abcg2
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  • Official Full Name
  • ATP-binding cassette, sub-family G (WHITE), member 2
  • Background
  • The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
  • Synonyms
  • ABCG2; ATP-binding cassette, sub-family G (WHITE), member 2; MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; CDw338; UAQTL1; EST157481; ATP-binding cassette sub-family G member 2; urate exporter; ABC transporter; placenta specific MDR protein; breast cancer resistance protein; ATP-binding cassette transporter G2; mitoxantrone resistance-associated protein; placenta-specific ATP-binding cassette transporter; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2;
Cat.#:ABCG2-065HTag:N/A
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ABCG2 Protein
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Cat.#:ABCG2-066HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ABCG2 Protein, GST-Tagged
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Cat.#:ABCG2-067HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human ABCG2 Protein, GST-Tagged
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Cat.#:ABCG2-19HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ABCG2, GST-tagged
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Cat.#:ABCG2-5672HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ABCG2 protein, His-tagged
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Cat.#:ABCG2-659HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ABCG2
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Cat.#:ABCG2-1115MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ABCG2 Protein
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Cat.#:Abcg2-5673MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Abcg2 protein, His & T7-tagged
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Cat.#:ABCG2-414RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ABCG2 Protein
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Cat.#:ABCG2-184RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ABCG2 Protein, His-tagged
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Involved Pathway

ABCG2 involved in several pathways and played different roles in them. We selected most pathways ABCG2 participated on our site, such as ABC transporters, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ABC transporters
ABCB4; ABCB11; ABCB5; ABCC10; ABCC9; ABCC2; ABCC11; ABCD3; Abca2; ABCA13
Bile secretion
ADCY6; ATP1B3; NR1H4; SCTR; SLCO1A6; Abcb1b; SLCO1A4; SLC27A5; SLC22A8; ABCC2

Protein Function

ABCG2 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, heme transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG2 itself. We selected most functions ABCG2 had, and list some proteins which have the same functions with ABCG2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CDK1; RARS; NEK1; NTRK3; MKNK2A; KIF22; PIP5K1A; DDX54; ORC4L; DNA2
Function ATPase activity, coupled to transmembrane movement of substances
Related Protein ABCC5; ABCD2; ABCD4; ABCG5; ABCC3; ABCD3; ABCB1A; ABCG8; ABCC8; ABCD3B
Function heme transporter activity
Related Protein HPX; MFSD7B; SLC48A1A; MFSD7C; ABCB7; HRG-1; SLC48A1; ABCG2; FLVCR1; SLC48A1B
Function protein binding
Related Protein HOMEZ; SGTB; POU3F2; TMX3; TRIM54; ZBED1; DNAJC11; USP1; CENPI; DAK
Function protein homodimerization activity
Related Protein CCDC103; LSM1; ADD1; AP1S2; TGFB1; TREX1; ACTN1; OLIG2; HOGA1; IDH1
Function transporter activity
Related Protein SLC15A2; SLC5A8; SLC13A5A; TAP2; SYN1; HIATL1; ABCA7; ATP6V1C1; CHP; FABP6
Function xenobiotic-transporting ATPase activity
Related Protein ABCB4; ABCB1; ABCG2; ABCB1A; Abcb1b

Interacting Protein

ABCG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG2.
PIM1; UBC; Trim69

ABCG2 Related Articles

Diaz-Torne, C; Perez-Herrero, N; et al. New medications in development for the treatment of hyperuricemia of gout. CURRENT OPINION IN RHEUMATOLOGY 27:164-169(2015).
Zhao, MC; Zhang, YS; et al. Hypoxia-induced cell stemness leads to drug resistance and poor prognosis in lung adenocarcinoma. LUNG CANCER 87:98-106(2015).