TGFBR2

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TGFBR2

Official Full Name transforming growth factor, beta receptor II (70/80kDa)
Background This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Synonyms TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • GST
    • His&Myc
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Tgfbr2-15M Recombinant Mouse Tgfbr2(Ile24-Asp184) Protein, C-Fc-tagged HEK293 Fc
    Rat Tgfbr2-2261R Recombinant Rat Tgfbr2 protein, His&Myc-tagged Insect Cell His&Myc
    Rat Tgfbr2-3573R Recombinant Rat Tgfbr2 protein, His&Myc-tagged E.coli His&Myc
    Human TGFBR2-151H Recombinant Human TGFBR2, Fc Chimera HEK293 Fc
    Human TGFBR2-152H Recombinant Human TGFBR2, Fc-His tagged Human Cell Fc/His
    Human TGFBR2-159H Recombinant Human TGFBR2 Protein, Fc tagged HEK293 Fc
    Human TGFBR2-1684H Recombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa) Mammalian cells N/A
    Human TGFBR2-173H Recombinant Human TGFBR2 protein, Fc-tagged HEK293 Fc
    Human TGFBR2-229H Recombinant Human TGFBR2 protein, Fc-tagged HEK293 Fc
    Human TGFBR2-2842HCL Recombinant Human TGFBR2 cell lysate Human Cell N/A
    Human TGFBR2-377H Recombinant Human TGFBR2 Protein (Met1-Gln166), His-tagged Insect Cell His
    Human TGFBR2-4439H Recombinant Human TGFBR2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TGFBR2-444H Recombinant Human TGFBR2, GST-tagged, Active Sf9 Insect Cell GST
    Human TGFBR2-646H Recombinant Human TGFBR2, Fc Chimera Mammalian cells Fc Chimera
    Human TGFBR2-697H Recombinant Human TGFBR2, Fc-tagged, Biotinylated Human Cell Fc
    Human TGFBR2-703H Recombinant Human TGFBR2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TGFBR2-923H Recombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa) Human N/A
    Mouse Tgfbr2-1778M Recombinant Mouse Transforming Growth Factor, Beta Receptor II Mammalian cells N/A
    Mouse Tgfbr2-6393M Recombinant Mouse Tgfbr2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Tgfbr2-8188M Recombinant Mouse Tgfbr2 protein, His & T7-tagged E.coli His/T7
    Rat TGFBR2-1374RCL Recombinant Rat TGFBR2 cell lysate Human Cell N/A
    Rat TGFBR2-6039R Recombinant Rat TGFBR2 Protein Mammalian Cell His
    Rat Tgfbr2-8722R Recombinant Rat Tgfbr2, Fc tagged Human Cell Fc
    Cynomolgus Monkey TGFBR2-1291CCL Recombinant Cynomolgus TGFBR2 cell lysate Human Cell N/A
    Cynomolgus Monkey TGFBR2-8814C Recombinant Cynomolgus TGFBR2, Fc tagged Human Cell Fc
    Rhesus Macaque TGFBR2-4689R Recombinant Rhesus monkey TGFBR2 Protein, His-tagged Mammalian Cell His
    Chicken TGFBR2-6979C Recombinant Chicken TGFBR2 Mammalian Cell His
    Zebrafish TGFBR2-9644Z Recombinant Zebrafish TGFBR2 Mammalian Cell His

