atg3
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  • Official Full Name
  • ATG3 autophagy related 3 homolog
  • Background
  • Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole. Human ATG3 displays;the same enzymatic characteristics in vitro as yeast Apg3, a protein-conjugating enzyme essential for autophagy;(Tanida et al., 2002 (PubMed 11825910)).
  • Synonyms
  • ATG3; ATG3 autophagy related 3 homolog (S. cerevisiae); APG3 autophagy 3 like (S. cerevisiae) , APG3L; ubiquitin-like-conjugating enzyme ATG3; DKFZp564M1178; FLJ22125; MGC15201; PC3 96; hApg3; 2610016C12Rik; autophagy-related protein 3; APG3; APG3L; PC3-9
Cat.#:APG3L-678HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APG3L protein, GST-tagged
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Cat.#:ATG3-222HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG3, His-tagged
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Cat.#:ATG3-35HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG3, His-tagged
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Cat.#:ATG3-744HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATG3 Protein, His-tagged
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Cat.#:ATG3-947HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATG3 protein, GST-tagged
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Cat.#:ATG3-2081MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ATG3 Protein
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Cat.#:ATG3-844RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATG3 Protein
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Cat.#:ATG3-440RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ATG3 Protein, His-tagged
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Cat.#:ATG3-5340CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATG3
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Cat.#:ATG3-10381ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ATG3
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Cat.#:ATG3-8625HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ATG3 293 Cell Lysate
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Involved Pathway

ATG3 involved in several pathways and played different roles in them. We selected most pathways ATG3 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Regulation of autophagy
ULK2; INS1; IFNA5; IFNA6; IFNA14; INSB; ATG4D; BECN1; Ifna11; IFNA3

Protein Function

ATG3 has several biochemical functions, for example, Atg12 transferase activity, Atg8 ligase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG3 itself. We selected most functions ATG3 had, and list some proteins which have the same functions with ATG3. You can find most of the proteins on our site.
Function
Related Protein
Function Atg12 transferase activity
Related Protein ATG10; ATG3
Function Atg8 ligase activity
Related Protein ATG3; ATG12
Function enzyme binding
Related Protein MLEC; PTPLAD2; Ar; EGLN1; UGT1A6; LAMP1; YWHAE; HSPA5; ACAT1; PARK7
Function ligase activity
Related Protein TRIM56; DTX4; RNF212; CCNB1IP1; RNF133; UBR3; RNF114; RANBP2; NEDD4; PRPF19
Function protein binding
Related Protein PPP3CB; ZMAT3; MID2; SIPA1L2; MS4A1; CHRD; FAM212A; SH3GL2; AMY1B; G0S2
Function ubiquitin-like protein transferase activity
Related Protein UBL4A; RNF139; RNF14; ARIH1; ATG3; ATG16L1

Interacting Protein

ATG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG3.
GABARAPL2; MAP1LC3B; GABARAP; ATG12

ATG3 Related Articles

Kamat, PK; Kalani, A; et al. Hydrogen Sulfide Epigenetically Attenuates Homocysteine-Induced Mitochondrial Toxicity Mediated Through NMDA Receptor in Mouse Brain Endothelial (bEnd3) Cells. JOURNAL OF CELLULAR PHYSIOLOGY 230:378-394(2015).
Akl, MR; Ayoub, NM; et al. Araguspongine C Induces Autophagic Death in Breast Cancer Cells through Suppression of c-Met and HER2 Receptor Tyrosine Kinase Signaling. MARINE DRUGS 13:288-311(2015).