|Official Full Name||ATPase, Cu++ transporting, beta polypeptide|
|Background||This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).|
|Synonyms||ATP7B; ATPase, Cu++ transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (Wilson disease) , WND; copper-transporting ATPase 2; Wilson disease; copper pump 2; Wilson disease-associated protein; ATPase, Cu(2+)- transporting, beta poly|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ATP7B involved in several pathways and played different roles in them. We selected most pathways ATP7B participated on our site, such as Ion channel transport, Ion transport by P-type ATPases, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Ion channel transport||SLC9B2; SLC9A10; ANO10A; CLCN4-2; TSC22D3; FXYD7; Ano3; TRPM6; SRI; NHEDC1|
|Ion transport by P-type ATPases||ATP7B; ATP8B1; PDZD11; ATP1A1A.3; ATP1A1A.5; ATP1A1A.4; ATP13A5; CCC2; ATP1A1A.2; ATP13A|
|Transmembrane transport of small molecules||SLC29A4; SLC1A7B; AQP11; TRPM1A; ATP2B3A; RHCGL1; RHAG; NIPA1; CLCN4-2; CP|
ATP7B has several biochemical functions, for example, ATP binding, copper ion binding, copper-exporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP7B itself. We selected most functions ATP7B had, and list some proteins which have the same functions with ATP7B. You can find most of the proteins on our site.
|ATP binding||EPHA4A; HSPA13; G3BP1; NTRK2; PMVK; HSPE1; TSSK4; ATP8A1; PRKACBA; EP400|
|copper ion binding||TYR; COX11; AOC1; PRNP; HAMP; S100A12; MOXD2; F5; ATP7B; PRNPA|
|copper-exporting ATPase activity||ATP7A; ATP7B|
|protein binding||ZC3H10; FBXO7; GPR85; GTSE1; GALNT2; WHSC1; NSMCE4A; PACSIN3; COPS3; BACE1|
ATP7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP7B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP7B.