TGFBR2

  • Official Full Name

    transforming growth factor, beta receptor II (70/80kDa)

  • Overview

    This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Sf9 Insect Cell
  • C
  • Fc
  • hFc
  • hIgG
  • His
  • mFc
  • Avi
  • Fc Chimera
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • His (Fc)
  • Myc
  • His|T7
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TGFBR2-697H Active Recombinant Human TGFBR2, Fc-tagged, Biotinylated Human Cell Fc
Human TGFBR2-646H Active Recombinant Human TGFBR2, Fc Chimera Mammalian cells Fc Chimera
Human TGFBR2-923H Active Recombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa) Human N/A
Human TGFBR2-05H Recombinant Human TGFBR2 Protein, 23-166aa, C-hIgG-His tagged Insect cells C-hIgG-His 23-166aa
Human TGFBR2-229H Recombinant Human TGFBR2 protein, Fc-tagged HEK293 Fc
Human TGFBR2-151H Recombinant Human TGFBR2, Fc Chimera HEK293 Fc
Human TGFBR2-152H Recombinant Human TGFBR2, Fc-His tagged Human Cell Fc/His
Human TGFBR2-1684H Recombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa) Mammalian cells N/A
Human TGFBR2-444H Recombinant Human TGFBR2, GST-tagged, Active Sf9 Insect Cell GST
Human TGFBR2-159H Recombinant Human TGFBR2 protein(Met1-Asp159), hFc-tagged HEK293 C-hFc Met1-Asp159
Human TGFBR2-2842HCL Recombinant Human TGFBR2 cell lysate Human Cell N/A
Human TGFBR2-377H Active Recombinant Human TGFBR2 protein(Met1-Gln166), His-tagged Insect Cells C-His Met1-Gln166
Human TGFBR2-0797H Active Recombinant Human TGFBR2 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Thr23-Asp159
Human TGFBR2-4439H Recombinant Human TGFBR2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TGFBR2-703H Recombinant Human TGFBR2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TGFBR2-173H Recombinant Human TGFBR2 protein, Fc-tagged HEK293 Fc Ile24-Asp159
Human TGFBR2-909HFL Recombinant Full Length Human TGFBR2 Protein, C-Flag-tagged Mammalian cells Flag
Human TGFBR2-453H Recombinant Human TGFBR2 Protein, Fc-tagged HEK293 Fc 567
Human TGFBR2-1290H Recombinant Human TGFBR2 Protein (L50-D159), His tagged E.coli His L50-D159
Human TGFBR2-209H-B Recombinant Human TGFBR2 Protein Pre-coupled Magnetic Beads HEK293
Human TGFBR2-1251H Active Recombinant Human TGFBR2 protein, hFc&His-tagged HEK293 hFc&His Thr23-Asp159
Human TGFBR2-1291H Recombinant Human TGFBR2 Protein (L50-D159), Tag Free E.coli No tag L50-D159
Human TGFBR2-0795H Active Recombinant Human TGFBR2 protein, His-tagged HEK293 His Thr23-Asp159
Human TGFBR2-6435H Recombinant Human TGFBR2 Protein (Thr23-Asp159), C-Fc tagged Mammalian cells C-Fc Thr23-Asp159
Human TGFBR2-209H Recombinant Human TGFBR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TGFBR2-1384H Recombinant Human TGFBR2 protein(Met1-Asp159), His&hFc-tagged, Biotinylated HEK293 C-His&hFc Met1-Asp159
Human TGFBR2-0796H Active Recombinant Human TGFBR2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Thr23-Asp159
Human TGFBR2-237H Recombinant Human TGFBR2 Protein, Ile24-Asp159, C-mFc-Avi tagged, Biotinylated HEK293 C-mFc-Avi Ile24-Asp159
Human TGFBR2-2765H Recombinant Human TGFBR2 Protein, His-tagged E.coli N-His Thr23-Gln166
Human TGFBR2-304H Recombinant Human TGFBR2 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Thr23-Asp159
Mouse Tgfbr2-6816M Active Recombinant Mouse Tgfbr2 Protein(Ile24-Asp159), hFc-tagged HEK293 hFc Ile24-Asp159
Mouse Tgfbr2-6817M Active Recombinant Mouse Tgfbr2 Protein(Ile24-Asp159), His-tagged HEK293 His Ile24-Asp159
Mouse Tgfbr2-8188M Recombinant Mouse Tgfbr2 protein, His & T7-tagged E.coli His/T7 Ile209~Thr590 (Accession # Q62312)
Mouse Tgfbr2-1778M Recombinant Mouse Transforming Growth Factor, Beta Receptor II Mammalian cells N/A
Mouse Tgfbr2-10618M Recombinant Mouse Tgfbr2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tgfbr2-6393M Recombinant Mouse Tgfbr2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tgfbr2-15M Recombinant Mouse Tgfbr2(Ile24-Asp184) Protein, C-Fc-tagged HEK293 Fc
Mouse Tgfbr2-02M Active Recombinant Mouse Tgfbr2 Protein (Ile24-Asp184), hFc-tagged NS0 C-mFc Ile24-Asp184
Mouse Tgfbr2-01M Active Recombinant Mouse Tgfbr2 Protein (Ile24-Asp184), mFc-tagged NS0 C-hFc Ile24-Asp184
Mouse TGFBR2-0794M Active Recombinant Mouse TGFBR2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ile24-Asp184
Mouse Tgfbr2-10618M-B Recombinant Mouse Tgfbr2 Protein Pre-coupled Magnetic Beads HEK293
Rat TGFBR2-6039R Recombinant Rat TGFBR2 Protein Mammalian Cell His
Rat Tgfbr2-8722R Active Recombinant Rat Tgfbr2 protein(Met1-Gln166), hFc-tagged HEK293 C-hFc Met1-Gln166
Rat TGFBR2-1374RCL Recombinant Rat TGFBR2 cell lysate Human Cell N/A
Rat TGFBR2-5696R Recombinant Rat TGFBR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tgfbr2-2261R Recombinant Rat Tgfbr2 protein, His&Myc-tagged Insect Cell His&Myc 24-166aa
Rat Tgfbr2-3573R Recombinant Rat Tgfbr2 protein, His&Myc-tagged E.coli His&Myc 24-166aa
Rat TGFBR2-5696R-B Recombinant Rat TGFBR2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey TGFBR2-8814C Recombinant Cynomolgus TGFBR2, Fc tagged Human Cell Fc
Cynomolgus Monkey TGFBR2-1291CCL Recombinant Cynomolgus TGFBR2 cell lysate Human Cell N/A
Homo sapiens (Human) RFL14015HF Recombinant Full Length Human Tgf-Beta Receptor Type-2(Tgfbr2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-567)
Rattus norvegicus (Rat) RFL33850RF Recombinant Full Length Rat Tgf-Beta Receptor Type-2(Tgfbr2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-567)
Rhesus TGFBR2-464R Active Recombinant Rhesus TGFBR2 protein, hFc-tagged HEK293 hFc Met1-Asp159
Rhesus TGFBR2-8814R Active Recombinant Rhesus TGFBR2, Fc tagged HEK293 Fc Met1-Asp159
Rhesus Macaque TGFBR2-4689R Recombinant Rhesus monkey TGFBR2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TGFBR2-4503R Recombinant Rhesus Macaque TGFBR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TGFBR2-4503R-B Recombinant Rhesus Macaque TGFBR2 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL7721SF Recombinant Full Length Pig Tgf-Beta Receptor Type-2(Tgfbr2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-297)
Zebrafish TGFBR2-9644Z Recombinant Zebrafish TGFBR2 Mammalian Cell His
Chicken TGFBR2-6979C Recombinant Chicken TGFBR2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TGFBR2 Related Signal Pathway

