Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

ANGPTL3

  • Official Full Name

    angiopoietin-like 3

  • Overview

    This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
  • Synonyms

    ANGPTL3; angiopoietin-like 3; ANL3; ANG-5; FHBL2; ANGPT5; angiopoietin-related protein 3; angiopoietin 5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Zebrafish
  • Baculovirus-Insect Cells
  • CHO
  • E.coli
  • Hamster
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Wheat Germ
  • Fc
  • Flag
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • HA
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANGPTL3-555H Active Recombinant Human ANGPTL3 protein, His-tagged Hamster His
Human ANGPTL3-2199H Active Recombinant Human ANGPTL3 protein, His-tagged HEK293 His Ser 17 - Glu 460
Human ANGPTL3-117H Recombinant Human ANGPTL3 Protein, His-tagged E.coli His 26-233 a.a.
Human ANGPTL3-397H Recombinant Human ANGPTL3, FLAG-tagged HEK293 Flag
Human ANGPTL3-101H Recombinant Human ANGPTL3, His-tagged E.coli His
Human ANGPTL3-399H Recombinant Human ANGPTL3 Protein, FLAG-tagged HEK293 FLAG
Human ANGPTL3-9649H Recombinant Human ANGPTL3, GST-tagged E.coli GST C-term-220a.a.
Human ANGPTL3-556H Recombinant Human ANGPTL3 protein, GST-tagged Wheat Germ GST
Human ANGPTL3-176H Recombinant Human ANGPTL3 protein, His-tagged HEK293 His Ser17-Pro220
Human ANGPTL3-32H Recombinant Human ANGPTL3 protein, His-tagged E.coli His
Human ANGPTL3-8862HCL Recombinant Human ANGPTL3 293 Cell Lysate HEK293 N/A
Human ANGPTL3-842H Recombinant Human ANGPTL3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANGPTL3-432H Recombinant Human ANGPTL3 Protein (Met1-Glu460), His-tagged Insect Cell His Met1-Glu460
Human ANGPTL3-27353TH Recombinant Human ANGPTL3, FLAG-tagged HEK293 FLAG 237 amino acids
Human ANGPTL3-1227HF Recombinant Full Length Human ANGPTL3 Protein, GST-tagged In Vitro Cell Free System GST 460 amino acids
Human ANGPTL3-177H Recombinant Human ANGPTL3(Ser17-Pro220) Protein, C-Fc-tagged HEK293 Fc
Human ANGPTL3-1785HFL Recombinant Full Length Human ANGPTL3 Protein, C-Flag-tagged Mammalian cells Flag
Human ANGPTL3-951H Recombinant Human ANGPTL3 protein, His-Avi-tagged HEK293 His-Avi Ser17-Lys 219
Human ANGPTL3-340H Recombinant Human ANGPTL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ANGPTL3-485H Recombinant Human ANGPTL3 Protein 460
Human ANGPTL3-0125H Recombinant Human ANGPTL3 Protein (Gly241-Glu460), N-His-tagged E.coli N-His Gly241-Glu460
Human ANGPTL3-951HB Recombinant Human ANGPTL3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Ser17 - Lys 219.
Human ANGPTL3-26574TH Recombinant Human ANGPTL3, FLAG-tagged HEK293 FLAG 460 amino acids
Human ANGPTL3-2890H Active Recombinant Human ANGPTL3 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ser 17-Pro 220
Human ANGPTL3-340H-B Recombinant Human ANGPTL3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ANGPTL3-2200M Active Recombinant Mouse ANGPTL3 protein, His-tagged HEK293 His Ser 17 - Thr 455
Mouse ANGPTL3-398M Recombinant Mouse ANGPTL3, Coiled-Coil Domain, His-tagged HEK293 His
Mouse Angptl3-1819M Recombinant Mouse Angptl3 protein, His & GST-tagged E.coli His/GST Thr237~Thr455 (Accession # Q9R182)
Mouse Angptl3-1820M Recombinant Mouse Angptl3 protein, His & T7-tagged E.coli His/T7 Asp22~Pro281 (Accession # Q9R182)
Mouse ANGPTL3-401M Recombinant Mouse Angiopoietin-like 3, FLAG-tagged HEK293 Flag
Mouse Angptl3-173M Active Recombinant Mouse Angptl3 Protein, His-tagged, Biotinylated CHO His Ser17-Thr206
Mouse Angptl3-5438M Recombinant Mouse Angptl3 Protein (Ser17-Arg224), N-His tagged E.coli N-His Ser17-Arg224
Mouse ANGPTL3-394M Active Recombinant Mouse ANGPTL3 Protein, His-tagged Insect Cell His Met1-Ser220
Mouse ANGPTL3-783M Recombinant Mouse ANGPTL3 Protein (Met1-Thr455), His-tagged Insect Cell His Met1-Thr455
Mouse Angptl3-1626M Recombinant Mouse Angptl3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Angptl3-174M Active Recombinant Mouse Angptl3 Protein, N-HA-tagged NS0 N-HA
Cynomolgus ANGPTL3-178C Recombinant Cynomolgus ANGPTL3 protein (Met1-Pro220), His-tagged Baculovirus-Insect Cells His
Zebrafish ANGPTL3-9329Z Recombinant Zebrafish ANGPTL3 Mammalian Cell His
Chicken ANGPTL3-3866C Recombinant Chicken ANGPTL3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANGPTL3 Related Articles
  • ANGPTL3 Related Research Area

