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Active Recombinant Mouse Dhh protein

Cat.No. : Dhh-384M
Product Overview : Recombinant Mouse Dhh was expressed in E. coli.
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  • Gene Information
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Description : Desert hedgehog protein (DHH) is a member of the Hedgehog family which encodes signaling molecules that play an important role in regulating morphogenesis. It is predicted to be made as a precursor that is auto-catalytically cleaved; the N-terminal portion is soluble and contains the signaling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. DHH may be involved in both male gonadal differentiation and perineurial development. DHH binds both Patched and Patched 2 as well as Hedgehog interacting protein (Hip). It induces steroidogenicfactor 1(SF1), which is instrumental in promoting Leydig cell differentiation. It also promotes the deposition of basal lamina surrounding seminiferous tubules.
Source : E. coli
Species : Mouse
Form : Lyophilized after extensive dialysis against PBS.
Bio-activity : ED50 <20 μg/ml, measured by its ability to induce alkaline phosphatase production by CCL-226 cells.
Molecular Mass : 20.1 kDa, observed by reducing SDS-PAGE.
Protein length : 176 amino acids
AA Sequence : IIGPGRGPVG RRRYVRKQLV PLLYKQFVPS MPERTLGASGPAEGRVTRGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTERCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH
YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNHIHVSVKADNS LAVRAGG
Endotoxin : < 0.2 EU/μg, determined by LAL method.
Purity : > 98% as analyzed by SDS-PAGE and HPLC.
Storage : Lyophilized recombinant Mouse Desert Hedgehog (DHH) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Mouse Desert Hedgehog (DHH) should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
Reconstitution : Reconstituted in ddH2O or PBS at 100 μg/ml.
Gene Name : Dhh desert hedgehog [ Mus musculus ]
Official Symbol : Dhh
Synonyms : DHH; desert hedgehog; desert hedgehog protein; HHG-3; C78960; MGC73610;
Gene ID : 13363
mRNA Refseq : NM_007857
Protein Refseq : NP_031883
UniProt ID : Q61488

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does DHH protein deficiency affect reproductive development? 09/30/2022

There is no conclusive evidence that DHH protein deficiency affects the development of the reproductive system, but research suggests that it may be involved in the development of the male reproductive system.

What is the function of DHH protein in the cardiovascular system? 04/27/2022

The function of DHH protein in the cardiovascular system is unknown, but studies suggest that it may be involved in the differentiation and maturation process of cardiomyocytes.

How is DHH protein related to autism? 02/13/2022

Studies have shown that DHH protein may be involved in the development of autism, but the specific mechanism is not clear.

What is the function of DHH protein in the nervous system? 01/31/2021

The function of DHH protein in the nervous system is mainly to promote the differentiation and maturation of neurons, as well as the formation of synapses and the conduction of nerve signals.

Does DHH protein deficiency affect mental development? 09/28/2020

DHH protein deficiency may affect mental development, but the exact extent of the effect needs further research.

How is DHH protein related to arthritis? 06/17/2020

Studies have shown that DHH protein may play an important role in the pathogenesis of arthritis, but its specific role needs to be further studied.

Customer Reviews (3)

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Reviews
08/26/2022

    DHH has good stability under different environmental conditions

    07/18/2021

      DHH plays a significant role in signal transduction pathways.

      04/28/2021

        DHH has good absorbability and high bioavailability.

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