TGFBR2 Protein


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Official Full Name transforming growth factor, beta receptor II (70/80kDa)
Background This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Synonyms TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II beta; transforming growth factor, beta receptor II alpha; transforming growth factor, beta receptor II delta; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II epsilon;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • GST
    • His&Myc
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TGFBR2-151H Recombinant Human TGFBR2, Fc Chimera HEK293 Fc
    Human TGFBR2-152H Recombinant Human TGFBR2, Fc-His tagged Human Cell Fc/His
    Human TGFBR2-159H Recombinant Human TGFBR2 Protein, Fc tagged HEK293 Fc
    Human TGFBR2-1684H Recombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa) Mammalian cells N/A
    Human TGFBR2-229H Recombinant Human TGFBR2 protein, Fc-tagged HEK293 Fc
    Human TGFBR2-444H Recombinant Human TGFBR2, GST-tagged, Active Sf9 Insect Cell GST
    Human TGFBR2-646H Recombinant Human TGFBR2, Fc Chimera Mammalian cells Fc Chimera
    Human TGFBR2-697H Recombinant Human TGFBR2, Fc-tagged, Biotinylated Human Cell Fc
    Human TGFBR2-923H Recombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa) Human N/A
    Mouse Tgfbr2-1778M Recombinant Mouse Transforming Growth Factor, Beta Receptor II Mammalian cells N/A
    Mouse Tgfbr2-8188M Recombinant Mouse Tgfbr2 protein, His & T7-tagged E.coli His/T7
    Rat TGFBR2-6039R Recombinant Rat TGFBR2 Protein Mammalian Cell His
    Rat Tgfbr2-8722R Recombinant Rat Tgfbr2, Fc tagged Human Cell Fc
    Cynomolgus Monkey TGFBR2-8814C Recombinant Cynomolgus TGFBR2, Fc tagged Human Cell Fc
    Rhesus Macaque TGFBR2-4689R Recombinant Rhesus monkey TGFBR2 Protein, His-tagged Mammalian Cell His
    Chicken TGFBR2-6979C Recombinant Chicken TGFBR2 Mammalian Cell His
    Zebrafish TGFBR2-9644Z Recombinant Zebrafish TGFBR2 Mammalian Cell His
    Human TGFBR2-2842HCL Recombinant Human TGFBR2 cell lysate Human Cell N/A
    Rat TGFBR2-1374RCL Recombinant Rat TGFBR2 cell lysate Human Cell N/A
    Cynomolgus Monkey TGFBR2-1291CCL Recombinant Cynomolgus TGFBR2 cell lysate Human Cell N/A
    Mouse Tgfbr2-15M Recombinant Mouse Tgfbr2(Ile24-Asp184) Protein, C-Fc-tagged HEK293 Fc
    Rat Tgfbr2-2261R Recombinant Rat Tgfbr2 protein, His&Myc-tagged Insect Cell His&Myc
    Human TGFBR2-2765H Recombinant Human TGFBR2 Protein, His-tagged E.coli N-His
    Rat Tgfbr2-3573R Recombinant Rat Tgfbr2 protein, His&Myc-tagged E.coli His&Myc
    Human TGFBR2-173H Recombinant Human TGFBR2 protein, Fc-tagged HEK293 Fc
    Human TGFBR2-377H Recombinant Human TGFBR2 Protein (Met1-Gln166), His-tagged Insect Cell His
    Human TGFBR2-4439H Recombinant Human TGFBR2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TGFBR2-703H Recombinant Human TGFBR2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Tgfbr2-6393M Recombinant Mouse Tgfbr2 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    TGFBR2 involved in several pathways and played different roles in them. We selected most pathways TGFBR2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway GNA12; RRAS2; PPM1AA; RAP1A; MAP3K12; PPM1AB; MAPK8IP2; FGF1; RAC3A; CDC42L2
    Cytokine-cytokine receptor interaction CCL4L2; IL4; CCL28; CCL7; IL3RA; CXCL2; TNFRSF10C; IL22; CSF1; CCL20B
    FoxO signaling pathway GRB2A; G6PC3; SGK3; MAPK12A; TGFBR1; AGAP2; TGFBR1A; PRKAG1; GADD45BA; CDKN1BB
    Endocytosis PIP5K1C; SNX32; DNM2B; SH3GLB1A; SH3GLB2B; ZFYVE20; DNM2; ADRBK2; MVB12BB; ERBB3
    TGF-beta signaling pathway LFT2; TGFBR2; ID3; NBL1; CUL1A; SMAD3; INHBAB; AMH; NDR1; SMAD7B
    Osteoclast differentiation SOCS1; PIK3R5; TYROBP; PIK3R3; TREM2; TGFBR2; LILRA2; CYLD; PIK3CG; CSF1R
    Hippo signaling pathway TGFBR1; PPP2R2B; SAV1; SCRIB; FZD1; YWHAZ; NKD1; YWHAG; BTRC; SMAD7
    Adherens junction ACTN3B; ACTN3; FARP2; MAPK3; CTNNA3; NLK2; CDC42L; LEF1; PTPN1; PTPRJ
    Chagas disease (American trypanosomiasis) GNAQ; Il2; TGFBR2; CCL3; IFNGR2; GNAI3; CD247; FASLG; SERPINE1; PPP2R2B
    Pathways in cancer FGF1; PTGER4; LAMB2; WNT2; LAMA5; PLEKHG5; GNGT1; PRKCG; PIK3CA; RARB
    Transcriptional misregulation in cancer FOXO1; PPARG; MLF1; MEN1; SP1; HIST1H3G; RXRB; TAF15; KLF3; PTK2
    Colorectal cancer PIK3CG; TRP53; APC2; BIRC5; TP53; RAC2; MSH2; APPL1; CCND1; MAPK1
    Pancreatic cancer TGFB3; SMAD4; KRAS; RAF1; MAP2K1; BAD; CASP9; PLD1; RALB; SMAD3
    Chronic myeloid leukemia KRAS; ABL1; HRAS; ARAF; SHC3; SHC1; AKT2; BAD; STAT5A; PIK3R3