ANGPTL3 involved in several pathways and played different roles in them. We selected most pathways ANGPTL3 participated on our site, such as Integrins in angiogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPTL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Integrins in angiogenesisEDIL3;ANGPTL3;CSF1;MFGE8;CSF1R

ANGPTL3 has several biochemical functions, for example, enzyme inhibitor activity, growth factor activity, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPTL3 itself. We selected most functions ANGPTL3 had, and list some proteins which have the same functions with ANGPTL3. You can find most of the proteins on our site.

Function Related Protein
enzyme inhibitor activityPLN;CALU;UGT1A9;APBA3;HSPBP1;ATPIF1A;APOV1;DGKZ;UGT1A1
growth factor activityTHBS4;FGF20B;TDGF1;CSF1B;MSTNA;VEGFAA;Fgf15;TGFA;LFT2
integrin bindingWISP3;CXADR;PPAP2B;COL16A1;FBN1;COL5A1;ITGB1BP1;ADAMTS8;FAP
phospholipase inhibitor activityANXA2B;ANXA1B;ANXA3B;APOC1;ANGPTL3;SNCB;ANXA1A;ANXA1C;ANXA4

ANGPTL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPTL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPTL3.

ITGAV

Nakajima, K; Kobayashi, J; et al. Antibodies to human angiopoietin-like protein 3: a patent evaluation of WO2012174178. EXPERT OPINION ON THERAPEUTIC PATENTS 24:113-119(2014).
Chou, S; Lodish, HF; et al. Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:7799-7804(2010).
  • Q&As
  • Reviews

Q&As (27)

Ask a question
Are there any ongoing research studies related to ANGPTL3? 05/01/2023

Yes, research on ANGPTL3 is ongoing. Studies are being conducted to better understand its mechanisms of action, explore its potential therapeutic applications, and assess its long-term effects.

Is ANGPTL3 genetic testing available? 02/03/2023

Yes, genetic testing for ANGPTL3 mutations can help identify individuals who may benefit from ANGPTL3-targeted therapies, although it is not currently a routine clinical practice and is typically reserved for research or specialized testing purposes.

Are there any side effects associated with ANGPTL3-targeted therapies? 01/15/2023

The side effects of ANGPTL3-targeted therapies are still being investigated. However, some studies have reported mild side effects, such as injection site reactions, headache, and muscle pain. It is important to consult with a healthcare professional for more specific information on the potential side effects of ANGPTL3-targeted therapies.

Is ANGPTL3 deficiency a rare condition? 08/15/2021

Yes, ANGPTL3 deficiency is a relatively rare condition. It is usually caused by specific genetic mutations that impair ANGPTL3 production or function. The prevalence of ANGPTL3 deficiency in the general population is estimated to be very low.

Can ANGPTL3 therapies be used in combination with other cholesterol-lowering medications? 08/24/2020

Combination therapy with ANGPTL3 inhibitors and other cholesterol-lowering medications, such as statins, has shown potential for achieving more significant reductions in LDL cholesterol and triglyceride levels. However, the safety and efficacy of combining ANGPTL3 therapies with other medications may vary, and it is important to consult with a healthcare professional for personalized treatment recommendations.

