adam2
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  • Official Full Name
  • ADAM metallopeptidase domain 2
  • Background
  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.
  • Synonyms
  • ADAM2; ADAM metallopeptidase domain 2; fertilin beta , FTNB; disintegrin and metalloproteinase domain-containing protein 2; cancer/testis antigen 15; CT15; PH 30b; PH30; A disintegrin and metalloproteinase domain 2; ADAM 2; ADAM2_HUMAN; AI323749; CRYN1; CRYN2; Fertilin beta; Fertilin subunit beta; Ftnb; PH 30; PH-30; Ph30 beta; PH30-beta; OTTHUMP00000225677; OTTHUMP00000225678; OTTHUMP00000225679; OTTHUMP00000225680; PH-30b
Cat.#:ADAM2-279HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAM2 Protein, GST-tagged
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Cat.#:ADAM2-280HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAM2 Protein, GST-tagged
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Cat.#:ADAM2-1284MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADAM2 Protein
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Cat.#:ADAM2-503RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADAM2 Protein
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Cat.#:ADAM2-276CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ADAM2 Protein, His-tagged
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Cat.#:ADAM2-22HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ADAM2 cell lysate
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Involved Pathway

ADAM2 involved in several pathways and played different roles in them. We selected most pathways ADAM2 participated on our site, such as Fertilization, Interaction With The Zona Pellucida, Reproduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fertilization
OVGP1; IZUMO1; ADAM30; CATSPERG2; ZP2; CATSPER2; CATSPERB; ADAM2; Acr; TMEM146
Interaction With The Zona Pellucida
ADAM20; ADAM30; OVGP1; ADAM21; ADAM2; ZP3; ZP2
Reproduction
ADAM2; CATSPER2; IZUMO1; CATSPERG1; ADAM30; TMEM146; CATSPER1; ADAM20; ZP3; CATSPER3

Protein Function

ADAM2 has several biochemical functions, for example, integrin binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM2 itself. We selected most functions ADAM2 had, and list some proteins which have the same functions with ADAM2. You can find most of the proteins on our site.
Function
Related Protein
Function integrin binding
Related Protein ICAM1; NF2; THBS4; NIPAL1; VWF; PXN; TNN; DST; WISP2; Npnt
Function metalloendopeptidase activity
Related Protein ADAMDEC1; ADAMTS20; ADAMTSL5; ADAMTS15A; MMP14; MME; MEP1A.2; MMP25; YME1L1; ADAM10A
Function metallopeptidase activity
Related Protein ADAM20; MEP1A.1; ADAM18; ANPEPA; ADAMTS15A; ADAM5; BRCC3; NPSN; MMP1A; CLCA5
Function zinc ion binding
Related Protein RNF220; ADAM1B; XIAP; SP140; NR2C2; RAPSN; LIMS1; DPYS; RNF19A; RUNX1

ADAM2 Related Articles

Desiderio, UV; Zhu, XL; et al. ADAM2 Interactions with Mouse Eggs and Cell Lines Expressing alpha(4)/alpha(9) (ITGA4/ITGA9) Integrins: Implications for Integrin-Based Adhesion and Fertilization. PLOS ONE 5:-(2010).
Murase, SI; Cho, C; et al. ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb. EUROPEAN JOURNAL OF NEUROSCIENCE 27:1585-1595(2008).