    TGFBR2 has several biochemical functions, for example, ATP binding, SMAD binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR2 itself. We selected most functions TGFBR2 had, and list some proteins which have the same functions with TGFBR2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ICK; MAPK8A; AARS2; CAMK2G1; DDX24; CLK2; P2RX4B; MAPK10; ABCA13; MAP2K3
    SMAD binding TGFBR3; RNF111; STUB1; MEF2A; USP15; PML; MAGI2; COL5A2; HMGA2; SKIL
    glycosaminoglycan binding DCN; TGFBR3; SPOCK2; ENG; EPYC; NDNF; VIT; SERPINE2; PODXL2; TGFBR2
    metal ion binding ZFP830; PRICKLE2A; ZNF644A; MT1HL1; RASA3; COL1A2; COL9A1; ZDHHC16B; NRXN2A; ZFP639
    protein binding CREB3L3; SIX1; PCGF6; PSMC1; NPAS2; SPOPL; HDHD2; AKT1S1; FKBP8; LINGO1B
    receptor signaling protein serine/threonine kinase activity ACVR1B; BMPR1BA; ALPK2; TGFBR1; PANK1A; NEK4; STK24A; AMHR2; BMPR1AA; ACVR2AA
    transforming growth factor beta binding CD109; LTBP1; TGFBR1; HYAL2; TGFBR2; VASN; ACVR1; ENG; ACVRL1; LTBP4
    contributes_to transforming growth factor beta binding TGFBR2; TGFBR3; ENG; TGFBR1
    transforming growth factor beta receptor activity, type II TGFBR2; AMHR2
    transforming growth factor beta-activated receptor activity BMPR2B; TGFBR3; BMPR2A; TGFBR1; TGFBR2; ACVRL1; LTBP1; ENG
    transmembrane receptor protein serine/threonine kinase activity BMPR1A; BMPR1B; BMPR2A; BMPR1AB; ACVR1L; BMPR2B; ACVR1BA; TGFBR1A; ALPK2; BMPR1AA
    type I transforming growth factor beta receptor binding SMAD7; TGFBR2; TGFB3; SNX25; SMAD6; TGFB1; FKBP1A; ENG; SMAD2
    type III transforming growth factor beta receptor binding TGFB1; TGFB2; TGFBR2; TGFB3

    TGFBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR2.



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