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| Cat.: | TGFBR2-377H |
| Cat.No.: | TGFBR2-377H |
| Product Overview: | Recombinant Human TGFBR2 Protein (NP_003233.4) (Met1-Gln166) was produced by Baculovirus-Insect Cells expression system. This protein was expressed with a polyhistidine tag at the C-terminus. |
| Description: | TGFBR2 is member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised by a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity. |
| Source: | Baculovirus-Insect Cells |
| Species: | Human |
| Tag : | His |
| Predicted N Terminal: | Ile 23 |
| Form: | Lyophilized from sterile 20 mM PBS, pH 7.0, 150 mM NaCl，10 %glycerol,0.5 mM TCEP. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Molecular Mass: | The recombinant human TGFBR2 consists of 154 amino acids and predicts a molecular mass of 17.7 kDa. |
| Protein length: | Met1-Gln166 |
| Endotoxin: | < 1.0 EU per μg protein as determined by the LAL method. |
| Purity: | > 95 % as determined by SDS-PAGE. |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70 centigrade. |
| Storage: | Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
| Shipping: | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
| Gene Name: | TGFBR2 transforming growth factor, beta receptor II (70/80kDa) [ Homo sapiens ] |
| Official Symbol: | TGFBR2 |
| Synonyms: | TGFBR2; tbetaR-II; AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; |
| Gene ID: | 7048 |
| mRNA Refseq: | NM_001024847 |
| Protein Refseq: | NP_001020018 |
| MIM: | 190182 |
| UniProt ID: | P37173 |
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