Recombinant Mouse CD86 Antigen
Cat.No. : | Cd86-1706M |
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Cat. No. : | Cd86-1706M |
Description : | B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon γ. B7-1 and B7-2 are both members of the immunoglobulin superfamily. Human B7-2 and B7-1 share 26% amino acid identity. Human and mouse B7-2 share 50% amino acid identity. However, it has been observed that both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites. |
Molecular Weight : | The predicted molecular weight of Recombinant Mouse B7-2 is Mr 51.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60-65 kDa. |
Source : | Sf 21 Insect Cells. |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Tag : | Non |
Gene Name : | Cd86 CD86 antigen [ Mus musculus ] |
Synonyms : | Cd86; CD86 antigen; B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2; OTTMUSP00000015940; activation B7-2 antigen; T-lymphocyte activation antigen CD86; early T cell costimulatory molecule-1 |
Gene ID : | 12524 |
mRNA Refseq : | NM_019388 |
Protein Refseq : | NP_062261 |
UniProt ID : | P42082 |
Chromosome Location : | 16 26.9 cM |
Pathway : | Allograft rejection; Autoimmune thyroid disease; Cell adhesion molecules (CAMs); Graft-versus-host disease; Systemic lupus erythematosus; Toll-like receptor signaling pathway; Type I diabetes mellitus |
Function : | receptor activity |
Products Types
◆ Recombinant Protein | ||
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CD86-595H | Recombinant Human CD86 Protein, Fc-tagged | +Inquiry |
CD86-592C | Recombinant Cynomolgus monkey CD86 Protein | +Inquiry |
CD86-1289C | Recombinant Cynomolgus/Rhesus CD86 protein(Met1-His239), hFc-tagged | +Inquiry |
◆ Lysates | ||
CD86-1013CCL | Recombinant Cynomolgus CD86 cell lysate | +Inquiry |
CD86-2598MCL | Recombinant Mouse CD86 cell lysate | +Inquiry |
CD86-1971RCL | Recombinant Rat CD86 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewWith the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.
Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.
The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.
Q&As (5)
Ask a questionYes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.
In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.
CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.
There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.
CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.
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