acy1
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  • Official Full Name
  • aminoacylase 1
  • Background
  • This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
  • Synonyms
  • ACY1; aminoacylase 1; aminoacylase-1; acylase; N-acyl-L-amino-acid amidohydrolase; ACY-1; ACY1D
Cat.#:ACY1-1152HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ACY1 Protein, DDK-tagged
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Cat.#:ACY1-1153HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACY1 Protein, MYC/DDK-tagged
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Cat.#:ACY1-487HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACY1 Protein, His-tagged
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Cat.#:ACY1-26570THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACY1, His-tagged
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Cat.#:ACY1-27198THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACY1, His-tagged
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Cat.#:ACY1-781HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aminoacylase 1, His-tagged
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Cat.#:ACY1-27HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aminoacylase 1, T7-tagged
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Cat.#:ACY1-165HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACY1 protein, T7-tagged
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Cat.#:ACY1-242HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ACY1, His tagged
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Cat.#:ACY1-262HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACY1 Protein, GST-tagged
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Cat.#:ACY1-327HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ACY1 Protein, DDK-tagged
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Cat.#:Acy1-111MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Acy1, His-tagged
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Cat.#:Acy1-1128MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Acy1, His tagged
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Cat.#:Acy1-758MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Acy1 Protein, His-tagged
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Cat.#:ACY1-497RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACY1 Protein
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Cat.#:ACY1-8280ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACY1
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Cat.#:ACY1-725HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ACY1 cell lysate
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Cat.#:ACY1-3095MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACY1 cell lysate
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Involved Pathway

ACY1 involved in several pathways and played different roles in them. We selected most pathways ACY1 participated on our site, such as Arginine biosynthesis, Metabolic pathways, -Oxocarboxylic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arginine biosynthesis
GLULA; GLULB; ybaS; GPT2; GOT2A; GLUD1A; GLUD1; GLS; ARG1; GOT1
Metabolic pathways
HMGCRA; ATP6V1G2; AKR1B10; URAD; cysH; IMPDH1; FUT9; COMTB; SPRA; PCYT2
-Oxocarboxylic acid metabolism
GPT2; GOT2; GOT1; IDH3G; ACO2; GPT; AADAT; ACO1; ACY1; GOT2B
Biosynthesis of amino acids
PFKMB; NAGS; TKTL2; TAT; ARG2; GPT2L; PFKM; AADAT; BCAT2; PFKMA

Protein Function

ACY1 has several biochemical functions, for example, aminoacylase activity, metal ion binding, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACY1 itself. We selected most functions ACY1 had, and list some proteins which have the same functions with ACY1. You can find most of the proteins on our site.
Function
Related Protein
Function aminoacylase activity
Related Protein ACY3; ASPA; CAT; ACY1; DARS
Function metal ion binding
Related Protein CYP2C50; GYG1; TATDN1; PPP2R3C; MGAT5B; Car4; ZFP330; ZFP740; ZNF383; MCCC1
Function metallopeptidase activity
Related Protein PAPLNB; ADAM25; MMP14B; HE1B; ENPEP; BMP1; YME1L1; ADAM5; ADAM10A; ADAM8A
Function protein binding
Related Protein SOX-2; TMED2; NUDT1; IFI16; BLMH; ATXN1L; SPG7; ROR2; SIN3B; SCOC

Interacting Protein

ACY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACY1.
TERF1; TFAP2A; NPM1; BBS7; BBS4; TTC1; BBS2; POT1; GSTP1