akr1c3
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  • Official Full Name
  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
  • Background
  • Aldo-Keto Reductase AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9alpha,11beta- PGF2 to PGD2. AKR1C3 can interconvert acti
  • Synonyms
  • AKR1C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD17B5, hydroxysteroid (17 beta) dehydrogenase 5; aldo-keto reductase family 1 member C3; DDX; dihydrodiol dehydrogenase X; HAKRB; KIAA0119; PGFS; prostagla
Cat.#:AKR1C3-26146THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C3, His-tagged
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Cat.#:AKR1C3-413HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKR1C3 Protein, GST-tagged
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Cat.#:AKR1C3-9533HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKR1C3, GST-tagged
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Cat.#:AKR1C3-600RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKR1C3 Protein
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Cat.#:AKR1C3-49HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AKR1C3 cell lysate
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Involved Pathway

AKR1C3 involved in several pathways and played different roles in them. We selected most pathways AKR1C3 participated on our site, such as Steroid hormone biosynthesis, Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Steroid hormone biosynthesis
HSD17B12A; HSD17B7; HSD17B6; HSD3B1; CYP2D10; CYP2C54; HSD11B2; PPP1R2; HSD17B2; UGT1A6
Arachidonic acid metabolism
GGT5A; GPX6; PLB1; CYP2P6; PLA2G12A; CYP2C55; ALOX5AP; PLA2G4AA; FAAH2B; AKR1C21
Metabolic pathways
GUK1B; PCCA; GCLC; ATP6V1G3; POLR3GL; DHRS4L2; MDH1AA; NME1-NME2; HAAO; SDHDB
Ovarian steroidogenesis
AKR1C3; HSD3B2; PLA2G4A; ACOT2; INS; HSD17B7; ALOX5; HSD3B1; HSD3B5; CYP2J6

Protein Function

AKR1C3 has several biochemical functions, for example, 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, alditol:NADP+ 1-oxidoreductase activity, aldo-keto reductase (NADP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1C3 itself. We selected most functions AKR1C3 had, and list some proteins which have the same functions with AKR1C3. You can find most of the proteins on our site.
Function
Related Protein
Function 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
Related Protein AKR1C3
Function alditol:NADP+ 1-oxidoreductase activity
Related Protein AKR1B1; PRKRA; AKR1A1; AKR1B8; AKR7A2; AKR1C3; AKR1C21; AKR1C2; ADH4; Akr1b3
Function aldo-keto reductase (NADP) activity
Related Protein AKR1C6; KCNAB2; AKR1C3; AKR1B10; AKR1B1; AKR1C21; HSD11B1LA; HSD3B6; HSD3B5; SDR42E1
Function androsterone dehydrogenase activity
Related Protein AKR1C3; AKR1C21; AKR1C4; AKR1C6
Function delta4-3-oxosteroid 5beta-reductase activity
Related Protein AKR1D1; AKR1C3
Function dihydrotestosterone 17-beta-dehydrogenase activity
Related Protein SDR42E1; H2-KE6; HSD11B1LA; AKR1C3; HSD3B5; AKR1C6; SDR16C6; AKR1C21; HSD3B6
Function geranylgeranyl reductase activity
Related Protein AKR1B10; AKR1B8; AKR1C3
Function indanol dehydrogenase activity
Related Protein AKR1C3; AKR1B10; AKR1B8
Function ketoreductase activity
Related Protein DHRS7CB; DHRS7CA; AKR1C3
Function ketosteroid monooxygenase activity
Related Protein AKR1C21; AKR1C3; AKR1C2
Function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Related Protein DHRS4; AKR1C4; AKR1C6; AKR1C21; NDUFS7; AKR1C3; CBR1; DCXR; AKR1C2
Function phenanthrene 9,10-monooxygenase activity
Related Protein MICAL2B; AKR1C3; AKR1C2; AKR1C21; MICAL2
Function prostaglandin D2 11-ketoreductase activity
Related Protein AKR1C3
Function prostaglandin-F synthase activity
Related Protein AKR1C3; FAM213B
Function retinal dehydrogenase activity
Related Protein AKR1B8; AKR1C4; AKR1C3; ALDH1A3; ALDH8A1; Aldh1a7; ALDH1A1; AKR1C6; AKR1B10
Function retinol dehydrogenase activity
Related Protein RDH8; ADH7; DHRS7C; RDH11; ADH1; RDH7; SDR16C5; RDH5; SDR9C7; ADH4
Function testosterone 17-beta-dehydrogenase (NADP+) activity
Related Protein AKR1C3; HSD17B3; HSD17B14; AKR1C6
Function testosterone dehydrogenase (NAD+) activity
Related Protein DHRS9; HSD17B2; HSD17B1; HSD17B8; AKR1C3; H2-KE6; HSD17B6
Function trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Related Protein AKR1C21; AKR1C3; DHDH; AKR1C2

Interacting Protein

AKR1C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1C3.
MAGEA11; RIF1; UBE2W; ACIN1; ZHX1

AKR1C3 Related Articles

Chen, CC; Chu, CB; et al. Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification. BIOCHEMICAL PHARMACOLOGY 86:872-887(2013).
Gram, A; Buchler, U; et al. Biosynthesis and Degradation of Canine Placental Prostaglandins: Prepartum Changes in Expression and Function of Prostaglandin F2alpha-Synthase (PGFS, AKR1C3) and 15-Hydroxyprostaglandin Dehydrogenase (HPGD). BIOLOGY OF REPRODUCTION 89:-(2013).