    TGFBR2 involved in several pathways and played different roles in them. We selected most pathways TGFBR2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway RAF1B; MAP3K3; MAP2K5; TRAF2; GADD45AA; CACNB3A; PRKACBB; TNF; CACNG6; RRAS
    Cytokine-cytokine receptor interaction PDGFRB; TGFB3; CCL3L1; CCR8L; LIF; AMHR2; BMPR1A; IL2RGA; TNFSF10; TGFBR1B
    FoxO signaling pathway FOXG1A; PRKAA1; FOXO6; TGFBR2; CCNB2; AKT3A; AGAP2; RAF1B; NLK; ARAF
    Endocytosis SMAP2; PLD1; ARPC1B; LDLRAP1A; KITB; MVB12BB; EHD2; PLD1A; PARD6GB; PIP5K1B
    TGF-beta signaling pathway BMPR1AB; TGFBR2; NOG2; AMH; GDF5; BMP7B; INHBC; MAPK1; ZFYVE16; LFT1
    Osteoclast differentiation MAP2K7; MAPK13; IL1B; LILRA2; SIRPG; PIK3R3; PPP3R1; IKBKG; SIRPB1; IKBKB
    Hippo signaling pathway AXIN1; BMPR1A; SMAD7; SOX2; WNT2B; WNT2; LLGL1; YAP1; BMP6; ITGB2L
    Adherens junction IGF1R; INSRB; ACTN2B; PTPRJA; CDC42L; PTBP3; NLK; SSX2IP; CTNNB1; PVRL4
    Chagas disease (American trypanosomiasis) MAPK12; IFNB1; PLCB4; GNA11; CD3G; CD3E; C3; TNF; PPP2R1B; PIK3R2
    HTLV-I infection NFKBIA; VDAC1; IKBKG; DVL1; NFATC2; MYBL2; EP300; LCK; HLA-E; FDPS
    Pathways in cancer HHIP; BDKRB1; CTNNA3; PTK2; BRAF; BIRC8; NFKB2; FGF20; BAX; FLT3LG
    Transcriptional misregulation in cancer FLI1; LMO2; TLX3; SSX2; MLL1; ZEB1; HIST3H3; CCND2; CD86; TRP53
    Colorectal cancer TP53; BAX; PIK3R1; TGFB1; PIK3CA; RHOA; PIK3CB; PIK3R3; PIK3CG; RAC2
    Pancreatic cancer RALBP1; MAPK9; STAT3; RAC1; CCND1; RELA; TP53; PIK3R1; PLD1; NFKB1
    Chronic myeloid leukemia ARAF; IKBKB; HRAS; BRAF; HDAC2; TGFBR1; PIK3R3; PTPN11; SHC4; STAT5A

    TGFBR2 has several biochemical functions, for example, ATP binding, SMAD binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR2 itself. We selected most functions TGFBR2 had, and list some proteins which have the same functions with TGFBR2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding Aatk; ABCB1; KLHL8; MYH1E; NEK7; ERBB4; MARK2; SLC27A2; ROCK1; KATNAL2
    SMAD binding STUB1; TGFBR2; ACVR1; SKOR1; TGFBR3; COL1A2; PURA; EP300; BMP2; USP15
    glycosaminoglycan binding CCDC80; ENG; BGN; SPOCK3; SERPINE2; TGFBR3; TGFBR2; EGFLAM; SPOCK2; SERPINA5
    metal ion binding CPEB1B; DGKD; PPP2CA; ZNF200; PHC2A; PM20D1.2; AMPD1; STAMBPL1; ZNF292A; BA1
    protein binding MYZAP; FAM32A; FOXG1; SEMA7A; KRTAP5-9; FCHSD2; C11orf49; ATP6V1C1; PTGES2; ZBTB43
    receptor signaling protein serine/threonine kinase activity BMPR1BB; TGFBR1B; STK25B; BMPR1A; ACVR1; ACVR1B; ACVR1L; TGFBR1; ALPK2; BMPR2
    transforming growth factor beta binding LTBP1; ENG; ITGAV; TGFB3; CD109; ACVR1; TGFBR1; HYAL2; LTBP4; TGFBR3
    contributes_to transforming growth factor beta binding TGFBR3; ENG; TGFBR2; TGFBR1
    transforming growth factor beta receptor activity, type II AMHR2; TGFBR2
    transforming growth factor beta-activated receptor activity ACVRL1; TGFBR2; ENG; BMPR2A; TGFBR1; BMPR2B; TGFBR3; LTBP1
    transmembrane receptor protein serine/threonine kinase activity TGFBR2; ACVR1; ACVR2AA; BMPR1A; ALPK2; ACVR1B; TGFBR1B; BMPR2B; ACVR1L; BMPR1BB
    type I transforming growth factor beta receptor binding TGFB1; SMAD2; SNX25; TGFBR2; FKBP1A; SMAD7; TGFB3; ENG; SMAD6
    type III transforming growth factor beta receptor binding TGFB3; TGFB1; TGFBR2; TGFB2

    TGFBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR2.

    TGFB1; TGFB3; SCUBE3

    TGF

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