CDK4
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Official Full Name
cyclin-dependent kinase 4
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Overview
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
CDK4; cyclin-dependent kinase 4; CMM3; PSK-J3; cell division protein kinase 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- MYC
- Myc|DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- CDK4 Related Articles
- CDK4 Related Research Area
- CDK4 Related Signal Pathway
CDK4 involved in several pathways and played different roles in them. We selected most pathways CDK4 participated on our site, such as ATF-2 transcription factor network, B Cell Receptor Signaling Pathway, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ATF-2 transcription factor network | RUVBL2;KCNA3;JUN;POU2F1;CSRP2;ATF2;JDP2;DUSP5;CBFB |
B Cell Receptor Signaling Pathway | VAV2;PLCG2;RASGRP3;PDK2B;PIK3CB;PIK3R1;LAT2;CMTM3;NFATC1 |
Bladder cancer | KRAS;EGF;E2F2;RB1;DAPK3;MAPK1;MDM2;TYMP;MYC |
Calcineurin-regulated NFAT-dependent transcription in lymphocytes | EGR2;EGR3;JUNB;IKZF1;CDK4;POU2F1;IRF4;EGR4;DGKA |
Cell Cycle | ORC3L;WAPAL;GSK3AA;ODF2;DCTN2;DHFR;HDAC6;GOLGA2;NUP35 |
Cell Cycle, Mitotic | B9D2;CKAP5;ENSA;RANGAP1B;PMF1;CEP78;SPC25;CEP70;PIANP |
Cellular Senescence | E2F3;HIST1H1B;EP400;CABIN1;CDKN2C;PHC1;TINF2;RING1;TERF2IP |
CDK4 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK4 itself. We selected most functions CDK4 had, and list some proteins which have the same functions with CDK4. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | CDC34B;TIE1;PRPS1L1;STK10;NSFA;YARS2;UBE2M;CAMK2B;PDXK |
cyclin binding | CDK14;USP2;CDK12;CDK2;CDK4;CDK5RAP3;PTCH1;INCA1;CDK13 |
cyclin-dependent protein serine/threonine kinase activity | CDKL5;CDK7;CDK11B;CDK2;CDK14;CDK12;CDK4;CDK8;MAK |
cyclin-dependent protein serine/threonine kinase regulator activity | CCNL2;CCNK;CCNT1;CCNL1;CCNL1A;CCND1;CDK4;CCNE1;CKS2 |
protein binding | PSG5;MAST2;APOE;EPHA10;C22orf39;SELL;ACTR3;PPP2R3C;KCTD15 |
protein complex binding | Cel;NASP;Ctsl;MAPK8IP2;VAMP2;LZTFL1;UQCRC1;CYFIP1;SREBF1 |
CDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK4.
CCND1; CDKN2A
- Q&As
- Reviews
Q&As (5)
Ask a questionResistance to CDK4 inhibitors and the need for patient stratification are some of the challenges in using CDK4 as a therapeutic target.
Yes, CDK4 is a target for cancer therapy, and drugs that inhibit CDK4 have been developed for the treatment of specific cancers.
CDK4 is clinically relevant because it plays a crucial role in the development and progression of various cancers.
CDK4 overactivity is commonly associated with breast cancer, melanoma, and liposarcoma.
CDK4 can promote cell senescence, a state of irreversible growth arrest, which has implications in cancer therapy.
Customer Reviews (3)
Write a reviewWhether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the CDK4 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.
They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the CDK4 protein.
The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.
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