Recombinant Human CRBN Protein, 81-319, C-His-Avi-tagged, Biotinylated

• Cat.No.: CRBN-657H
• Product Overview: Biotinylated recombinant Human CRBN Protein (81-319) with C-His-Avi-tag was expressed in HEK293.

Specification

• Description: This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: C-His-Avi
• Molecular Mass: 30 kDa
• Protein Length: 81-319
• AA Sequence: IPVLPQVMMILIPGQTLPLQLFHPQ EVSMVRNLIQKDRTFAVLAYSNVQE REAQFGTTAEIYAYREEQDFGIEIV KVKAIGRQRFKVLELRTQSDGIQQA KVQILPECVLPSTMSAVQLESLNKC QIFPSKPVSREDQCSYKWWQKYQKR KFHCANLTSWPRWLYSLYDAETLMD RIKKQLREWDENLKDDSLPSNPIDF SYRVAACLPIDDVLRIQLLKIGSAI QRLRCELDIMNKCTHHHHHHGLNDI FEAQKIEWHE
• Endotoxin: < 1 EU/μg by LAL
• Purity: > 85 % by SDS-PAGE
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.51 mg/mL by BCA
• Storage Buffer: Lyophilized from sterile PBS, pH6.5

Gene Information

• Gene Name: CRBN cereblon [ Homo sapiens (human) ]
• Official Symbol: CRBN
• Synonyms: CRBN; cereblon; mental retardation, non syndromic, autosomal recessive, 2A , MRT2A; protein cereblon; protein x 0001; MRT2; MRT2A; MGC27358; DKFZp781K0715
• Gene ID: 51185
• mRNA Refseq: NM_001173482
• Protein Refseq: NP_001166953
• MIM: 609262
• UniProt ID: Q96SW2