Mouse Anti-Atg3 Monoclonal Antibody

• Cat.No.: DMABT-H17736
• Product Overview: Mouse Anti-Atg3 Monoclonal Antibody

Specification

• Species: Human
• Source: Mouse
• Tag: Non
• Antigen Description: Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Microtubule-associated protein light chain4(LC3) is a homologue of yeast Atg8, an essential component of autophagy. Following synthesis, the C-terminus of LC3 is cleaved by a cysteine protease-Atg4, to produce LC3-I, which is located in cytosolic fraction. LC3-I is activated by the E1-like enzyme Atg7 and forms a Atg7-LC3-I thioester. Atg7-LC3-I is transferred to Atg3 to form Atg3-LC3-I thioester. Atg3 is an E2-like enzyme that catalyzes the conjugation of LC3-I and phosphatidylethanolamine (PE) to form LC3-II. The LC3-II-PE conjugate is essential for binding tightly to autophagosomal membrane.
• Target: Atg3
• Isotype: IgG2b
• species: Human
• Clone: 4F9
• Conjugation: N/A
• Applications: WB,IP,ICC,IHC,Flow Cyt
• Storage: -20°C
• Size: 100 μg
• Ship: 4°C

Gene Information

• Gene Name: ATG3 ATG3 autophagy related4homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: Atg3
• Synonyms: ATG3; ATG3 autophagy related4homolog (S. cerevisiae); APG3 autophagy4like (S. cerevisiae) , APG3L; ubiquitin-like-conjugating enzyme ATG3; DKFZp564M1178; FLJ22125; MGC15201; PC3 96; hApg3; 2610016C12Rik; autophagy-related protein 3; APG3; APG3L; PC3-96; APG3-LIKE
• Gene ID: 64422
• mRNA Refseq: NM_022488
• Protein Refseq: NP_071933
• MIM: 609606
• UniProt ID: Q9NT62
• Chromosome Location: 3q13.2
• Pathway: Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem
• Function: Atg12 ligase activity; Atg8 ligase activity; enzyme binding; ligase activity; protein binding; small conjugating protein ligase activity