CCR7 Protein, chemokine (C-C motif) receptor 7

CCR7

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CCR7

Official Full Name chemokine (C-C motif) receptor 7
Background The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
Synonyms CCR7; chemokine (C-C motif) receptor 7; CMKBR7, EBI1; C-C chemokine receptor type 7; BLR2; CD197; CDw197; CCR-7; CC-CKR-7; C-C CKR-7; MIP-3 beta receptor; CC chemokine receptor 7; chemokine (C-C) receptor 7; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced G-protein coupled receptor; lymphocyte-specific G protein-coupled peptide receptor; epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; CMKBR7
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCR7-0696H Recombinant Human CCR7 Protein Wheat Germ N/A
    Human CCR7-3045H Recombinant Human CCR7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CCR7-471H Recombinant Human CCR7 Mammalian Cell His
    Cynomolgus Monkey CCR7-379C Recombinant Cynomolgus CCR7 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CCR7-710R Recombinant Rhesus monkey CCR7 Protein, His-tagged Mammalian Cell His
    Chicken CCR7-4223C Recombinant Chicken CCR7 Mammalian Cell His
    Zebrafish CCR7-5705Z Recombinant Zebrafish CCR7 Mammalian Cell His
    Kit-0874 HPRT Assay Kit N/A
    Kit-1050 Factor XIa Activity Assay Kit (Colorimetric) N/A
    Kit-1159 CCR7 HEK 293 β-Arrestin GPCR Assay Kit N/A
    Kit-1160 CCR7 CHO-K1 β-Arrestin GPCR Assay Kit N/A
    Kit-1161 cAMP CCR7 CHO-K1 GPCR Assay Kit N/A

    CCR7 involved in several pathways and played different roles in them. We selected most pathways CCR7 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine receptors bind chemokines CCR1; CCL19A.2; CCBP2; CCL35.1; CXCL13; CCR3; CCR8; AMCF-II; CCRL2; CCR5
    Chemokine signaling pathway CCL26; STAT1; GRK1; GNGT1; GRK5; MAPK1; PRKCZ; CXCL13; XCR1; CXCL9
    Class A/1 (Rhodopsin-like receptors) RLN3A; ADORA2A; NMB; APLN; OXER1; RGR; TRH; NTS; GPR31B; NMBA
    Cytokine-cytokine receptor interaction CXCL1; PDGFB; PRLRA; TNFRSF6B; TNFRSF9A; TNFRSF10D; GM-CSF; GDF5; TGFBR1B; PRP2
    G alpha (i) signalling events S1PR5B; AMCF-II; OPN1LW2; PNOCB; RGS12; FPR-RS4; OXGR1A.3; OXGR1A.1; GPR17; ANXA1
    GPCR downstream signaling ARHGAP4A; RASGRP2; RLN3; ECT2; RGS19; SOUL4; NET1; RAMP1; DRD4; ADM
    GPCR ligand binding GHRH; GNB5B; GPR31; SSTR5; GPR55; NMB; CCL19A.2; OPN4A; S1PR3; LPAR2A
    GPCRs, Class A Rhodopsin-like GPR6; OR10A5; FPR-RS3; RRH; GPR4; SSTR5; OPN1LW; GPR85; GPR77; GPR32

    CCR7 has several biochemical functions, for example, C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, C-C motif chemokine 21 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR7 itself. We selected most functions CCR7 had, and list some proteins which have the same functions with CCR7. You can find most of the proteins on our site.

    Function Related Protein
    C-C chemokine receptor activity CCR1; CCR7; CCR1L1; CCR6; CCR10; CCBP2; CCR3; CCR8; CCR5; GPR75
    C-C motif chemokine 19 receptor activity CCR7
    C-C motif chemokine 21 receptor activity CCR7
    G-protein coupled receptor activity HTR1D; GPR98; GPR183A; OPN1SW2; VALOPA; VMN1R43; TAS2R113; OR51B2; OLFCG1; FZD8B
    chemokine (C-C motif) ligand 19 binding CCR7
    chemokine (C-C motif) ligand 21 binding CCR7

    CCR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR7.

    Jensen, SS; Hartling, HJ; et al. HIV-Specific ADCC Improves After Antiretroviral Therapy and Correlates With Normalization of the NK Cell Phenotype. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 68:103-111(2015).
    Stepensky, P; Rensing-Ehl, A; et al. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. BLOOD 125:753-761(2015).

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