; AHR; ASCL1B; HES2; ARNTL2; ARNTL; MYC; NCOA1
    protein kinase binding CDK5RAP2; NCS1; FOXO3; CAMK2N2; PRDX3; TRP53; AP2A2; FER; TEX14; NBEA
    protein phosphatase binding ROS1; NEK2; ITGA1; RPA3; KAT2A; ERBB2; ITPR1; ANAPC5; TRAF3; MAP2K7
    signal transducer activity VMN1R46; CD40; C18orf32; TAAR11; GNA12; VAPA; MAVS; CANT1; TNK1; GNA13
    transcription factor activity, sequence-specific DNA binding RORAA; FOXI3A; FLI1; RORB; TCF3; SP140; TCEAL1; RARG; TRIM22; ZNF189
    transcription factor binding HDAC9; EGR1; HYAL1; GNPTAB; DRAP1; SNF8; HDAC8; JUNBA; EPN1; E2F5
    transcription regulatory region DNA binding FOXC1; ATF3; TBL1X; XRCC6; RCOR1; HIVEP2; GABPB1; FOXC2; HDAC1; H2AFY
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PLAG1; NOBOX; SOX12; BCL11B; NPAS4; ISL1; HEYL; PBX1; EBF1; FOXI1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding FOXF1; BARHL1B; CREB3L3; FOXO3; ATF3; NHLH1; ONECUT3; GATA2; PPARG; LMO2

    STAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT3.

    EGFR; ERBB2

    Ye, F; Tang, CL; et al. MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. INTERNATIONAL JOURNAL OF CANCER 136:2120-2131(2015).
    Lu, K; Fang, XS; et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. CANCER LETTERS 359:250-258(2015).

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