acvr1b
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  • Official Full Name
  • activin A receptor, type 1B
  • Background
  • This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a hete
  • Synonyms
  • ACVR1B; activin A receptor, type 1B; activin receptor type-1B; ALK-4; activin receptor type IB; activin receptor-like kinase 4; serine/threonine-protein kinase receptor R2; Alk4; SKR2; ActRIB; ActR-IB; Acvrlk4; 6820432J04
Cat.#:ACVR1B-332HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1B Protein, Fc-tagged
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Cat.#:ACVR1B-287HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACVR1B Protein, His-tagged
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Cat.#:Acvr1b-288MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Acvr1b Protein, His-tagged
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Cat.#:ACVR1B-2596HTag:N/A
Source (Host):BTI-Tn-5B1-4 cellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type IB
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Cat.#:ACVR1B-189HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human ACVR1B, Fc Chimera
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Cat.#:ACVR1B-231HTag:GST|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACVR1B protein, GST/His-tagged
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Cat.#:ACVR1B-249HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ACVR1B Protein, GST-tagged
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Cat.#:ACVR1B-250HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACVR1B Protein, GST-tagged
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Cat.#:ACVR1B-528HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACVR1B, Fc-tagged, Biotinylated
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Cat.#:ACVR1B-529HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACVR1B, Fc-tagged
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Cat.#:ACVR1B-560HTag:Fc|His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1B, Fc-His tagged
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Cat.#:ACVR1B-645HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1B, His tagged
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Cat.#:Acvr1b-586MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Acvr1b Protein, Fc Chimera
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Cat.#:Acvr1b-975MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Acvr1b Protein, Fc-tagged
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Cat.#:ACVR1B-492RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACVR1B Protein
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Cat.#:Acvr1b-8721RTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Acvr1b, Fc tagged
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Cat.#:ACVR1B-8815CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR1B, Fc tagged
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Cat.#:ACVR1B-231RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ACVR1B Protein, His-tagged
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Cat.#:ACVR1B-5295HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type IB, GST-tagged
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Cat.#:ACVR1B-1584HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Activin A Receptor, Type IB
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Cat.#:ACVR1B-1916HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Activin A Receptor, Type IB
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Cat.#:ACVR1B-240HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type IB, GST-tagged, Active
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Cat.#:ACVR1B-2130HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR1B cell lysate
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Cat.#:ACVR1B-1206RCLTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat ACVR1B cell lysate
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Cat.#:ACVR1B-1356CCLTag:N/A
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR1B cell lysate
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Involved Pathway

ACVR1B involved in several pathways and played different roles in them. We selected most pathways ACVR1B participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCR6; Ccl9; CXCR2; EGFRA; RNF207B; IL9; TNFRSF18; GH2; EDAR; TNFRSF14
TGF-beta signaling pathway
ZFYVE9; ACVR1C; BMPR1BA; RPS6KB2; ID1; BMPR1A; SKP1; BMP7B; ROCK1; BMPR1AB
Signaling pathways regulating pluripotency of stem cells
MYF5; SMAD4; WNT5B; IGF1; NRAS; TBX3; PIK3CA; FGFR2; HNF1A; SMAD5

Protein Function

ACVR1B has several biochemical functions, for example, ATP binding, SMAD binding, contributes_to activin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR1B itself. We selected most functions ACVR1B had, and list some proteins which have the same functions with ACVR1B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DHX8; NAT1; PI4KA; HSPE1; NEK5; ACSL3; NEK1; GSK3AA; DDX18; EIF4A1
Function SMAD binding
Related Protein PURA; ACVRL1; YY1; USP15; SMURF2; BMP2; SKOR1; SKOR2; FKBP1A; SKIL
Function contributes_to activin binding
Related Protein ACVR2A; ACVR1B
Function activin receptor activity, type I
Related Protein ACVR1C; ACVRL1; ACVR1B
Function contributes_to activin-activated receptor activity
Related Protein ACVR1B; ACVR2A
Function contributes_to growth factor binding
Related Protein ACVR1B; TGFBR1; IL6ST; ERBB2
Function inhibin binding
Related Protein INHBA; INHA; ACVR1B; ACVR2A; IGSF1
Function metal ion binding
Related Protein ATP2A3; CHORDC1B; PPM1DB; ATF7; NAIP1; ZNF480; ABLIM1B; LMAN2; NPEPPS; GNAI1
Function protein binding
Related Protein ZKSCAN3; PCSK2; CA1; CPT1B; ASTE1; SYNPO2L; HGF; BATF3; TAGLN; LGR5
Function protein serine/threonine kinase activity
Related Protein DAPK2; MAPK8B; FASTK; MAP4K5; CAMKK1B; CDK12; CASK; ACVR1; GSK3B; GM711
Function receptor signaling protein serine/threonine kinase activity
Related Protein ACVR1L; SLKA; TGFBR1A; STK24B; BMPR1AA; ACVR1; STK25A; BMPR2; STK24A; ALPK2
Function transmembrane receptor protein serine/threonine kinase activity
Related Protein BMPR1BB; TGFBR2; ALPK2; BMPR2A; ACVRL1; TGFBR1B; BMPR1AB; ACVR2A; BMPR1A; BMPR2B
Function ubiquitin protein ligase binding
Related Protein UBE2K; GPR37; PARK2; TPI1; MAGEA2B; UBE2G2; HSPA5; CCT2; IKBKG; ARRB2

Interacting Protein

ACVR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR1B.
SMAD7; HSP90AB1; FKBP1A; XIAP; RXRA; PRKACB; BAG6; OS9; bosutinib