Recombinant Rat EFNA1 Protein (18-182 aa), GST-tagged
Cat.No. : | EFNA1-469R |
Product Overview : | Recombinant Rat EFNA1 Protein (18-182 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Protein Description: Full Length of Mature Protein. |
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Description : | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis. |
Source : | E. coli |
Species : | Rat |
Tag : | GST |
Form : | Tris-based buffer, 50% glycerol |
Molecular Mass : | 46.4 kDa |
Protein length : | 18-182 aa |
AA Sequence : | ADRHIVFWNSSNPKFREEDYTVHVQ LNDYLDIICPHYEDDSVADAAMERY TLYMVEHQEYVTCEPQSKDQVRWKC NQPSAKHGPEKLSEKFQRFTPFTLG KEFKEGHSYYYISKPIYHQETQCLK LKVTVNGKITHSPHAHANPQEKRLQ ADDPEVQVLHSIGHS |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with concentration instruction is sent along with the products. |
Gene Name : | Efna1 ephrin A1 [ Rattus norvegicus ] |
Official Symbol : | EFNA1 |
Synonyms : | EFNA1; ephrin A1; ephrin-A1; LERK-1; B61; |
Gene ID : | 94268 |
mRNA Refseq : | NM_053599 |
Protein Refseq : | NP_446051 |
UniProt ID : | P97553 |
Products Types
◆ Recombinant Protein | ||
EFNA1-1386H | Recombinant Human EFNA1 Protein, MYC/DDK-tagged | +Inquiry |
Efna1-3264M | Active Recombinant Mouse Efna1 protein(Met1-Ser182), hFc-tagged | +Inquiry |
EFNA1-229H | Recombinant Human EFNA1 Protein, Fc-tagged | +Inquiry |
EFNA1-1681R | Recombinant Rat EFNA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Efna1-159M | Recombinant Mouse Efna1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
EFNA1-2177MCL | Recombinant Mouse EFNA1 cell lysate | +Inquiry |
EFNA1-1514RCL | Recombinant Rat EFNA1 cell lysate | +Inquiry |
EFNA1-2594HCL | Recombinant Human EFNA1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, EFNA1 is being investigated as a potential therapeutic target in cancer treatment, aiming to develop drugs that modulate its activity.
Researchers are exploring the use of EFNA1 as a biomarker for cancer detection, with studies suggesting its potential as a diagnostic tool.
EFNA1 binds to Eph receptors, initiating cell signaling pathways that regulate various cellular processes, making this interaction crucial for normal physiological functions.
EFNA1 is implicated in cancer progression, influencing cell migration and invasion. Understanding its role can potentially lead to targeted therapies for certain cancers.
Dysregulation of EFNA1 has been linked to certain neurological disorders, including Alzheimer's disease and neurodevelopmental disorders.
Customer Reviews (3)
Write a reviewTheir prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.
Its purity, stability, and consistency are unparalleled, ensuring reliable and reproducible results in my research.
This protein has proven to be an invaluable asset in my experiments, enabling accurate and precise measurements with exceptional sensitivity.
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