Recombinant Full Length Human CCR7 Protein, C-Flag-tagged

• Cat.No.: CCR7-875HFL
• Product Overview: Recombinant Full Length Human CCR7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 40.2 kDa
• AA Sequence: MDLGKPMKSVLVVALLVIFQVCLCQ DEVTDDYIGDNTTVDYTLFESLCSK KDVRNFKAWFLPIMYSIICF VGLLGNGLVVLTYIYFKRLKTMTDT YLLNLAVADILFLLTLPFWAYSAAK SWVFGVHFCKLIFAIYKMSF FSGMLLLLCISIDRYVAIVQAVSAH RHRARVLLISKLSCVGIWILATVLS IPELLYSDLQRSSSEQAMRC SLITEHVEAFITIQVAQMVIGFLVP LLAMSFCYLVIIRTLLQARNFERNK AIKVIIAVVVVFIVFQLPYN GVVLAQTVANFNITSSTCELSKQLN IAYDVTYSLACVRCCVNPFLYAFIG VKFRNDLFKLFKDLGCLSQE
  QLRQWSSCRHIRRSSMSVEAETTTT FSPTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction

Gene Information

• Gene Name: CCR7 C-C motif chemokine receptor 7 [ Homo sapiens (human) ]
• Official Symbol: CCR7
• Synonyms: BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7
• Gene ID: 1236
• mRNA Refseq: NM_001838.4
• Protein Refseq: NP_001829.1
• MIM: 600242
• UniProt ID: P32248