Recombinant Mouse CA12 Protein (Ala25-Ser301), C-His tagged
Cat.No. : | CA12-5491M |
Product Overview : | Recombinant mouse CA12 (Ala25-Ser301) fused with the C-terminal His tag was expressed in mammalian cells. |
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Description : | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10 % of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. |
Source : | Mammalian cells |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 30.47 kDa |
Protein Length : | Ala25-Ser301 |
Purity : | > 90 % as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS or lyophilized from PBS. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | CA12 carbonic anhydrase 12 [ Homo sapiens (human) ] |
Official Symbol : | CA12 |
Synonyms : | CA12; carbonic anhydrase 12; CAXII; CA-XII; T18816; HsT18816; carbonic anhydrase 12; carbonate dehydratase XII; carbonic anhydrase XII; carbonic dehydratase; tumor antigen HOM-RCC-3.1.3; EC 4.2.1.1 |
Gene ID : | 771 |
mRNA Refseq : | NM_001218 |
Protein Refseq : | NP_001209 |
MIM : | 603263 |
UniProt ID : | O43570 |
Products Types
◆ Recombinant Protein | ||
CA12-0233H | Recombinant Human CA12 Protein, GST-Tagged | +Inquiry |
CA12-1154M | Recombinant Mouse CA12 Protein, His (Fc)-Avi-tagged | +Inquiry |
Car12-1958M | Recombinant Mouse Car12 Protein, Myc/DDK-tagged | +Inquiry |
CA12-1455H | Recombinant Human CA12 protein, His-tagged | +Inquiry |
CA12-423R | Recombinant Rhesus Macaque CA12 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CA12-3067MCL | Recombinant Mouse CA12 cell lysate | +Inquiry |
CA12-3061HCL | Recombinant Human CA12 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewProfessional assistance, invaluable for complex protein experiments.
Cost-effective quantitation, ideal for budget-conscious labs.
Impressive expertise, accelerates our research progress.
Q&As (7)
Ask a questionKnown inhibitors can be identified through drug screening assays, and their impact on CA12 can be studied using kinetic studies and cell-based assays.
Cellular localization can be identified using immunofluorescence, subcellular fractionation, or electron microscopy.
CA12 has been implicated in tumor progression, particularly in hypoxic environments, by modulating pH and thus influencing tumor cell survival and metastasis. This can be assessed using cellular assays and tumor models.
Downstream pathways can be identified using pathway analysis tools, phosphoproteomics, and specific signal transduction assays.
The activity modulation under different pH conditions can be determined using enzymatic assays and pH shift experiments.
Expression changes in response to stressors can be analyzed using techniques like qPCR, Western blotting, or proteomics following cellular treatment with specific agents.
Genetic variants and their impact can be determined using structural models and functional assays comparing wild-type and mutant proteins.
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