| Official Full Name | transforming growth factor, beta receptor II (70/80kDa) |
| Background | This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008] |
| Synonyms | TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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TGFBR2 involved in several pathways and played different roles in them. We selected most pathways TGFBR2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RAF1B; MAP3K3; MAP2K5; TRAF2; GADD45AA; CACNB3A; PRKACBB; TNF; CACNG6; RRAS |
| Cytokine-cytokine receptor interaction | PDGFRB; TGFB3; CCL3L1; CCR8L; LIF; AMHR2; BMPR1A; IL2RGA; TNFSF10; TGFBR1B |
| FoxO signaling pathway | FOXG1A; PRKAA1; FOXO6; TGFBR2; CCNB2; AKT3A; AGAP2; RAF1B; NLK; ARAF |
| Endocytosis | SMAP2; PLD1; ARPC1B; LDLRAP1A; KITB; MVB12BB; EHD2; PLD1A; PARD6GB; PIP5K1B |
| TGF-beta signaling pathway | BMPR1AB; TGFBR2; NOG2; AMH; GDF5; BMP7B; INHBC; MAPK1; ZFYVE16; LFT1 |
| Osteoclast differentiation | MAP2K7; MAPK13; IL1B; LILRA2; SIRPG; PIK3R3; PPP3R1; IKBKG; SIRPB1; IKBKB |
| Hippo signaling pathway | AXIN1; BMPR1A; SMAD7; SOX2; WNT2B; WNT2; LLGL1; YAP1; BMP6; ITGB2L |
| Adherens junction | IGF1R; INSRB; ACTN2B; PTPRJA; CDC42L; PTBP3; NLK; SSX2IP; CTNNB1; PVRL4 |
| Chagas disease (American trypanosomiasis) | MAPK12; IFNB1; PLCB4; GNA11; CD3G; CD3E; C3; TNF; PPP2R1B; PIK3R2 |
| HTLV-I infection | NFKBIA; VDAC1; IKBKG; DVL1; NFATC2; MYBL2; EP300; LCK; HLA-E; FDPS |
| Pathways in cancer | HHIP; BDKRB1; CTNNA3; PTK2; BRAF; BIRC8; NFKB2; FGF20; BAX; FLT3LG |
| Transcriptional misregulation in cancer | FLI1; LMO2; TLX3; SSX2; MLL1; ZEB1; HIST3H3; CCND2; CD86; TRP53 |
| Colorectal cancer | TP53; BAX; PIK3R1; TGFB1; PIK3CA; RHOA; PIK3CB; PIK3R3; PIK3CG; RAC2 |
| Pancreatic cancer | RALBP1; MAPK9; STAT3; RAC1; CCND1; RELA; TP53; PIK3R1; PLD1; NFKB1 |
| Chronic myeloid leukemia | ARAF; IKBKB; HRAS; BRAF; HDAC2; TGFBR1; PIK3R3; PTPN11; SHC4; STAT5A |
TGFBR2 has several biochemical functions, for example, ATP binding, SMAD binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR2 itself. We selected most functions TGFBR2 had, and list some proteins which have the same functions with TGFBR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | Aatk; ABCB1; KLHL8; MYH1E; NEK7; ERBB4; MARK2; SLC27A2; ROCK1; KATNAL2 |
| SMAD binding | STUB1; TGFBR2; ACVR1; SKOR1; TGFBR3; COL1A2; PURA; EP300; BMP2; USP15 |
| glycosaminoglycan binding | CCDC80; ENG; BGN; SPOCK3; SERPINE2; TGFBR3; TGFBR2; EGFLAM; SPOCK2; SERPINA5 |
| metal ion binding | CPEB1B; DGKD; PPP2CA; ZNF200; PHC2A; PM20D1.2; AMPD1; STAMBPL1; ZNF292A; BA1 |
| protein binding | MYZAP; FAM32A; FOXG1; SEMA7A; KRTAP5-9; FCHSD2; C11orf49; ATP6V1C1; PTGES2; ZBTB43 |
| receptor signaling protein serine/threonine kinase activity | BMPR1BB; TGFBR1B; STK25B; BMPR1A; ACVR1; ACVR1B; ACVR1L; TGFBR1; ALPK2; BMPR2 |
| transforming growth factor beta binding | LTBP1; ENG; ITGAV; TGFB3; CD109; ACVR1; TGFBR1; HYAL2; LTBP4; TGFBR3 |
| contributes_to transforming growth factor beta binding | TGFBR3; ENG; TGFBR2; TGFBR1 |
| transforming growth factor beta receptor activity, type II | AMHR2; TGFBR2 |
| transforming growth factor beta-activated receptor activity | ACVRL1; TGFBR2; ENG; BMPR2A; TGFBR1; BMPR2B; TGFBR3; LTBP1 |
| transmembrane receptor protein serine/threonine kinase activity | TGFBR2; ACVR1; ACVR2AA; BMPR1A; ALPK2; ACVR1B; TGFBR1B; BMPR2B; ACVR1L; BMPR1BB |
| type I transforming growth factor beta receptor binding | TGFB1; SMAD2; SNX25; TGFBR2; FKBP1A; SMAD7; TGFB3; ENG; SMAD6 |
| type III transforming growth factor beta receptor binding | TGFB3; TGFB1; TGFBR2; TGFB2 |
TGFBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR2.
TGFB1; TGFB3; SCUBE3
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