ccr7
Share
  • Official Full Name
  • chemokine (C-C motif) receptor 7
  • Background
  • The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
  • Synonyms
  • CCR7; chemokine (C-C motif) receptor 7; CMKBR7, EBI1; C-C chemokine receptor type 7; BLR2; CD197; CDw197; CCR-7; CC-CKR-7; C-C CKR-7; MIP-3 beta receptor; CC chemokine receptor 7; chemokine (C-C) receptor 7; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced G-protein coupled receptor; lymphocyte-specific G protein-coupled peptide receptor; epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; CMKBR7
Cat.#:CCR7-0696HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCR7 Protein
+Inquiry
Cat.#:CCR7-3045HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCR7 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:CCR7-471HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CCR7
+Inquiry
Cat.#:CCR7-379CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CCR7 Protein, His-tagged
+Inquiry
Cat.#:CCR7-710RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCR7 Protein, His-tagged
+Inquiry
Cat.#:CCR7-4223CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCR7
+Inquiry
Cat.#:CCR7-5705ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCR7
+Inquiry
Cat.#:Kit-0874Tag:
Source (Host):Species:
Product nameHPRT Assay Kit
+Inquiry
Cat.#:Kit-1050Tag:
Source (Host):Species:
Product nameFactor XIa Activity Assay Kit (Colorimetric)
+Inquiry
Cat.#:Kit-1159Tag:
Source (Host):Species:
Product nameCCR7 HEK 293 β-Arrestin GPCR Assay Kit
+Inquiry
Cat.#:Kit-1160Tag:
Source (Host):Species:
Product nameCCR7 CHO-K1 β-Arrestin GPCR Assay Kit
+Inquiry
Cat.#:Kit-1161Tag:
Source (Host):Species:
Product namecAMP CCR7 CHO-K1 GPCR Assay Kit
+Inquiry
Cat.#:Kit-0873Tag:
Source (Host):Species:
Product nameL-Ascorbate Assay Kit
+Inquiry
Cat.#:CSC-RG0207Tag:
Source (Host):Species:Human
Product nameHuman CCR7-FLAG Stable Cell Line-HEK293T
+Inquiry
Cat.#:CSC-RG0494Tag:
Source (Host):Species:Human
Product nameHuman CCR7/Gi Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-RG0634Tag:
Source (Host):Species:Human
Product nameHuman CCR7/Galpha16 Stable Cell Line-Chem-1
+Inquiry

Involved Pathway

CCR7 involved in several pathways and played different roles in them. We selected most pathways CCR7 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR7 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine receptors bind chemokines
CCR1; CCBP2; ACKR4; CX3CR1; CCL35.2; CCR9; CXCL11.8; CCR5; AMCF-II; CCR6
Chemokine signaling pathway
PREX1; GM13306; PLCB1; CCL3L1; GNG2; SHC1; VAV2; GSK3A; NFKBIA; XCR1
Class A/1 (Rhodopsin-like receptors)
GPR55A; OPN4; XK; CCL35.1; TAC3; APLN; TRH; CCR3; CCR8; NMUR1
Cytokine-cytokine receptor interaction
TNFSF13B; BMPR2; CCL18; TNFRSF13B; CRFB16; TGFB3; KITLGB; TGFB1A; PRP2; ACVR2B
G alpha (i) signalling events
RGS6; GPR18; OPN1LW1; CHRM2; OPN1MW2; SSTR5; S1PR5B; SSTR3; LPAR1; RGS7
GPCR downstream signaling
CRH; CCR6; PENKB; TAS2R13; RAMP3; S1PR1; GPR55A; TRH; RHOC; CCL27
GPCR ligand binding
CALCB; CCR1; CHRM4; AGTR2; NMBA; FPR-RS6; GPR31; OPN1LW; RAMP1; OXGR1A.1
GPCRs, Class A Rhodopsin-like
PTGDR2; RRH; GPR4; FPR-RS3; DRD4; CHRM4; GPR63; FFAR3; GPR32; CMKLR1

Protein Function

CCR7 has several biochemical functions, for example, C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, C-C motif chemokine 21 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR7 itself. We selected most functions CCR7 had, and list some proteins which have the same functions with CCR7. You can find most of the proteins on our site.
Function
Related Protein
Function C-C chemokine receptor activity
Related Protein CCR1L1; CCR8; CCR6; CCR5; CCR7; CCR3; CCR10; CCR1; CCR9; GPR75
Function C-C motif chemokine 19 receptor activity
Related Protein CCR7
Function C-C motif chemokine 21 receptor activity
Related Protein CCR7
Function G-protein coupled receptor activity
Related Protein TAAR12C; ADORA2AB; OPN1MW; OR51E2; TAAR15; OPN1MW4; OLFR497; GPR63; DRD2B; GNRHR3
Function chemokine (C-C motif) ligand 19 binding
Related Protein CCR7
Function chemokine (C-C motif) ligand 21 binding
Related Protein CCR7

CCR7 Related Articles

Jensen, SS; Hartling, HJ; et al. HIV-Specific ADCC Improves After Antiretroviral Therapy and Correlates With Normalization of the NK Cell Phenotype. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 68:103-111(2015).
Stepensky, P; Rensing-Ehl, A; et al. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. BLOOD 125:753-761(2015).

CCR7 Related Gene Family

Chemokines Cytokines