Recombinant Rat IL-17AF Heterodimer Protein
Cat.No. : | IL17A-142R |
Product Overview : | Recombinant Rat IL-17AF Heterodimer Protein without tag was expressed in E. coli. |
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Description : | Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17AF are active on mouse cells. |
Source : | E. coli |
Species : | Rat |
Bio-activity : | No biological activity data is available at this time. |
Molecular Mass : | Dimer, 30.2 kDa ((IL-17A=134; IL-17F=135; Total=269 amino acids) aa) |
AA Sequence : | IL-17A: MAVLIPQSSVCPNAEANNFLQNVKV NLKVLNSLSSKASSRRPSDYLNRST SPWTLSRNEDPDRYPSVIWEAQCRH QRCVNAEGKLDHHMNSVLIQQEILV LKREPEKCPFTFRVEKMLVGVGCTC VSSIVRHAS IL-17F: MARRNPKVGLSALQKAGNCPPLEDN SVRVDIRIFNQNQGISVPRDFQNRS SSPWDYNITRDPDRFPSEIAEAQCR HSGCINAQGQEDGSMNSVPIQQEIL VLRREPQGCSNSFRLEKMLIKVGCT CVTPIVHHAA |
Endotoxin : | ≤1 EUs/μg, Kinetic LAL |
Purity : | ≥95%, Reducing and Non-Reducing SDS PAGE |
Stability : | 12 months from date of receipt when stored at -20 to -80 centigrade as supplied. 1 month when stored at 4 centigrade after reconstituting as directed. 3 months when stored at -20 to -80 centigrade after reconstituting as directed. |
Storage : | Storage Prior to Reconstitution: -20 centigrade |
Storage Buffer : | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) |
Reconstitution : | Sterile water at 0.1 mg/mL |
Shipping : | Room temperature |
Instructions : | Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80 centigrade and avoid repeat freeze thaws. |
Gene Name : | Il17a interleukin 17A [ Rattus norvegicus (Norway rat) ] |
Official Symbol : | IL17A |
Synonyms : | IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); Il17; IL-17; CTLA-8; IL-17A; |
Gene ID : | 301289 |
mRNA Refseq : | NM_001106897 |
Protein Refseq : | NP_001100367 |
UniProt ID : | Q61453 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewGood for receptor studies.
Effective in Th17 differentiation.
High bioactivity in various tissue types.
Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
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