TGFBR2 involved in several pathways and played different roles in them. We selected most pathways TGFBR2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPLA2G4C;CASP3B;TGFB1A;RAF1;RAP1AB;NRAS;TRP53;HRASA;TGFB1
Cytokine-cytokine receptor interactionCCR6;TNFRSF10A;IFNA8;CCL19;CCL1;PDGFAB;TNFRSF12A;GDF5;Ccl21a
FoxO signaling pathwayPTEN;SOS1;CDKN2D;CDKN1BB;PIK3R3B;MAPK8;MAP2K2B;PRKAG3B;RAF1
EndocytosisPSD2;SMURF2;CHMP2B;TFR1A;STRUMPELLIN;CYTH1;VPS28;GRK1A;VPS37B
TGF-beta signaling pathwayBMP7B;ID2A;ACVR1L;TNF;TGFB2;CUL1;TGIF1;SMAD4;FSTA
Osteoclast differentiationCAMK4;IL1R1;LILRB3;CALCR;MAPK9;TNF;IKBKG;NOX1;TNFRSF11A
Hippo signaling pathwayACTG1;WNT3;WWC1;PPP2R1A;PARD6A;TGFB3;APC2;LIMD1;BMPR1B
Adherens junctionTGFBR2;WASF3B;SMAD4;PVRL3B;TJP1;Fert2;WASL;CTNNA1;RHOAD
Chagas disease (American trypanosomiasis)MAPK12;MAPK13;Ccl12;CD3D;TGFB1;IL1B;IKBKG;GNAI1;CCL2
HTLV-I infectionBUB3;DVL3;FZD2;HLA-DRA;FZD1;ANAPC11;FZD10;TNF;KRAS
Pathways in cancerWNT3A;HDAC1;RALBP1;EGLN1;FGF1;MSH2;GNG12;GNAI1;TPR
Transcriptional misregulation in cancerETV6;ETV4;FLI1;Pdgfa&Pdgfb;JMJD1C;HDAC2;HIST2H3C2;HIST1H3H;BMI1
Colorectal cancerRAF1;TCF7;DCC;TGFB3;PIK3CG;PIK3CB;FOS;PIK3CD;RAC1
Pancreatic cancerARAF;BAD;SMAD2;TRP53;BRCA2;NFKB1;PIK3R5;RAC3;IKBKG
Chronic myeloid leukemiaBAD;SMAD3;TGFBR2;TRP53;PIK3R3;PTPN11;TGFB2;RB1;SHC2

