Active Recombinant Mouse Tgfbr2 Protein(Ile24-Asp159), hFc-tagged

• Cat.No.: Tgfbr2-6816M
• Product Overview: Active Recombinant Mouse Tgfbr2 Protein(Q62312-2)(Ile24-Asp159), fused with C-terminal hFc tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Mouse
• Tag: Fc
• Form: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Bio-activity: Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells.The ED50 for this effect is 69.07 ng/ml in the presence of 1ng/ml of recombinant human TGF-beta 1.
• Molecular Mass: 42.3 KDa
• Protein length: Ile24-Asp159
• Endotoxin: Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Storage: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
  Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
  Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
• Reconstitution: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
  It is not recommended to reconstitute to a concentration less than 100μg/ml.
  Dissolve the lyophilized protein in distilled water.
  Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Gene Information

• Gene Name: Tgfbr2 transforming growth factor, beta receptor II [ Mus musculus ]
• Official Symbol: Tgfbr2
• Synonyms: TGFBR2; transforming growth factor, beta receptor II; TGF-beta receptor type-2; TGFR-2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta type II receptor; transforming growth factor-beta receptor type II; DNIIR; RIIDN; TBR-II; AU042018; TbetaRII; TbetaR-II; 1110020H15Rik
• Gene ID: 21813
• mRNA Refseq: NM_009371
• Protein Refseq: NP_033397

Reviews

04/14/2023

TGFBR2 protein's remarkable performance in ELISA and protein electron microscopy structure analysis positions it as a valuable tool in various fields, including cardiovascular research, developmental biology, and molecular medicine.

12/13/2022

TGFBR2 protein's utility extends to protein electron microscopy structure analysis, where it plays a crucial role in investigating the detailed architecture and conformational changes of proteins.

06/25/2021

TGFBR2 protein is highly recommended for use in various research applications, including ELISA and protein electron microscopy structure analysis.

Q&As

How is TGFBR2 linked to autoimmune diseases?

Dysregulation of TGF-beta signaling, including TGFBR2, has been associated with autoimmune diseases. Understanding these pathways may provide insights into developing targeted therapies.

Are there clinical trials targeting TGFBR2?

Yes, there are ongoing clinical trials exploring the modulation of TGFBR2 for various conditions, including cancer and fibrotic diseases.

How does TGFBR2 affect cardiovascular health?

TGFBR2 is involved in cardiovascular development and homeostasis. Dysregulation can contribute to conditions like aortic aneurysms and other cardiovascular diseases.

Is TGFBR2 involved in neurological disorders?

Some studies suggest a potential link between TGFBR2 and neurological disorders. Further research is ongoing to understand its role in conditions like Alzheimer's and Parkinson's disease.

Can TGFBR2 be a therapeutic target for fibrotic diseases?

Yes, TGFBR2 is implicated in fibrosis, and targeting it may offer therapeutic options for diseases characterized by excessive tissue scarring.