This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system
Synonyms
EFNA1; ephrin-A1; EPLG1, TNFAIP4; ECKLG; LERK1; TNF alpha-induced protein 4; ligand of eph-related kinase 1; immediate early response protein B61; eph-related receptor tyrosine kinase ligand 1; tumor necrosis factor alpha-induced protein 4; tumor necrosis; B61; EFL1; EPLG1; LERK-1; TNFAIP4;
Efna1 involved in several pathways and played different roles in them. We selected most pathways Efna1 participated on our site, such as Arf6 signaling events, Axon guidance, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efna1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Efna1 has several biochemical functions, for example, ephrin receptor binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Efna1 itself. We selected most functions Efna1 had, and list some proteins which have the same functions with Efna1. You can find most of the proteins on our site.
Efna1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efna1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efna1.
EPHA2; PPBP; XRCC6; EEF1G; SUMO2; KAT5
Miao, H; Gale, NW; et al. EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties. ONCOGENE 34:558-567(2015).
McKinney, N; Yuan, LP; et al. EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma. JOURNAL OF NEURO-ONCOLOGY 121:109-118(2015).
