|Official Full Name||cyclin-dependent kinase 4|
|Background||The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]|
|Synonyms||CDK4; cyclin-dependent kinase 4; CMM3; PSK-J3; cell division protein kinase 4;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CDK4 involved in several pathways and played different roles in them. We selected most pathways CDK4 participated on our site, such as ATF-2 transcription factor network, B Cell Receptor Signaling Pathway, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ATF-2 transcription factor network||GADD45A; CREB1; POU2F1; CBFB; CDK4; DDIT3; ATF2; HRK; MAPK14; JUN|
|B Cell Receptor Signaling Pathway||cgr2b; MAPK1; PILRB; CR2; DUSP4; FCGR2B; PIK3CA; NRAS; CD22; DOK1|
|Bladder cancer||E2F3; MYC; MDM2; TRP53; IL-8; E2F1; EGF; MAPK3; ARAF; DAPK3|
|Calcineurin-regulated NFAT-dependent transcription in lymphocytes||EGR1; EGR3; CDK4; IKZF1; IRF4; CTLA4; DGKA; EGR2; POU2F1; JUNB|
|Cell Cycle||CDC14A; CEP63; WEE2; HIST3H2BB; UIMC1; MAD2L2; CDC14B; CCP110; ORC5; E2F4|
|Cell Cycle, Mitotic||FOXM1; CDK11A; DULLARD; E2F2; TUBGCP3; ENSAB; SKA2; MIS12; POLD3; PMF1|
|Cellular Senescence||UBN1; HIRA; SUZ12B; CBX8; KDM6B; RNF2; AGO1; KAT5; CABIN1; HIST2H3C|
CDK4 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK4 itself. We selected most functions CDK4 had, and list some proteins which have the same functions with CDK4. You can find most of the proteins on our site.
|ATP binding||SRX1; MAP2K2B; ADCY6; CHD7; UBE2J1; YTHDC2; CKMT1; DDX6; MCM2; EPHB1|
|cyclin binding||INCA1; CDK14; CDK4; PFTK1; CDK2; CDK13; CDK6; HDAC3; CDKN1A; USP2|
|cyclin-dependent protein serine/threonine kinase activity||CDK5R1; CDK3; NAT1; CDK19; CDK11A; CDK18; ICK; CDK13; CDK17; PFTK1|
|cyclin-dependent protein serine/threonine kinase regulator activity||CCNT2B; CKS1B; CCNT2A; CCNE1; CCNL1; CCNE2; CCNL2; CCND1; CCNY; FAM58A|
|protein binding||TPP1; TPD52L2; PITPNC1; AGBL4; CD74; CLU; IFIH1; RIBC2; CCDC146; TACC3|
|protein complex binding||RAN; PGAM5; ABI2; WRN; NOG; STK11; DRD1; ST13; LRP2; RELA|
CDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK4.