BCL6
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Official Full Name
B-cell CLL/lymphoma 6
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Overview
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008] -
Synonyms
BCL6; B-cell CLL/lymphoma 6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; B-cell lymphoma 6 protein; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|Trx
- SUMO
- MYC
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- BCL6 Related Signal Pathway
BCL6 involved in several pathways and played different roles in them. We selected most pathways BCL6 participated on our site, such as FoxO signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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FoxO signaling pathway | SGK2;FASLG;PTEN;GADD45AB;SETD7;HRASB;PLK2;SKP2;PLK1 |
Transcriptional misregulation in cancer | MLLT3;MAX;KDM6A;TAF15;PAX8;ID2;MEIS1;CCNA1;CCNT2 |
BCL6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL6 itself. We selected most functions BCL6 had, and list some proteins which have the same functions with BCL6. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II regulatory region sequence-specific DNA binding | ZSCAN2;ETV5;NHLH2;ZGLP1;ZNF773;IKZF5;CSDA;JARID2;OSR2 |
chromatin DNA binding | HIST1H1C;CLOCK;APEX1;NOTCH1;WBP2;HDAC3;EP300;MYOG;HIST1H1B |
chromatin binding | PBRM1;CSNK2B;KLF14;YBX1;SIN3A;ORC1L;TP53;ESR1;PPARGC1A |
intronic transcription regulatory region sequence-specific DNA binding | BCL6;NKX2-1;GRHL2 |
metal ion binding | NUDT1;TDO2A;SLC8A1;JMJD5;PDE6B;GUCA1D;EGR2;RTCB;VEPH1 |
protein binding | SASS6;CRABP2;PID1;THBD;PTK6;RAD9B;SPTAN1;ZFP488;ARF6 |
sequence-specific DNA binding | MNX1;ATF5A;DLX2B;NEUROG2;LHX8A;ATF5;SIX4B;CAMTA2;HOXB9A |
transcription factor activity, sequence-specific DNA binding | HSFX1;FOXO3B;ARNTL1B;FUBP1;ZFP583;TRIM29;NFATC1;HIF1AL;ZBTB11 |
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | NR2F6;HIST2H3A;ETV6;FERD3L;CGGBP1;MITF;VAX1;ZEB1;HOXD9 |
BCL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL6.
BCL6B; ZBTB7B; LIMS3L; AES; TRAF1; SIAH1; KIFC3
Gene Family
Research Area
Related articles
- Q&As
- Reviews
Q&As (5)
Ask a questionChallenges include the need to develop specific and effective inhibitors of BCL6 function while minimizing off-target effects and ensuring tolerability in clinical settings.
Yes, genetic mutations and translocations involving the BCL6 gene have been linked to the development of certain lymphomas and other hematological malignancies.
BCL6 protein is crucial for the formation and maintenance of germinal centers, where it regulates the processes of somatic hypermutation and class-switch recombination in B cells.
Targeting BCL6 protein could potentially offer new therapeutic options by modulating immune responses and suppressing the aberrant production of autoantibodies in autoimmune diseases.
Yes, the assessment of BCL6 protein expression can provide valuable prognostic information, helping to predict patient outcomes and guide treatment strategies for lymphoma patients.
Customer Reviews (3)
Write a reviewIts stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.
I am delighted to highly recommend the BCL6 Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis
Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.
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