actc1
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  • Official Full Name
  • Actin, Alpha, Cardiac Muscle 1
  • Background
  • Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus.
  • Synonyms
  • ACTC1; actin, alpha, cardiac muscle 1; ACTC; ASD5; CMD1R; CMH11; LVNC4; OTTHUMP00000160081; alpha-cardiac actin
Cat.#:ACTC1-214HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACTC1 Protein, GST-tagged
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Cat.#:ACTC1-6835HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTC1 protein, His & T7-tagged
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Cat.#:ACTC1-9333HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTC1, His-tagged
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Cat.#:ACTC1-1241MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACTC1 Protein
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Cat.#:Actc1-3089MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Actc1, His-tagged
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Cat.#:ACTC1-479RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACTC1 Protein
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Cat.#:ACTC1-3520CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACTC1
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Cat.#:ACTC1-5294HTag:N/A
Source (Host):Human HeartSpecies:Human
Product nameNative Human Actin, Alpha, Cardiac Muscle 1
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Cat.#:ACTC1-166BTag:
Source (Host):Species:Bovine
Product nameNative bovine ACTC1
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Cat.#:ACTC1-852BTag:
Source (Host):Bovine cardiac muscleSpecies:Bovine
Product nameNative Bovine ACTC1 Protein
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Cat.#:ACTC1-885BTag:
Source (Host):Bovine cardiacSpecies:Bovine
Product nameNative Bovine ACTC1 Protein, Pyrene labeled
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Cat.#:ACTC1-9065HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ACTC1 293 Cell Lysate
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Involved Pathway

ACTC1 involved in several pathways and played different roles in them. We selected most pathways ACTC1 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cardiac muscle contraction
UQCRC2B; CACNA1DA; TPM3; ATP1B1B; MYH7; RYR2; ATP1B3A; CACNA2D1; TPM2; TNNC1A
Adrenergic signaling in cardiomyocytes
PPP2R3C; TNNT2A; PIK3R5; CACNA2D1A; ATP1A1B; CALM; RAPGEF3; ADCY1A; CACNG3; CAMK2G
Hypertrophic cardiomyopathy (HCM)
CACNA2D1; TPM2; ITGB6; TTN; TGFB3; Itga10&Itgb1; ITGA8; CACNG4; PRKAG2; DES
Dilated cardiomyopathy
ITGA2B; CACNG3; LAMA2; PRKACG; DMD; ITGAV; TGFB2; TPM2; ITGB5; SGCG

Protein Function

ACTC1 has several biochemical functions, for example, ATP binding, ATPase activity, myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTC1 itself. We selected most functions ACTC1 had, and list some proteins which have the same functions with ACTC1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYO6B; ABCC10; PAK2; SHPRH; ERCC6L; HSPA4A; ABCF3; P2RX5; NRK; SMYHC3
Function ATPase activity
Related Protein ABCB6; ABCG5; ABCF3; EIF4A1A; VPS4A; PICK1; EIF4A1B; HLTF; ABCB4; ABCA6
Function myosin binding
Related Protein RHOA; ARFGEF1; KIRREL; VAMP2; TRIM32; VETZ; GIPC1; CALM; FXYD1; CALD1

Interacting Protein

ACTC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTC1.
ESR1; GAPDH; C1QTNF9; MYBPC3; TNNI3K; TRIM63; BCL11A; ASH2L; MPC1; ere_dna; MYC; VCAM1; ARRB2; HTR7; MYH9

ACTC1 Related Articles

Tian, T; Wang, JZ; et al. A low prevalence of sarcomeric gene variants in a Chinese cohort with left ventricular non-compaction. HEART AND VESSELS 30:258-264(2015).
Chen, CD; Yu, ZQ; et al. Evaluating the Association between Pathological Myopia and SNPs in RASGRFI, ACTCI and GJD2 Genes at Chromosome 15q14 and 15q25 in a Chinese Population. OPHTHALMIC GENETICS 36:1-7(2015).