Recombinant Rat EFNA1 Protein (18-182 aa), GST-tagged

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Recombinant Rat EFNA1 Protein (18-182 aa), GST-tagged

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Cat.No. : EFNA1-469R
Product Overview : Recombinant Rat EFNA1 Protein (18-182 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Protein Description: Full Length of Mature Protein.
Description : Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Source : E. coli
Species : Rat
Tag : GST
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 46.4 kDa
Protein length : 18-182 aa
AA Sequence : ADRHIVFWNS SNPKFREEDY TVHVQLNDYL DIICPHYEDD SVADAAMERY TLYMVEHQEY VTCEPQSKDQ VRWKCNQPSA KHGPEKLSEK FQRFTPFTLG KEFKEGHSYY YISKPIYHQE TQCLKLKVTV NGKITHSPHA HANPQEKRLQ ADDPEVQVLH SIGHS
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : Efna1 ephrin A1 [ Rattus norvegicus ]
Official Symbol : EFNA1
Synonyms : EFNA1; ephrin A1; ephrin-A1; LERK-1; B61;
Gene ID : 94268
mRNA Refseq : NM_053599
Protein Refseq : NP_446051
UniProt ID : P97553

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