Can ANGPTL3-targeted therapies be used as a preventive measure for cardiovascular disease? 01/26/2020

ANGPTL3-targeted therapies have the potential to reduce the risk of cardiovascular disease by lowering LDL cholesterol and triglyceride levels. However, their exact role as a preventive measure is still being investigated, and more research is needed to determine their long-term efficacy and benefits in preventing heart disease.

Have ANGPTL3-targeted therapies shown promising results in clinical trials? 10/09/2019

Yes, clinical trials investigating ANGPTL3-targeted therapies have shown promising results in reducing LDL cholesterol and triglyceride levels in individuals with a genetic predisposition to high lipid levels.

Can ANGPTL3 gene variations affect an individual's response to lipid-lowering drugs? 03/05/2019

Genetic variations in the ANGPTL3 gene may potentially affect an individual's response to lipid-lowering drugs. Certain variations may influence how an individual's body metabolizes and responds to these medications, leading to differences in their effectiveness. However, more research is needed to fully understand the impact of ANGPTL3 gene variations on drug response.

Are there any potential therapies targeting ANGPTL3? 02/23/2019

ANGPTL3 inhibitors, such as monoclonal antibodies or antisense oligonucleotides, are being explored as potential therapeutic approaches to reduce ANGPTL3 activity and lower lipid levels.

Can ANGPTL3-targeted therapies be used in combination with other cholesterol-lowering medications? 01/30/2019

The potential interactions between ANGPTL3-targeted therapies and other cholesterol-lowering medications are still being studied. Combining these therapies with other medications may show additive or synergistic effects, but further research is needed to determine their compatibility and safety.

What are the potential benefits of ANGPTL3-targeted therapies? 11/17/2018

ANGPTL3-targeted therapies have the potential to lower LDL cholesterol and triglyceride levels, which are both risk factors for cardiovascular disease. By reducing ANGPTL3 activity, these therapies may help reduce the risk of heart disease and related complications.

How is ANGPTL3 related to cardiovascular disease? 11/07/2018

ANGPTL3 has been associated with an increased risk of cardiovascular disease. Elevated levels of ANGPTL3 have been found to be a risk factor for atherosclerosis, coronary artery disease, and other cardiovascular events. Inhibiting ANGPTL3 activity has shown promise in reducing cardiovascular risk factors, such as LDL cholesterol and triglyceride levels.

Are there any clinical trials investigating ANGPTL3 therapies? 06/22/2018

There have been and continue to be clinical trials investigating ANGPTL3 therapies. These trials aim to evaluate the safety and efficacy of various drug candidates targeting ANGPTL3 in treating hyperlipidemia and related disorders.

Are there any genetic mutations related to ANGPTL3? 05/02/2018

Yes, there have been identified genetic mutations in the ANGPTL3 gene that can lead to significantly reduced or absent ANGPTL3 protein production. These mutations have been associated with lower levels of LDL cholesterol, triglycerides, and higher levels of high-density lipoprotein (HDL) cholesterol, resulting in the condition called familial hypobetalipoproteinemia.

Can ANGPTL3 levels be modified through lifestyle changes? 11/08/2017

While lifestyle changes alone may not directly impact ANGPTL3 levels, they can influence lipid and glucose metabolism, which in turn can affect ANGPTL3 regulation. Healthy lifestyle choices, including regular exercise, a balanced diet, weight management, and avoidance of smoking, can contribute to improved lipid and glucose metabolism, potentially leading to healthier ANGPTL3 levels.

Are there any side effects associated with ANGPTL3-targeted therapies? 09/13/2017

Clinical trials have shown that ANGPTL3-targeted therapies have generally been well-tolerated, with few reported side effects. However, long-term safety data are still limited, and further research is needed to understand any potential side effects.

Can ANGPTL3 levels be influenced by lifestyle or diet? 07/28/2017

Yes, studies have shown that lifestyle factors such as diet and exercise can influence ANGPTL3 levels. A high-sugar diet and sedentary behavior have been associated with higher ANGPTL3 levels, while a healthy, balanced diet and regular physical activity may help normalize its levels.

