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Recombinant Mouse CRBN Protein (1-445 aa), His-Myc-tagged

Cat.No. : CRBN-2109M
Product Overview : Recombinant Mouse CRBN Protein (1-445 aa) is produced by Yeast expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Neuroscience. Protein Description: Full Length.
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  • Gene Information
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Description : Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
Source : Yeast
Species : Mouse
Tag : His-Myc
Form : Tris-based buffer,50% glycerol
Molecular Mass : 54.9 kDa
Protein length : 1-445 aa
AA Sequence : MAGEGDQQDAAHNMGNHLPLLPADS EDEDDEIEMEVEDQDSKEARKPNII NFDTSLPTSHTYLGADMEEFHGRTL HDDDSCQVIPVLPEVLMILIPGQTL PLQLSHPQEVSMVRNLIQKDRTFAV LAYSNVQEREAQFGTTAEIYAYREE QEFGIEVVKVKAIGRQRFKVLELRT QSDGIQQAKVQILPECVLPSTMSAV QLESLNKCQVFPSKPISWEDQYSCK WWQKYQKRKFHCANLTSWPRWLYSL YDAETLMDRIKKQLREWDENLKDDS LPENPIDFSYRVAACLPIDDVLRIQ LLKIGSAIQRLRCELDIMNKCTSLC CKQCQETEITTKNEIFSLSLCGPMA AYVNPHGYVHETLTVYKASNLNLIG RPSTVHSWFPGYAWTIAQCKICASH IGWKFTATKKDMSPQKFWGLTRSAL LPTIPETEDEISPDKVILCL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : Crbn cereblon [ Mus musculus ]
Official Symbol : CRBN
Synonyms : CRBN; cereblon; protein cereblon; protein PiL; novel lethal; piL; AF229032; AW108261; 2610203G15Rik; 2900045O07Rik;
Gene ID : 58799
mRNA Refseq : NM_021449
Protein Refseq : NP_067424
UniProt ID : Q8C7D2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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