Active Recombinant Human ACVR1B, Fc-tagged, Biotinylated
| Cat.No. : | ACVR1B-528H |
| Product Overview : | The recombinant human ACVR1B-Fc fusion protein is expressed as a 331 amino acid protein consisting of Ser24 - Glu126 region of ACVR1B (UniProt accession #P36896) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition. |
- Specification
- Gene Information
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| Source : | Human cells |
| Species : | Human |
| Tag : | Fc |
| Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
| Bio-activity : | Immobilized ACVR1B binds human Cripto in a functional ELISA. Blocks Cripto-mediated signaling activity. |
| Molecular Mass : | Calculated molecular mass (kDa): 37.0; Estimated by SDS-PAGE under reducing condition (kDa): ~45 |
| AA Sequence : | SGPRGVQALLCACTSCLQANYTCET DGACMVSIFNLDGMEHHVRTCIPKV ELVPAGKPFYCLSSEDLRNTHCCY TDYCNRIDLRVPSGHLKEPEHPSMW GPVESTGTHTCPPCPAPELLGGPSV FLFPPKPKDTLMISRTPEVTCVV VDVSHEDPEVKFNWYVDGVEVHNAK TKPREEQYNSTYRVVSVLTVLHQDW LNGKEYKCKVSNKALPAPIEKTIS KAKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQP ENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNH YTQKSLSLSPGK |
| Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the |
| Purity : | >95% judged by SDS-PAGE under reducing condition |
| Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
| Gene Name : | ACVR1B activin A receptor, type IB [ Homo sapiens ] |
| Official Symbol : | ACVR1B |
| Synonyms : | ACVR1B; activin A receptor, type IB; ACVRLK4; activin receptor type-1B; ActRIB; ALK4; SKR2; activin receptor-like kinase 4; activin A receptor, type II-like kinase 4; serine/threonine-protein kinase receptor R2; ACTRIB; |
| Gene ID : | 91 |
| mRNA Refseq : | NM_004302 |
| Protein Refseq : | NP_004293 |
| MIM : | 601300 |
| UniProt ID : | P36896 |
| Chromosome Location : | 12q13 |
| Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Developmental Biology, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; Regulation of Signaling by NODAL, organism-specific biosystem; Signaling by NODAL, organism-specific biosystem; |
| Function : | ATP binding; SMAD binding; contributes_to activin binding; activin receptor activity, type I; activin receptor activity, type I; contributes_to activin-activated receptor activity; contributes_to growth factor binding; inhibin binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; receptor activity; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; ubiquitin protein ligase binding; |
Products Types
| ◆ Recombinant Protein | ||
| ACVR1B-1288H | Recombinant Human ACVR1B Protein (N150-I505), Tag Free | +Inquiry |
| ACVR1B-165H | Recombinant Human ACVR1B Protein, His (Fc)-Avi-tagged | +Inquiry |
| ACVR1B-59R | Recombinant Rhesus Macaque ACVR1B Protein, His (Fc)-Avi-tagged | +Inquiry |
| Acvr1b-1M | Recombinant Mouse Acvr1b Protein, His (Fc)-Avi-tagged | +Inquiry |
| ACVR1B-082H | Recombinant Human ACVR1B Protein, Fc-tagged | +Inquiry |
| ◆ Lysates | ||
| ACVR1B-1206RCL | Recombinant Rat ACVR1B cell lysate | +Inquiry |
| ACVR1B-2130HCL | Recombinant Human ACVR1B cell lysate | +Inquiry |
| ACVR1B-1356CCL | Recombinant Cynomolgus ACVR1B cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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