ATP7B Protein, ATPase, Cu++ transporting, beta polypeptide

ATP7B

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ATP7B

Official Full Name ATPase, Cu++ transporting, beta polypeptide
Background This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).
Synonyms ATP7B; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (Wilson disease) , WND; copper-transporting ATPase 2; Wilson disease; copper pump 2; Wilson disease-associated protein; ATPase, Cu(2+)- transporting, beta poly
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP7B-468H Recombinant Human ATP7B Protein, Myc/ddk-tagged HEK293T Myc/DDK
    Mouse Atp7b-676M Recombinant Mouse Atp7b Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ATP7B-1014H Recombinant Human ATP7B protein, GST-tagged Wheat Germ GST
    Human ATP7B-174H Recombinant Human ATP7B E.coli N/A
    Human ATP7B-467H Recombinant Human ATP7B Protein, His-tagged E.coli His
    Human ATP7B-8572HCL Recombinant Human ATP7B 293 Cell Lysate HEK293 N/A
    Mouse ATP7B-2172M Recombinant Mouse ATP7B Protein Mammalian Cell His

    ATP7B involved in several pathways and played different roles in them. We selected most pathways ATP7B participated on our site, such as Ion channel transport, Ion transport by P-type ATPases, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport SLC9B2; SLC9A10; ANO10A; CLCN4-2; TSC22D3; FXYD7; Ano3; TRPM6; SRI; NHEDC1
    Ion transport by P-type ATPases ATP7B; ATP8B1; PDZD11; ATP1A1A.3; ATP1A1A.5; ATP1A1A.4; ATP13A5; CCC2; ATP1A1A.2; ATP13A
    Transmembrane transport of small molecules SLC29A4; SLC1A7B; AQP11; TRPM1A; ATP2B3A; RHCGL1; RHAG; NIPA1; CLCN4-2; CP

    ATP7B has several biochemical functions, for example, ATP binding, copper ion binding, copper-exporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP7B itself. We selected most functions ATP7B had, and list some proteins which have the same functions with ATP7B. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding EPHA4A; HSPA13; G3BP1; NTRK2; PMVK; HSPE1; TSSK4; ATP8A1; PRKACBA; EP400
    copper ion binding TYR; COX11; AOC1; PRNP; HAMP; S100A12; MOXD2; F5; ATP7B; PRNPA
    copper-exporting ATPase activity ATP7A; ATP7B
    protein binding ZC3H10; FBXO7; GPR85; GTSE1; GALNT2; WHSC1; NSMCE4A; PACSIN3; COPS3; BACE1

    ATP7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP7B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP7B.

    Palm-Espling, ME; Lundin, C; et al. Interaction between the Anticancer Drug Cisplatin and the Copper Chaperone Atox1 in Human Melanoma Cells. PROTEIN AND PEPTIDE LETTERS 21:63-68(2014).
    Valtorta, S; Belloli, S; et al. Comparison of F-18-Fluoroazomycin-Arabinofuranoside and Cu-64-Diacetyl-Bis(N4-Methylthiosemicarbazone) in Preclinical Models of Cancer. JOURNAL OF NUCLEAR MEDICINE 54:1106-1112(2013).

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