TGFBR2 has several biochemical functions, for example, ATP binding, SMAD binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR2 itself. We selected most functions TGFBR2 had, and list some proteins which have the same functions with TGFBR2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTAF1;RTCD1;RPS6KA1;MAGI1;CLPXA;MASTL;ALK;ERBB3B;STK24A
SMAD bindingSKOR1;COL1A2;USP15;TCF12;HIPK2;TGFBR1;SMAD2;CREBBP;MAGI2
glycosaminoglycan bindingENG;HABP2;SPOCK2;TGFBR3;VCAN;BGN;SERPINA5;CCDC80;Shh
metal ion bindingTRIM43B;ZNF823;ZNF263;TSHZ3;EXTL2;RTEL1;GFI1AA;NR2F1B;MOXD1L
protein bindingEPO;C1orf35;SLX4;TEAD2;TRPC1;HSPA1B;ZNF490;TRIM72;DHX38
receptor signaling protein serine/threonine kinase activityACVR1BA;ALPK2;STK39;SBK3;STK24B;BMPR1BA;ACVR1C;STK24A;TGFBR2
transforming growth factor beta bindingTGFBR1;ACVRL1;HYAL2;ACVR1;TGFB3;VASN;LTBP4;ITGAV;CD109
contributes_to transforming growth factor beta bindingTGFBR3;TGFBR2;ENG;TGFBR1
transforming growth factor beta receptor activity, type IITGFBR2;AMHR2
transforming growth factor beta-activated receptor activityBMPR2B;TGFBR3;TGFBR1;LTBP1;TGFBR2;ACVRL1;BMPR2A;ENG
transmembrane receptor protein serine/threonine kinase activityBMPR1BB;ACVR1BA;BMPR1BA;ACVR1;ACVR1B;ACVR2AA;BMPR1AA;TGFBR1A;BMPR1AB
type I transforming growth factor beta receptor bindingTGFB1;SMAD2;TGFBR2;ENG;TGFB3;FKBP1A;SMAD6;SNX25;SMAD7
type III transforming growth factor beta receptor bindingTGFB2;TGFB3;TGFB1;TGFBR2

TGFBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR2.

TGFB1; TGFB3; SCUBE3

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is TGFBR2 linked to autoimmune diseases? 04/26/2023

Dysregulation of TGF-beta signaling, including TGFBR2, has been associated with autoimmune diseases. Understanding these pathways may provide insights into developing targeted therapies.

Are there clinical trials targeting TGFBR2? 01/12/2020

Yes, there are ongoing clinical trials exploring the modulation of TGFBR2 for various conditions, including cancer and fibrotic diseases.

How does TGFBR2 affect cardiovascular health? 12/13/2019

TGFBR2 is involved in cardiovascular development and homeostasis. Dysregulation can contribute to conditions like aortic aneurysms and other cardiovascular diseases.

Is TGFBR2 involved in neurological disorders? 01/14/2019

Some studies suggest a potential link between TGFBR2 and neurological disorders. Further research is ongoing to understand its role in conditions like Alzheimer's and Parkinson's disease.

Can TGFBR2 be a therapeutic target for fibrotic diseases? 01/19/2018

Yes, TGFBR2 is implicated in fibrosis, and targeting it may offer therapeutic options for diseases characterized by excessive tissue scarring.

Customer Reviews (3)

Write a review
Reviews
04/14/2023

    TGFBR2 protein's remarkable performance in ELISA and protein electron microscopy structure analysis positions it as a valuable tool in various fields, including cardiovascular research, developmental biology, and molecular medicine.

    12/13/2022

      TGFBR2 protein's utility extends to protein electron microscopy structure analysis, where it plays a crucial role in investigating the detailed architecture and conformational changes of proteins.

      06/25/2021

        TGFBR2 protein is highly recommended for use in various research applications, including ELISA and protein electron microscopy structure analysis.

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