stat3
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  • Official Full Name
  • Signal Transducer And Activator Of Transcription 3 (Acute-Phase Response Factor)
  • Background
  • The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.
  • Synonyms
  • STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); APRF; HIES; FLJ20882; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; DNA-binding protein APRF; acute-phase response factor
Cat.#:STAT3-001HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human STAT3 Protein, His-tagged
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Cat.#:STAT3-138HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human STAT3 Protein, His-tagged
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Cat.#:STAT3-131HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human STAT3
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Cat.#:STAT3-1496HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-2172HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3
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Cat.#:STAT3-2174HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT3, MYC/DDK-tagged
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Cat.#:STAT3-2175HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT3, MYC/DDK-tagged
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Cat.#:STAT3-2176HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-281HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-282HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-29822THTag:His
Source (Host):Species:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-29823THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, His-tagged
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Cat.#:STAT3-30HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His-tagged
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Cat.#:STAT3-316HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human STAT3 protein, His-tagged
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Cat.#:STAT3-335HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-336HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-337HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3 protein, His/MBP-tagged
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Cat.#:STAT3-39228HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT3, GST-tagged
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Cat.#:STAT3-73HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Signal Transducer And Activator Of Transcription 3
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Cat.#:STAT3-16109MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STAT3 Protein
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Cat.#:Stat3-8593MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Stat3 protein, His-tagged
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Cat.#:STAT3-5778RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STAT3 Protein
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Cat.#:STAT3-2620CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STAT3
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Cat.#:STAT3-9038ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STAT3
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Cat.#:STAT3-1735CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle STAT3 protein, His-tagged
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Cat.#:STAT3-1417HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human STAT3 293 Cell Lysate
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Cat.#:STAT3-1418HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human STAT3 293 Cell Lysate
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Involved Pathway

STAT3 involved in several pathways and played different roles in them. We selected most pathways STAT3 participated on our site, such as Chemokine signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
CXCL3; CCR8; CCL22; DOCK2; CCL4L1; NFKB1; MAPK1; SHC1; CXCL6; CXCL12
HIF- signaling pathway
ENO1; PLCG1; IL6R; VEGFA; NOX3; PDHA1; VHL; GM5506; CAMK2B; EPO
FoxO signaling pathway
HOMER3; HRAS; MAPK10; SOD2; FOXO3B; HRASA; AKT2L; FOXO3A; GABARAPL2; INSRB
Signaling pathways regulating pluripotency of stem cells
PCGF1; GSK3B; FZD7; FZD9; MAP2K2; WNT3A; LHX5; GRB2; HESX1; PCGF3
Jak-STAT signaling pathway
IL2RB; IL11; M17; IFNB; IL12A; IFNE; AOX3L1; IFNA14; STAM; EP300
Prolactin signaling pathway
FOXO3; LHCGR; MAPK12; MAPK9; CCND2; RELA; AKT1; GALT; MAPK10; STAT5A
Adipocytokine signaling pathway
PRKAG2; LEPR; CHUK; PRKAB2; ACSL3B; ACSL3A; ACSL1A; TRAF2; LEPA; PPARGC1A
Insulin resistance
MAPK10; IRS2; SLC2A2; PTENB; SLC2A1A; GYS2; G6PCA.2; RPS6KB1B; PYGMA; MAPK8A
Toxoplasmosis
MAPK11; IRGM; IRGM1; PIK3R2; MAPK1; IFNG; BIRC7; IL12B; TNF; MAPK10
Hepatitis C
CLDN18; MAPK13; MAPK11; LDLR; CLDN1; EIF2AK1; CD81; TRADD; GSK3B; RXRA
Hepatitis B
TLR4; ATP6AP1; BAD; STAT1; CREB3L3; DDX58; PIK3CA; TGFB2; STAT5B; FAS
Measles
OAS1B; IFNGR2; IFNA12; TNFRSF10D; RCHY1; IFNG; STAT3; Ifna15; IL12A; CD3G
Epstein-Barr virus infection
SND1; PRKACG; RAN; XPO1; PIK3CG; TAB1; HLA-B; POLR2C; PRKACB; POLR3H
Pathways in cancer
FGFR1; STK36; FLT3LG; ARAF; EP300; WNT1; TP53; PRKACB; RALBP1; FGF6
Viral carcinogenesis
TBPL2; HIST1H4M; PRKACA; H2BFWT; HIST2H4A; CDC42; HIST1H4G; GTF2H3; EP300; Casp3
Proteoglycans in cancer
RDX; SMAD2; ARHGEF12; PPP1R12A; PPP1R12C; IL12B; ESR1; ERBB4; TGFB2; IGF1
MicroRNAs in cancer
WNT3; NFKB1; RPS6KA5; TRP63; CD44; PRKCG; APC2; SERPINB5; ATM; SOX4
Pancreatic cancer
ERBB2; VEGFA; PIK3CG; AKT1; SMAD2; TGFB3; TGFA; SMAD4; NFKB1; RAD51
Acute myeloid leukemia
CHUK; RUNX1; BRAF; ZBTB16; IKBKB; PIK3R5; PIM2; STAT5A; AKT3; PIM1
Inflammatory bowel disease (IBD)
HLA-DMA; HLA-DRB3; IL17F; SMAD2; SMAD3; STAT1; IL17A; IFNG; HLA-DQB1; IL1B

