AFP Protein, alpha-fetoprotein

AFP

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AFP

Official Full Name alpha-fetoprotein
Background This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
Synonyms AFP; alpha-fetoprotein; FETA; HPAFP; alpha-fetoglobulin; alpha-1-fetoprotein;
    • Species :
    • Cattle
    • Dog
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Human Cord Blood
    • Human Cord Serum
    • Human Fetal Cord Serum
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • HlgG1 Fc
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AFP-1059H Recombinant Human AFP Protein (Met1-Val609), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Mouse Afp-552M Recombinant Mouse Afp Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human AFP-1180H Native Human Alpha-Fetoprotein Human Cord Blood N/A
    Human AFP-120H Recombinant Human AFP Protein, His-tagged E.coli His
    Human AFP-121H Recombinant Human AFP Protein, His-tagged E.coli His
    Human AFP-1706HCL Recombinant Human AFP cell lysate Human Cell N/A
    Human AFP-1H Alfafoetoprotein (AFP) Reference Standard N/A
    Human AFP-225H Recombinant Human AFP, StrepII-tagged Human Cell Strep II
    Human AFP-29H Recombinant Human AFP protein, M2 Peptide fused E.coli N/A
    Human AFP-3017H Native Human fetal cord serum Human Fetal Cord Serum N/A
    Human AFP-3018P Native pig AFP Human Cord Serum N/A
    Human AFP-412H Native Human AFP Protein Human N/A
    Human AFP-413H Recombinant Human AFP Protein, GST-tagged Wheat Germ GST
    Human AFP-4180H Purified Human Alpha-Fetoprotein Human N/A
    Human AFP-4769H Human Alpha-Fetoprotein Human Cord Serum N/A
    Human AFP-48H Recombinant Human Alpha-Fetoprotein Yeast N/A
    Human AFP-52H Recombinant Human AFP protein, His-tagged Insect Cell His
    Human AFP-545H Recombinant Human AFP Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AFP-6858H Recombinant Human AFP, His tagged Human Cell His
    Human AFP-8027H Native Human Alpha FetoProtein Human Cord Blood N/A
    Human AFP-9461H Recombinant Human AFP, His-tagged E.coli His
    Mouse Afp-122M Recombinant Mouse Afp Protein, His-tagged E.coli His
    Mouse AFP-1404M Recombinant Mouse AFP Protein Mammalian Cell His
    Mouse Afp-3366M Recombinant Mouse Afp, His-tagged E.Coli or Yeast His
    Rat Afp-126R Recombinant Rat Afp Protein, His/GST-tagged E.coli His/GST
    Dog AFP-119D Recombinant Dog AFP Protein, His-tagged E.coli His
    Cattle AFP-118C Recombinant Cattle AFP Protein, His-tagged E.coli His
    Pig AFP-123P Recombinant Pig AFP Protein, His/GST-tagged E.coli His/GST
    Pig AFP-124P Recombinant Pig AFP Protein, His/GST-tagged E.coli His/GST
    Pig AFP-125P Recombinant Pig AFP Protein, His/GST-tagged E.coli His/GST
    Pig aFP-3365P Recombinant Pig aFP, His-tagged, GST-tagged E.coli His/GST
    CDA001 Human Alpha Fetoprotein Antigen Grade Human Fetal Cord Serum N/A

    AFP involved in several pathways and played different roles in them. We selected most pathways AFP participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AFP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hippo signaling pathway NKD1; GLI2; CRB1; SNAI2; TCF7L2; LLGL2; FZD6; SMAD2; APC; FGF1

    AFP has several biochemical functions, for example, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFP itself. We selected most functions AFP had, and list some proteins which have the same functions with AFP. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding SUCLA2; CRYABA; SPON2; FBXO40.1; ADCY1; TIMP4; PARN; ATP1A1A.3; CYP8B1; IRF2BP2A

    AFP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFP here. Most of them are supplied by our site. Hope this information will be useful for your research of AFP.

    Li, L; Xia, LR; et al. New method for fabricating an alpha-fetoprotein affinity monolithic polymer array. JOURNAL OF APPLIED POLYMER SCIENCE 132:-(2015).
    Liu, YJ; Li, JS; et al. Theranostic Polymeric Micelles for the Diagnosis and Treatment of Hepatocellular Carcinoma. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 11:613-622(2015).

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