Efna1
-
Official Full Name
ephrin-A1
-
Overview
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system -
Synonyms
EFNA1; ephrin-A1; EPLG1, TNFAIP4; ECKLG; LERK1; TNF alpha-induced protein 4; ligand of eph-related kinase 1; immediate early response protein B61; eph-related receptor tyrosine kinase ligand 1; tumor necrosis factor alpha-induced protein 4; tumor necrosis; B61; EFL1; EPLG1; LERK-1; TNFAIP4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Fc
- GST
- His
- Avi
- SUMO
- Myc
- DDK
- Non
- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
What is EFNA1 protein?
EFNA1 (ephrin A1) gene is a protein coding gene which situated on the long arm of chromosome 1 at locus 1q22. This gene encodes a member of the ephrin (EPH) family called EFNA1, also known as Ephrin A1 (EphA1), a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage. Human Ephrin A1 binds to the receptor tyrosine kinase EphA2, EphA4, EphA5, EphA6 and EphA7. Also binds with low affinity to EphA1. The EFNA1 protein is consisted of 205 amino acids and its molecular mass is approximately 23.8 kDa.
What is the function of EFNA1 protein?
Ephrin-A1 plays an important role in the development of ephrin-A1, regulating axonal guidance, synaptic formation and nerve cell migration. In adult tissues, Ephrin-A1 also plays a key role in processes such as nervous system maintenance and repair, angiogenesis, immune system and cancer development. In addition, Ephrin-A1 can also interact with other signaling pathways and influence cellular behavior. For example, interactions with the Wnt signaling pathway can influence cell fate decisions and embryonic development. Interaction with the TGF-β signaling pathway can regulate cell migration and epithelial mesenchymal transformation.
Fig1. (D) EPHA2/ephrin-A1 induce tumor growth. (Stavros P Papadakos, 2023)
EFNA1 Related Signaling Pathway
After binding to Eph receptor, Ephrin-A1 could trigger downstream signal transduction pathways including MAPK, PI3K/AKT and Rho family GTPase signaling pathways, which were involved in multiple biological processes such as cell proliferation, migration, adhesion, differentiation and apoptosis. When Ephrin-A1 protein activated EphA receptor, tyrosine kinase activity in EphrA receptor was inhibited, mediating the change of cell attachment and growth anchoring.
EFNA1 Related Diseases
Several studies have suggested that abnormal expression of Ephrin-A1 is associated with the development and metastasis of tumors like breast cancer and gastric cancer. In addition, Ephrin-A1 has been found to play an important role in neurological diseases like glioblastoma, cardiovascular diseases and inflammatory diseases.
Bioapplications of EFNA1
Ephrin-A1 plays an important role in tumorigenesis and development, and several antibodies and small molecule inhibitors targeting Eph receptors are currently in preclinical or clinical trials.
High Purity
Fig1. SDS-PAGE (EFNA1-3096H) (PROTOCOL for western blot)
.
Fig2. SDS-PAGE (EFNA1-1561H) (PROTOCOL for western blot)
Case Study 1: Pitna Kim, 2019
Fig1. PI-PLC sensitivity of membrane-associated GPI-APs in schizophrenia.
Case Study 2: Yi Wang, 2016
Fig2. Boyden chamber staining of EPCs' chemotaxis to HCC cells with different EphA1 levels, Asterisks indicate significant differences (**P < 0.01, ***P < 0.001) with respect to the corresponding control.
Efna1 involved in several pathways and played different roles in them. We selected most pathways Efna1 participated on our site, such as Arf6 signaling events, Axon guidance, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efna1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arf6 signaling events | ADAP1;EPHA2;ADRB2;FBXO8;EGF;KIF13B;ARAP2;EFNA1;IPCEF1 |
| Axon guidance | GSK3B;COL9A1;SPNA2;PAK7;NTN4;ACTR2B;GNAI2;DPYSL5A;DUSP7 |
| Developmental Biology | KCNQ2;SPAG9;DPYSL5A;EFNA3B;ACTR2;DPYSL5B;DLG3;RGMA;EPHB3A |
| EPH-Ephrin signaling | ITSN1;EPHB4B;ACTR2B;EFNB2A;ARPC2;EPHA4A;ARPC3;CLTC;CLTB |
| EPH-ephrin mediated repulsion of cells | EFNA1B;AP2S1;EFNA2A;EFNB3;EFNB2;EPHA2;EFNB1;EPHB4A;CLTB |
| EPHA forward signaling | EFNA1;ARHGEF15;EFNA3;EPHA2;EFNA5;BLK;CRKL;EFNA2 |
| EPHA-mediated growth cone collapse | KDR;EPHA2;EFNA5;EFNA1B;EFNA1;EPHA4A;SHB;MYL12B;EFNA3B |
| EPHA2 forward signaling |
Efna1 has several biochemical functions, for example, ephrin receptor binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Efna1 itself. We selected most functions Efna1 had, and list some proteins which have the same functions with Efna1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ephrin receptor binding | EFNA2;CHN1;SHC1;EFNB2A;PTPN1;EFNA5;EFNA1B;ANKS1B;EFNA4 |
| protein binding | SMARCA2;TRIM74;KREMEN1;YWHAG;RC3H2;MAP2;APAF1;SETD7;MSX2 |
| receptor binding | EDN3;SRPX2;IZUMO1;HCST;CADM1A;KNG1;WNT7A;DHRS4;CD276 |
Efna1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efna1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efna1.
EPHA2; PPBP; XRCC6; EEF1G; SUMO2; KAT5
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewTheir prompt assistance and willingness to go above and beyond to ensure my success have been immensely valuable.
Its purity, stability, and consistency are unparalleled, ensuring reliable and reproducible results in my research.
This protein has proven to be an invaluable asset in my experiments, enabling accurate and precise measurements with exceptional sensitivity.
Q&As (5)
Ask a questionYes, EFNA1 is being investigated as a potential therapeutic target in cancer treatment, aiming to develop drugs that modulate its activity.
Researchers are exploring the use of EFNA1 as a biomarker for cancer detection, with studies suggesting its potential as a diagnostic tool.
EFNA1 binds to Eph receptors, initiating cell signaling pathways that regulate various cellular processes, making this interaction crucial for normal physiological functions.
EFNA1 is implicated in cancer progression, influencing cell migration and invasion. Understanding its role can potentially lead to targeted therapies for certain cancers.
Dysregulation of EFNA1 has been linked to certain neurological disorders, including Alzheimer's disease and neurodevelopmental disorders.
Ask a Question for All Efna1 Products
Required fields are marked with *
My Review for All Efna1 Products
Required fields are marked with *