Protein Function

STAT3 has several biochemical functions, for example, CCR5 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT3 itself. We selected most functions STAT3 had, and list some proteins which have the same functions with STAT3. You can find most of the proteins on our site.
Function
Related Protein
Function CCR5 chemokine receptor binding
Related Protein JAK1; STAT3; CCL3; CCL4; CNIH4; CCL5
Function DNA binding
Related Protein TCEA2; GTF2F2; RXRBB; DLX6A; PPARAB; HOXD12; ZBTB41; NR1D1; DNAJC2; SWAP70
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein DDIT3; FIGLA; MAFA; CRX; TBX3; NFIC; MESP1; BCL11B; MYOG; NKX6
Function RNA polymerase II repressing transcription factor binding
Related Protein MTA1; TBX5A; TCERG1; TBP; STAT3; RBBP8; GTF2A2; GATA6; BBS1; PPARA
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein NR1H3; NR2F1B; ESRRB; HNF4G; NR2F1; NR5A1; PPARG; PPARD; PGR; NR4A2A
Function glucocorticoid receptor binding
Related Protein STAT5B; NR4A2; GRIP1; EP300; YWHAH; CEBPB; ETS2; FKBP4; STAT3; NRIP1
Function protein binding
Related Protein VPS8; CARHSP1; RPL5; KRAS; BBS10; RUFY4; MAPK15; ODF1; UBE2E3; ABCG1
Function protein dimerization activity
Related Protein HER7; PRKRIR; MYCL1; STK4; BHLHE41; CELSR1; BTRC; FBXW11B; HIF1AL2; POLR1C
Function protein kinase binding
Related Protein STAP1; BCL10; NME2; PTPRJ; MLKL; NEFH; TRAP1; PPP1R15A; KAT2B; FBXO5
Function protein phosphatase binding
Related Protein ANAPC5; ANAPC7; PPARG; MET; DRD1; CDH2; TP53; CSK; CTNNB1; STAT3
Function signal transducer activity
Related Protein SH2B3; DRD2A; OLFR1013; PRMT2; PTK2AA; GNB3; PLCH1; TAS2R200.1; CXCR3.2; MIER1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ATOH8; ZHX3; ZKSCAN4; ZNF668; SALL3B; PFDN1; LEF1; ASCL2; SCAND2P; ZIC5
Function transcription factor binding
Related Protein TFAP2A; SIRT2; PURB; SMARCA4; DRG1; JUNB; JUNBA; GTF2A2; MED6; MYC
Function transcription regulatory region DNA binding
Related Protein CCNT1; ARRB1; TAF7; SREBF1; MTERF3; SIX1; DLX5; RREB1; TP53; Ar
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CEBPE; MEF2C; BSX; SOX12; HNF4A; TP63; BCL11B; ESR1; GATA3; GLI2
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein FOXF2; MYOD1; ATF1; GATA1; ZGLP1; MYOG; GATA1A; BARHL1B; PAX9; NR1I3

Interacting Protein

STAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT3.
EGFR; ERBB2

STAT3 Related Articles

Ye, F; Tang, CL; et al. MDM2-dependent positive-feedback loop is involved in inhibition of miR-375 and miR-106b induced by Helicobacter pylori lipopolysaccharide. INTERNATIONAL JOURNAL OF CANCER 136:2120-2131(2015).
Lu, K; Fang, XS; et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. CANCER LETTERS 359:250-258(2015).

STAT3 Related Gene Family

TGF Cytokines