Recombinant Mouse Gdf15 Protein, His-tagged
Cat.No. : | Gdf15-7379M |
Product Overview : | Recombinant mouse GDF15 fused to His-tag at N-terminus, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Liquid |
Molecular Mass : | 14.9 kDa |
Protein length : | 189-303 |
AA Sequence : | MGSSHHHHHHSSGLVPRGSHMGSSA HAHPRDSCPLGPGRCCHLETVQATL EDLGWSDWVLSPRQLQLSMCVGECP HLYRSANTHAQIKARLHGLQPDKVP APCCVPSSYTPVVLMHRTDSGVSLQ TYDDLVARGCHCA |
Purity : | > 90 % by SDS-PAGE |
Stability : | Shelf life: one year from despatch. |
Storage : | Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing. |
Concentration : | 1.0 mg/mL (determined by Bradford assay) |
Storage Buffer : | 20 mM Phosphate buffer (pH 8.0) containing 10 % glycerol. |
Gene Name : | Gdf15 growth differentiation factor 15 [ Mus musculus (house mouse) ] |
Official Symbol : | Gdf15 |
Synonyms : | Gdf15; growth differentiation factor 15; NAG; SBF; MIC-; MIC-1; NAG-1; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1 |
Gene ID : | 23886 |
mRNA Refseq : | NM_001330687 |
Protein Refseq : | NP_001317616 |
UniProt ID : | Q9Z0J7 |
Products Types
◆ Recombinant Protein | ||
GDF15-2158R | Recombinant Rat GDF15 Protein, His (Fc)-Avi-tagged | +Inquiry |
GDF15-20H | Recombinant Human GDF15 protein(Ala197-Ile308), His-tagged | +Inquiry |
GDF15-105H | Recombinant Human GDF15 Protein | +Inquiry |
GDF15-106H | Recombinant Human GDF15 Protein | +Inquiry |
GDF15-047H | Recombinant Human GDF15 Protein | +Inquiry |
◆ Native Protein | ||
GDF15-27680TH | Active Native Human GDF15 Protein | +Inquiry |
◆ Lysates | ||
GDF15-2705HCL | Recombinant Human GDF15 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionGDF15 influences cardiovascular health, impacting heart failure progression and atherosclerotic processes.
GDF15 modulates inflammatory and immune responses, crucial in the context of chronic diseases.
GDF15 contributes to tissue repair and fibrosis, particularly in liver and kidney pathologies.
GDF15 affects cancer development by altering the tumor microenvironment and influencing tumor cell behavior.
Changes in GDF15 expression are linked to aging and age-related diseases, affecting various physiological processes.
GDF15 is involved in regulating energy metabolism and appetite, playing a key role in obesity and metabolic syndromes.
GDF15 is involved in cellular stress responses, influencing apoptosis and cell survival mechanisms.
Customer Reviews (3)
Write a reviewDependable protein purification, consistent and cost-effective.
Precise mass spectrometry analysis, key for proteomics research.
Great antibody validation, enhances our immunoprecipitation experiments.
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