bcl6
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  • Official Full Name
  • B-cell CLL/lymphoma 6
  • Background
  • The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
  • Synonyms
  • BCL6; B-cell CLL/lymphoma 6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; B-cell lymphoma 6 protein; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3;
Cat.#:BCL6-10185HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL6, GST-tagged
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Cat.#:BCL6-158HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL6 Protein
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Cat.#:BCL6-159HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BCL6 Protein
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Cat.#:BCL6-252HTag:His/Trx
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL6, His & Trx-tagged
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Cat.#:BCL6-26735THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BCL6 Protein, GST-tagged
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Cat.#:BCL6-2351MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BCL6 Protein
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Cat.#:BCL6-524RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey BCL6 Protein, His-tagged
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Cat.#:BCL6-2143CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BCL6
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Cat.#:BCL6-148HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human B-cell CLL/lymphoma 6
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Cat.#:BCL6-8479HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BCL6 293 Cell Lysate
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Involved Pathway

BCL6 involved in several pathways and played different roles in them. We selected most pathways BCL6 participated on our site, such as FoxO signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
G6PCA.2; CCND2A; FOXO1B; GRB2A; SOS1; SMAD2; MAP2K2B; PIK3CG; CDKN1BB; AKT1
Transcriptional misregulation in cancer
CLSTN2; NCOR1; HOXA11; IL1R2; IGF1; CCND2; SMAD1; SUPT3H; GRIA3; SS18

Protein Function

BCL6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL6 itself. We selected most functions BCL6 had, and list some proteins which have the same functions with BCL6. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein GATA2; ALX1; BARX2; IKZF5; ZNF8; RUNX3; ZNF691; PHOX2B; PHF21A; GATA5
Function chromatin DNA binding
Related Protein WBP2; NOTCH1; FOXO3; NKAP; GRHL3; H1F0; H2AFY2; SMAD3; HDAC3; EP300
Function chromatin binding
Related Protein DNMT1; CHAF1B; GATA3; PHF21B; TP63; SOX10; GATA2B; SUV39H1; RBMX; TFAM
Function intronic transcription regulatory region sequence-specific DNA binding
Related Protein NKX2-1; BCL6; GRHL2
Function metal ion binding
Related Protein ZNF823; PAPD7; PLA2G4AA; NEK5; ZNF19; DYTN; AEBP2; XRCC6BP1; GGTA1; HELZ2
Function protein binding
Related Protein AP4M1; HER11; MAST2; TRMT2B; HOOK3; ID2; ROPN1B; HTR3A; TCHP; TBX24
Function sequence-specific DNA binding
Related Protein DLX5A; SPIB; HOXC6A; FOXG1C; HOXB3A; ZFP42; MEOX2; POU2F1A; HOXB10A; MSXA
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF821; TFDP1; NFE2L3; EGR1; ZNF157; SMAD3; NPAS1; SPI1; NFE2L2A; MAFBA
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein KLF6A; MITF; HOXD9; ETV3; SATB1; ZNF350; ASCL3; ARID5B; E2F7; POU5F1

Interacting Protein

BCL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL6.
BCL6B; ZBTB7B; LIMS3L; AES; TRAF1; SIAH1; KIFC3

BCL6 Related Articles

Basso, K; Dalla-Favera, R; et al. Germinal centres and B cell lymphomagenesis. NATURE REVIEWS IMMUNOLOGY 15:172-184(2015).
Gao, FJ; Yang, YY; et al. BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-kappa B activation. CELLULAR IMMUNOLOGY 294:1-8(2015).

BCL6 Related Gene Family

BCL2 Gene Family