CADM1
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Official Full Name
cell adhesion molecule 1
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Overview
Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene. -
Synonyms
CADM1; cell adhesion molecule 1; IGSF4, immunoglobulin superfamily, member 4 , TSLC1, tumor suppressor in lung cancer 1; BL2; IGSF4A; Necl 2; NECL2; nectin like 2; RA175; ST17; SYNCAM; SYNCAM1; CADM1_HUMAN; DKFZp686F1789; IgSF4; Immunoglobulin superfamily member 4; MGC149785; MGC51880; NECL-2; Nectin-like protein 2; SgIGSF; Spermatogenic immunoglobulin superfamily; sTSLC 1; Synaptic cell adhesion molecule; TSLC-1; TSLC1; Tumor suppressor in lung cancer 1; nectin-like 2; TSLC1/Nectin-like 2/IGSF4; immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4D variant 2; sTSLC-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Fc
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CADM1 Related Articles
- CADM1 Related Research Area
CADM1 involved in several pathways and played different roles in them. We selected most pathways CADM1 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CADM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell adhesion molecules (CAMs) | CDH5;ITGA8;CLDN15LB;CD28;CD40;ITGB1B.2;CLDNJ;ITGB7;MHC2A |
CADM1 has several biochemical functions, for example, PDZ domain binding, cell adhesion molecule binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CADM1 itself. We selected most functions CADM1 had, and list some proteins which have the same functions with CADM1. You can find most of the proteins on our site.
Function | Related Protein |
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PDZ domain binding | F11R;PARK2;FZD7;ACOX1;GRIA1;FZD1;ERC1;ARHGEF16;GRM7 |
cell adhesion molecule binding | ITGAL;PVRL1A;PTBP3;GLYCAM1;AMICA1;POSTN;CD1D;JUP;PVRL3B |
protein binding | TTC8;CCND2;EZR;PRKX;PPP1R12C;IRAK1BP1;KNG1;Raet1a;CHAMP1 |
protein homodimerization activity | CD226;LRP6;TYMS;XDH;CAMK2B;NKX2;NR6A1A;BCL2A1;PSMD7 |
receptor activity | CD4;EIF2D;LILRB2;CD7;AMFR;ITGB3B;NOTCH4;ITGB1A;TLR4 |
receptor binding | HMGCL;PICK1;ADIPOQ;TMEM38A;PTK2;CLCF1;APLN;ICAM3;CSNK2B |
CADM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CADM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CADM1.
PSMA6; ATF7IP; LIN7A; EPB41L3; ITGB4
- Q&As
- Reviews
Q&As (5)
Ask a questionMutations or genetic variations in CADM1 can lead to altered protein function, potentially contributing to the development of diseases like autism spectrum disorders and various cancers. Studying these variations helps uncover their specific roles in disease progression.
CADM1 is a cell adhesion molecule that plays a crucial role in maintaining tissue integrity and mediating cell-cell adhesion. It is involved in various cellular processes, including tissue development, immune response, and neural cell connectivity.
Post-translational modifications of CADM1, such as phosphorylation and glycosylation, play critical roles in modulating its interactions and functions. Understanding these modifications is important for unraveling disease mechanisms and potential therapeutic targets.
CADM1 mediates immune cell interactions and regulates immune responses. Dysregulation of CADM1 has been implicated in autoimmune diseases like multiple sclerosis, where it affects immune cell adhesion and migration.
Therapeutic strategies targeting CADM1 in cancer treatment include antibody-based therapies and small molecule inhibitors. Challenges include ensuring specificity and minimizing potential side effects, given the diverse roles of CADM1 in different tissues.
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