angptl4
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  • Official Full Name
  • ANGPTL4 angiopoietin-like 4
  • Background
  • Angiopoietin-like protein 4 (ANGPTL4), also known as PPARĪ³ angiopoietinrelated protein, fastinginduced adipose factor, or hepatic fibrinogen /angiopoietin-related protein (HFARP), is a secreted adipokine predominantly expressed in adipose tissue and liver. The experimental results show that ANGPTL4 is a blood-borne hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. Serum levels of ANGPTL4 were decreased in patients with type 2 diabetes. In animal experiments, ANGPTL4 treatments might reduce hyperglycemia, and improve glucose tolerance by decreasing hepatic glucose production and enhancing insulin-mediated inhibition of gluconeogenesis. However, the molecular mechanisms underlying its metabolic actions remain elusive.
  • Synonyms
  • ANGPTL4; angiopoietin-like 4; angiopoietin-related protein 4; angiopoietin related protein 4; ARP4; fasting induced adipose factor; FIAF; hepatic angiopoietin related protein; hepatic fibrinogen/angiopoietin related protein; HFARP; NL2; peroxisome proliferator activated receptor (PPAR) gamma induced angiopoietin related protein; PGAR; pp1158; PPARG angiopoietin related protein; angiopoietin-like protein 4; fasting-induced adipose factor; hepatic angiopoietin-related protein; hepatic fibrinogen/angiopoietin-related protein; peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein; ANGPTL2;
Cat.#:ANGPTL4-102HTag:FLAG
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPTL4 Protein, FLAG-tagged
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Cat.#:ANGPTL4-159HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ANGPTL4 Protein, His-tagged, Biotinylated
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Cat.#:ANGPTL4-160HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ANGPTL4 Protein, His-tagged, Biotinylated
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Cat.#:ANGPTL4-231HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPTL4 Protein, Fc-tagged
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Cat.#:ANGPTL4-268HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ANGPTL4 protein, His-tagged
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Cat.#:ANGPTL4-26HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ANGPTL4, His-tagged
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Cat.#:ANGPTL4-27HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ANGPTL4, GST-tagged
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Cat.#:ANGPTL4-430HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPTL4, His tagged
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Cat.#:ANGPTL4-495HTag:His|DDK
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ANGPTL4 Protein, His/DDK-tagged
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Cat.#:ANGPTL4-496HTag:DDK|His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ANGPTL4 Protein, DDK/His-tagged
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Cat.#:ANGPTL4-557HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ANGPTL4 protein, GST-tagged
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Cat.#:ANGPTL4-5742HTag:His|GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPTL4 protein, His & GST-tagged
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Cat.#:ANGPTL4-98HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPTL4, FLAG-tagged
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Cat.#:Angptl4-101MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Angptl4, FLAG-tagged
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Cat.#:Angptl4-105MTag:Flag
Source (Host):COS-7Species:Mouse
Product nameRecombinant Mouse Angptl4, FLAG-tagged
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Cat.#:Angptl4-476MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Angptl4, His-tagged
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Cat.#:Angptl4-5743MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Angptl4 protein, His-tagged
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Cat.#:Angptl4-102RTag:Flag
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Angptl4, FLAG-tagged
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Cat.#:Angptl4-104RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Angptl4, His-tagged
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Cat.#:Angptl4-5745RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Angptl4 protein, His & T7-tagged
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Cat.#:ANGPTL4-670RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ANGPTL4 Protein
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Cat.#:ANGPTL4-8125ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ANGPTL4
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Cat.#:ANGPTL4-5741CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle ANGPTL4 protein, His-tagged
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Cat.#:ANGPTL4-5744PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig ANGPTL4 protein, His-tagged
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Cat.#:ANGPTL4-118HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Angiopoietin-like 4, His-tagged
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Cat.#:ANGPTL4-403HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPTL4, Fibrinogen-like Domain, FLAG-tagged
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Cat.#:ANGPTL4-404HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Angiopoietin-like 4, His-tagged
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Cat.#:ANGPTL4-497HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANGPTL4, His-tagged
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Cat.#:ANGPTL4-402MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Angiopoietin-like 4, Coiled-Coil Domain, His-tagged
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Cat.#:Angptl4-405MTag:Flag
Source (Host):COS-7Species:Mouse
Product nameRecombinant Mouse Angiopoietin-like 4, FLAG-tagged
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Cat.#:Angptl4-406MTag:N/A
Source (Host):Species:Mouse
Product nameRecombinant Mouse Angptl4, His-tagged
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Cat.#:ANGPTL4-1097HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ANGPTL4 cell lysate
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Cat.#:ANGPTL4-746MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ANGPTL4 cell lysate
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Involved Pathway

ANGPTL4 involved in several pathways and played different roles in them. We selected most pathways ANGPTL4 participated on our site, such as PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPTL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PPAR signaling pathway
ADIPOQB; RXRGA; CD36; CYP4A14; LPL; APOA1; RXRG; SCD5; ACSL1A; SLC27A1A

Protein Function

ANGPTL4 has several biochemical functions, for example, enzyme inhibitor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPTL4 itself. We selected most functions ANGPTL4 had, and list some proteins which have the same functions with ANGPTL4. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme inhibitor activity
Related Protein WDTC1; GCHFR; CD46; TAE1; SLN; UGT1A9; SCG5; UGT1A7; PDE6H; OAZ2A
Function protein binding
Related Protein MOAP1; SLC25A23; PHB2; TTC1; RAB23; IL13RA1; TMEM182; PIWIL1; MCM4; SPINK1

Interacting Protein

ANGPTL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPTL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPTL4.
ITGB5; ITGB1; AURKA; TGFB1; ESR1; FGFR4; CDKN2A; CDKN2C; CASP8; FBXW7; BRMS1; RAC1; PTK2