atp7b
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  • Official Full Name
  • ATPase, Cu++ transporting, beta polypeptide
  • Background
  • This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
  • Synonyms
  • ATP7B; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (Wilson disease) , WND; copper-transporting ATPase 2; Wilson disease; copper pump 2; Wilson disease-associated protein; ATPase, Cu(2+)- transporting, beta poly
Cat.#:ATP7B-467HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP7B Protein, His-tagged
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Cat.#:ATP7B-1014HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATP7B protein, GST-tagged
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Cat.#:ATP7B-2172MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATP7B Protein
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Cat.#:ATP7B-174HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATP7B
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Cat.#:ATP7B-8572HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ATP7B 293 Cell Lysate
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Involved Pathway

ATP7B involved in several pathways and played different roles in them. We selected most pathways ATP7B participated on our site, such as Ion channel transport, Ion transport by P-type ATPases, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ion channel transport
FXYD7; TRPC4A; ANO10A; TRPC4APB; SLC9A10; ATP1A1A.5; SLC17A3; CLCN6; ATP1A1A.3; WNK2
Ion transport by P-type ATPases
ATP13A; ATP1A1A.4; FXYD3; FXYD6-FXYD2; CCC2; ATP2B1B; ATP2B3A; ATP2C2; ATP13A1; ATP1A1A.5
Transmembrane transport of small molecules
SLC2A15B; AQP11; ATP13A; MIPB; SLC26A3; ATP7B; SLC15A1B; FTH1B; ANO5; SLC9A3.1

Protein Function

ATP7B has several biochemical functions, for example, ATP binding, copper ion binding, copper-exporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP7B itself. We selected most functions ATP7B had, and list some proteins which have the same functions with ATP7B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RUVBL2; CAMK2B1; IPPK; NMNAT3; CLP1; SKIV2L; ABCD3A; FICD; NLRP4; PRKCQ
Function copper ion binding
Related Protein LOXL3B; S100A5; CCS; MOXD1L; PAM; DCT; CP; P2RX2; SNCA; LOXL5B
Function copper-exporting ATPase activity
Related Protein ATP7B; ATP7A
Function protein binding
Related Protein HPN; CEP70; ZMYND19; EVC2; MRPL27; ZFP335; ADIPOQ; IMPDH2; CALCA; 2610109H07Rik

ATP7B Related Articles

Palm-Espling, ME; Lundin, C; et al. Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells. PROTEIN AND PEPTIDE LETTERS 21:63-68(2014).
Valtorta, S; Belloli, S; et al. Comparison of F-18-Fluoroazomycin-Arabinofuranoside and Cu-64-Diacetyl-Bis(N4-Methylthiosemicarbazone) in Preclinical Models of Cancer. JOURNAL OF NUCLEAR MEDICINE 54:1106-1112(2013).