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Recombinant Rat EFNA1 Protein (18-182 aa), GST-tagged

Cat.No. : EFNA1-469R
Product Overview : Recombinant Rat EFNA1 Protein (18-182 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Protein Description: Full Length of Mature Protein.
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Description : Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Source : E. coli
Species : Rat
Tag : GST
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 46.4 kDa
Protein length : 18-182 aa
AA Sequence : ADRHIVFWNSSNPKFREEDYTVHVQ LNDYLDIICPHYEDDSVADAAMERY TLYMVEHQEYVTCEPQSKDQVRWKC NQPSAKHGPEKLSEKFQRFTPFTLG KEFKEGHSYYYISKPIYHQETQCLK LKVTVNGKITHSPHAHANPQEKRLQ ADDPEVQVLHSIGHS
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : Efna1 ephrin A1 [ Rattus norvegicus ]
Official Symbol : EFNA1
Synonyms : EFNA1; ephrin A1; ephrin-A1; LERK-1; B61;
Gene ID : 94268
mRNA Refseq : NM_053599
Protein Refseq : NP_446051
UniProt ID : P97553

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can EFNA1 be a target for therapeutic interventions in cancer treatment? 05/06/2021

Yes, EFNA1 is being investigated as a potential therapeutic target in cancer treatment, aiming to develop drugs that modulate its activity.

Are there diagnostic applications for EFNA1 in cancer detection? 01/15/2021

Researchers are exploring the use of EFNA1 as a biomarker for cancer detection, with studies suggesting its potential as a diagnostic tool.

How does EFNA1 interact with the Eph receptors, and what is the significance of this interaction? 04/16/2019

EFNA1 binds to Eph receptors, initiating cell signaling pathways that regulate various cellular processes, making this interaction crucial for normal physiological functions.

How does EFNA1 impact cancer research and treatment? 02/02/2018

EFNA1 is implicated in cancer progression, influencing cell migration and invasion. Understanding its role can potentially lead to targeted therapies for certain cancers.

Are there any neurological disorders associated with EFNA1 dysregulation? 10/26/2016

Dysregulation of EFNA1 has been linked to certain neurological disorders, including Alzheimer's disease and neurodevelopmental disorders.

Customer Reviews (3)

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Reviews
08/15/2019

    Their prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.

    04/04/2019

      Its purity, stability, and consistency are unparalleled, ensuring reliable and reproducible results in my research.

      11/22/2016

        This protein has proven to be an invaluable asset in my experiments, enabling accurate and precise measurements with exceptional sensitivity.

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