Are there any specific populations that may benefit more from ANGPTL3-targeted therapies? 06/01/2017

ANGPTL3-targeted therapies may be particularly beneficial for individuals with genetically determined high cholesterol levels, such as those with familial hypercholesterolemia. They may also be helpful for individuals who do not respond well to or cannot tolerate traditional cholesterol-lowering medications. However, further research is needed to identify specific populations that may benefit the most from these therapies.

Are there any drug therapies targeting ANGPTL3? 05/16/2017

Yes, there are drug therapies being developed that target ANGPTL3. These therapeutic approaches aim to inhibit the activity of ANGPTL3 to reduce LDL cholesterol and triglyceride levels in individuals with hyperlipidemia or other related conditions.

Are ANGPTL3-targeted therapies approved for widespread use? 04/19/2017

No, ANGPTL3-targeted therapies are still under development and have not yet received regulatory approval for widespread use. Further research is needed to determine their long-term effectiveness and safety profile.

Are there any dietary or lifestyle changes that can naturally lower ANGPTL3 levels? 04/14/2017

While there is no specific dietary or lifestyle change that can directly lower ANGPTL3 levels, adopting a healthy lifestyle can indirectly help maintain balanced lipid metabolism. Regular physical activity, a balanced diet rich in fruits, vegetables, and whole grains, and avoiding excessive consumption of added sugars and unhealthy fats can benefit overall heart health and lipid profile, including LDL cholesterol and triglyceride levels.

Can ANGPTL3 deficiency be beneficial? 11/07/2016

Yes, ANGPTL3 deficiency has been associated with certain health benefits. Individuals with genetic mutations causing low or absent ANGPTL3 production have been found to have reduced risk of cardiovascular disease, lower LDL cholesterol, lower triglycerides, and higher HDL cholesterol levels. However, further research is needed to fully understand the potential benefits and any potential side effects of ANGPTL3 deficiency.

Besides lipid metabolism, does ANGPTL3 have any other functions? 11/05/2016

ANGPTL3 has been found to have additional roles beyond lipid metabolism. It has been implicated in angiogenesis (the formation of new blood vessels) and in regulating glucose metabolism.

What happens if ANGPTL3 levels are elevated? 10/13/2016

Elevated levels of ANGPTL3 can result in decreased LPL activity, leading to increased levels of triglycerides and LDL cholesterol in the bloodstream.

Are there any genetic mutations associated with ANGPTL3? 09/10/2016

Yes, genetic mutations that cause ANGPTL3 deficiency or loss-of-function have been associated with lower levels of LDL cholesterol and triglycerides.

Are there any ANGPTL3-targeted therapies currently approved for use? 08/20/2016

Yes, there are approved ANGPTL3-targeted therapies available. One example is evinacumab, which was approved by the U.S. Food and Drug Administration (FDA) in February 2021 for the treatment of homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder characterized by extremely high cholesterol levels. Evinacumab is an antibody that targets and inhibits ANGPTL3, leading to decreased LDL cholesterol levels.

What are the limitations or challenges associated with ANGPTL3-targeted therapies? 05/28/2016

One limitation of ANGPTL3-targeted therapies is the high cost, as they are currently expensive medications. This can limit their accessibility and affordability for some individuals. Additionally, long-term safety data are still limited, and potential side effects or interactions with other medications need to be further explored.

Customer Reviews (5)

Write a review
Reviews
04/04/2021

    One of the standout advantages offered by the manufacturer is their excellent technical support.

    10/10/2018

      The ANGPTL3 protein is of exceptional quality, meeting all my experimental requirements with precision and reliability.

      09/29/2018

        They continuously stay up-to-date with the latest scientific advancements and customer feedback, allowing them to refine the ANGPTL3 protein based on emerging trends.

        09/27/2017

          This exceptional level of support enables me to overcome challenges efficiently and progress smoothly with my research.

          05/05/2016

            They provide comprehensive assistance, ensuring that any queries or concerns I have regarding the ANGPTL3 protein are promptly addressed.

            Ask a Question for All ANGPTL3 Products

            Required fields are marked with *

            My Review for All ANGPTL3 Products

            Required fields are marked with *

            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends