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BCL6

  • Official Full Name

    B-cell CLL/lymphoma 6

  • Overview

    The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
  • Synonyms

    BCL6; B-cell CLL/lymphoma 6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; B-cell lymphoma 6 protein; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Trx
  • SUMO
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human BCL6-148H Recombinant Human B-cell CLL/lymphoma 6 E.coli His
Human BCL6-252H Recombinant Human BCL6, His & Trx-tagged E.coli His/Trx
Human BCL6-26735TH Recombinant Human BCL6 Protein, GST-tagged E.coli GST
Human BCL6-10185H Recombinant Human BCL6, GST-tagged E.coli GST 183-532a.a.
Human BCL6-158H Recombinant Human BCL6 Protein, GST-tagged E.coli GST
Human BCL6-159H Recombinant Human BCL6 Protein Wheat Germ GST
Human BCL6-8479HCL Recombinant Human BCL6 293 Cell Lysate HEK293 N/A
Human BCL6-2583H Recombinant Human BCL6 protein, GST-tagged E.coli GST 1-706aa
Human BCL6-306H Recombinant Human BCL6 Protein, His-tagged E.coli N-His Met1-Tyr408
Human BCL6-81H Recombinant Human BCL6 protein E.coli N/A 1-706aa
Human BCL6-305HFL Recombinant Full Length Human BCL6 Protein, C-Flag-tagged Mammalian cells Flag
Human BCL6-2584H Recombinant Human BCL6 protein, His-SUMO-tagged E.coli His-SUMO 1-418aa
Human BCL6-1362H Recombinant Human BCL6 protein, His-tagged E.coli His 1-706aa
Human BCL6-441H Recombinant Human BCL6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human BCL6-441H-B Recombinant Human BCL6 Protein Pre-coupled Magnetic Beads HEK293
Mouse BCL6-2351M Recombinant Mouse BCL6 Protein Mammalian Cell His
Mouse BCL6-996M Recombinant Mouse BCL6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Bcl6-701M Recombinant Mouse Bcl6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse BCL6-996M-B Recombinant Mouse BCL6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BCL6-524R Recombinant Rhesus monkey BCL6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque BCL6-352R-B Recombinant Rhesus Macaque BCL6 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque BCL6-352R Recombinant Rhesus Macaque BCL6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken BCL6-2143C Recombinant Chicken BCL6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • BCL6 Related Articles
  • BCL6 Related Gene Family
  • BCL6 Related Research Area
  • BCL6 Related Signal Pathway

BCL6 involved in several pathways and played different roles in them. We selected most pathways BCL6 participated on our site, such as FoxO signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayHOMER3;HOMER1B;SKP2;NRAS;PIK3R3;TGFB1A;GRB2B;CCNB1;CDKN2D
Transcriptional misregulation in cancerBcl2a1b;ARNT2;TGFBR2;MAX;IL6;H3F3C;CD40;SMAD1;SPI1

BCL6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL6 itself. We selected most functions BCL6 had, and list some proteins which have the same functions with BCL6. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingSP3;CUX2;ZFY2;ZNF8;BHLHA15;ZFAT;HMX1;ZNF480;EOMES
chromatin DNA bindingATOH1;HIST1H1B;RARA;INSM1A;SLAMF7;INSM1B;HIST1H1A;THRA;NKAP
chromatin bindingSKIL;UPF1;CHD8;GATA3;NEUROD1;NCAPD2;SSBP1;NONO;SMARCC1
intronic transcription regulatory region sequence-specific DNA bindingGRHL2;BCL6;NKX2-1
metal ion bindingGPR39;AMPD3;WDFY3;TRIM35-31;SIRT4;ZC2HC1A;NR6A1B;SLC2A4RG;ZNF625
protein bindingUBL4A;NTF4;CLCF1;PACSIN2;EPB41L3;TXNDC16;NKD2;KCNK16;PIK3R6
sequence-specific DNA bindingRXRA;CREB3L3A;FOXG1;POU2F1;CUX1;NEUROG2;ZIC3;NKX2-6;IRX4
transcription factor activity, sequence-specific DNA bindingGATAD2A;ZNF490;FOXN1;ZNF354A;ZNF19;GCM2;NFATC2;TAF1B;PRDM1A
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingZNF350;HIST2H3A;GLIS1;FOXD3;ARHGAP35;CDX2;MSX1;VAX1;BCL6

BCL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL6.

BCL6B; ZBTB7B; LIMS3L; AES; TRAF1; SIAH1; KIFC3

Basso, K; Dalla-Favera, R; et al. Germinal centres and B cell lymphomagenesis. NATURE REVIEWS IMMUNOLOGY 15:172-184(2015).
Gao, FJ; Yang, YY; et al. BRAD4 plays a critical role in germinal center response by regulating Bcl-6 and NF-kappa B activation. CELLULAR IMMUNOLOGY 294:1-8(2015).
  • Q&As
  • Reviews

Q&As (5)

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What are the current challenges in targeting BCL6 protein for therapeutic purposes? 02/21/2023

Challenges include the need to develop specific and effective inhibitors of BCL6 function while minimizing off-target effects and ensuring tolerability in clinical settings.

Are there any known genetic mutations or alterations in the BCL6 gene associated with disease susceptibility? 10/07/2022

Yes, genetic mutations and translocations involving the BCL6 gene have been linked to the development of certain lymphomas and other hematological malignancies.

What role does BCL6 protein play in the germinal center reaction? 06/13/2022

BCL6 protein is crucial for the formation and maintenance of germinal centers, where it regulates the processes of somatic hypermutation and class-switch recombination in B cells.

How might targeting BCL6 protein offer new therapeutic options for autoimmune diseases? 06/30/2021

Targeting BCL6 protein could potentially offer new therapeutic options by modulating immune responses and suppressing the aberrant production of autoantibodies in autoimmune diseases.

Can the assessment of BCL6 protein expression aid in the prognosis of lymphoma patients? 05/22/2017

Yes, the assessment of BCL6 protein expression can provide valuable prognostic information, helping to predict patient outcomes and guide treatment strategies for lymphoma patients.

Customer Reviews (3)

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Reviews
04/21/2022

    Its stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.

    09/22/2021

      I am delighted to highly recommend the BCL6 Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis

      12/11/2016

        Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.

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