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Recombinant Mouse Gdf15 Protein, His-tagged

Cat.No. : Gdf15-7379M
Product Overview : Recombinant mouse GDF15 fused to His-tag at N-terminus, was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. Mice lacking a functional copy of this gene exhibit progressive loss of motor neurons, and more rapid blood clot formation.
Source : E. coli
Species : Mouse
Tag : His
Form : Liquid
Molecular Mass : 14.9 kDa
Protein length : 189-303
AA Sequence : MGSSHHHHHHSSGLVPRGSHMGSSA HAHPRDSCPLGPGRCCHLETVQATL EDLGWSDWVLSPRQLQLSMCVGECP HLYRSANTHAQIKARLHGLQPDKVP APCCVPSSYTPVVLMHRTDSGVSLQ TYDDLVARGCHCA
Purity : > 90 % by SDS-PAGE
Stability : Shelf life: one year from despatch.
Storage : Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing.
Concentration : 1.0 mg/mL (determined by Bradford assay)
Storage Buffer : 20 mM Phosphate buffer (pH 8.0) containing 10 % glycerol.
Gene Name : Gdf15 growth differentiation factor 15 [ Mus musculus (house mouse) ]
Official Symbol : Gdf15
Synonyms : Gdf15; growth differentiation factor 15; NAG; SBF; MIC-; MIC-1; NAG-1; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1
Gene ID : 23886
mRNA Refseq : NM_001330687
Protein Refseq : NP_001317616
UniProt ID : Q9Z0J7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does GDF15 play in cardiovascular diseases, particularly in heart failure and atherosclerosis? 08/14/2022

GDF15 influences cardiovascular health, impacting heart failure progression and atherosclerotic processes.

How does GDF15 influence inflammatory processes and immune responses in chronic diseases? 07/17/2022

GDF15 modulates inflammatory and immune responses, crucial in the context of chronic diseases.

How does GDF15 contribute to tissue repair and fibrosis in organs like the liver and kidneys? 10/16/2021

GDF15 contributes to tissue repair and fibrosis, particularly in liver and kidney pathologies.

What is the impact of GDF15 on cancer development and progression, especially in terms of tumor microenvironment modulation? 05/18/2021

GDF15 affects cancer development by altering the tumor microenvironment and influencing tumor cell behavior.

How do alterations in GDF15 expression impact aging and age-related pathologies? 07/14/2018

Changes in GDF15 expression are linked to aging and age-related diseases, affecting various physiological processes.

How does GDF15 regulate energy metabolism and appetite in the context of obesity and metabolic disorders? 04/21/2018

GDF15 is involved in regulating energy metabolism and appetite, playing a key role in obesity and metabolic syndromes.

What are the mechanisms by which GDF15 affects cellular stress responses and apoptosis? 03/05/2018

GDF15 is involved in cellular stress responses, influencing apoptosis and cell survival mechanisms.

Customer Reviews (3)

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Reviews
03/19/2021

    Dependable protein purification, consistent and cost-effective.

    07/29/2019

      Precise mass spectrometry analysis, key for proteomics research.

      02/22/2019

        Great antibody validation, enhances our immunoprecipitation experiments.

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