Recombinant Human TNFRSF12A Protein, Flag-tagged

• Cat.No.: TNFRSF12A-2125H
• Product Overview: The TWEAK Human Recombinant is manufactured with N-terminal fusion of 13 amino acid FLAG Tag. The TNFSF12 Flag -Tagged Fusion Protein has a Mw of 18.7kDa containing a total of 169 amino acid residues.

Specification

• Cat. No.: TNFRSF12A-2125H
• Description: TNFSF12 is a cytokine that is part of the TNF ligand family. TNFSF12 is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TNFSF12 induces apoptosis through multiple pathways of cell death in a cell type-specific manner. TNFSF12 promotes proliferation and migration of endothelial cells, and therefore acts as a regulator of angiogenesis. TNFSF12 is expressed in adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK h induces NFkB and chemokine secretion. TNFSF12 exerts an apoptotic activity in HT-29 human adenocarcinoma cells whilst cultured in the presence of IFN-α. TNFSF12 promotes proliferation and migration of endothelial cells.
• Source: HEK 293 cells.
• Purity: ≥90% (SDS-PAGE).
• Formulation: Filtered and lyophilized from 0.5mg/ml in 20mM Tris buffer and 50mM NaCl pH-7.5.
• Solubility: Add pyrogen free water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
• Amino Acid Sequence: HVDYKDDDDK PAGSAPKGRK TRARRAIAAH YEVHPRPGQD GAQAGVDGTV SGWEEARINS SSPLRYNRQI GEFIVTRAGL YYLYCQVHFD EGKAVYLKLD LLVDGVLALR CLEEFSATAA SSLGPQLRLC QVSGLLALRP GSSLRIRTLP WAHLKAAPFL TYFGLFQVH.
• Applications: Western blotting.
• Stability: Stable for at least six months after receipt when stored at -20°C.

Gene Information

• Gene Name: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A [ Homo sapiens ]
• Synonyms: TNFRSF12A; tumor necrosis factor receptor superfamily, member 12; FN14; CD266; TWEAKR; type I transmembrane protein Fn14; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14
• Gene ID: 51330
• mRNA Refseq: NM_016639
• Protein Refseq: NP_057723
• MIM: 605914
• UniProt ID: Q9NP84
• Chromosome Location: 16p13.3
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor activity

Reviews

11/26/2020

The manufacturer's commitment to delivering excellent technical support further enhances the experience, offering timely resolutions to any challenges I may encounter.

09/08/2019

the TNFRSF12A protein surpasses expectations in terms of quality, meeting the rigorous demands of my experiments.

06/16/2019

With the TNFRSF12A protein and the manufacturer's support, I can confidently pursue my research goals and achieve meaningful outcomes.

Q&As

Can TNFRSF12A be a potential therapeutic target for cardiovascular diseases?

Some studies suggest that TNFRSF12A may play a role in cardiovascular diseases, and targeting it could be a potential therapeutic strategy, but more research is needed.

Can TNFRSF12A be used as a diagnostic marker for certain diseases?

Research indicates that elevated levels of TNFRSF12A may serve as a diagnostic marker for certain cancers, providing valuable information for disease detection.

Are there any FDA-approved drugs targeting TNFRSF12A?

As of now, there are no FDA-approved drugs specifically targeting TNFRSF12A. However, research is ongoing to develop targeted therapies.

How is TNFRSF12A involved in inflammation?

TNFRSF12A is known to modulate inflammatory responses, and dysregulation of its signaling pathways may contribute to chronic inflammatory conditions.

Can TNFRSF12A be targeted for immunotherapy in cancer treatment?

TNFRSF12A is being explored as a potential target for immunotherapy in cancer, with studies investigating its role in modulating the immune response.