cdk4
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  • Official Full Name
  • cyclin-dependent kinase 4
  • Background
  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CDK4; cyclin-dependent kinase 4; CMM3; PSK-J3; cell division protein kinase 4;
Cat.#:CDK4/CCND1-633HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK4/CCND1, His-tagged
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Cat.#:CDK4/CCND3-275HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK4/CCND3, GST-tagged, Active
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Cat.#:CDK4-1011HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDK4 Protein, GST-Tagged
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Cat.#:CDK4-1015HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK4 Protein, GST-Tagged
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Cat.#:CDK4-1016HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human CDK4 Protein, His-Tagged
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Cat.#:CDK4-3139HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CDK4 Protein, MYC/DDK-tagged
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Cat.#:CDK4-11049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK4, GST-tagged
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Cat.#:CDK4-16HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK4, His-tagged
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Cat.#:CDK4-191HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK4 protein, T7-tagged
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Cat.#:CDK4-27905THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK4
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Cat.#:CDK4-31093THTag:
Source (Host):Species:Human
Product nameRecombinant Human Human CDK4
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Cat.#:CDK4-758HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK4, GST tagged
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Cat.#:CDK4-938HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDK4 protein, His/T7-tagged
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Cat.#:CDK4-3203MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDK4 Protein
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Cat.#:Cdk4-5846MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdk4 protein, His-tagged
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Cat.#:CDK4-1304RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CDK4 Protein
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Cat.#:CDK4-784RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDK4 Protein, His-tagged
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Cat.#:CDK4-4853ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CDK4
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Cat.#:CDK4-1000HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 4, GST-tagged
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Cat.#:CDK4-7156HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase 4, His-tagged
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Cat.#:CDK4-664HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CDK4 cell lysate
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Involved Pathway

CDK4 involved in several pathways and played different roles in them. We selected most pathways CDK4 participated on our site, such as ATF-2 transcription factor network, B Cell Receptor Signaling Pathway, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ATF-2 transcription factor network
GADD45A; ATF2; MAPK14; KCNA3; DUSP10; CREB1; RUVBL2; CDK4; HRK; JUN
B Cell Receptor Signaling Pathway
PIK3R1; STAP1; PDK2B; LILRB3; PIK3CG; PDK2; PPP3CB; NEDD9; CMTM3; PLEKHA2
Bladder cancer
DAPK1; BRAF; ARAF; THBS1; EGF; CDK4; DAPK2; VEGFA; FGFR3; MAPK3
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
CDK4; POU2F1; EGR4; DGKA; CTLA4; IRF4; EGR1; EGR3; CSF2; JUNB
Cell Cycle
CDT1; CHEK1; GORASP1; EP300; PKMYT1; KIF20A; CDC14A; NCAPG2; ORC6L; ARPP19A
Cell Cycle, Mitotic
CSNK1E; TUBGCP5; GINS4; TCTN2; ARPP19A; ARPP19B; CENPI; CEP78; STAG2; NCAPD2
Cellular Senescence
LMNB1; HIST3H2BB; HIST1H1D; MINK1; HMGA1B; TERF1; CDKN2D; RING1; CBX8A; H3F3B.1

Protein Function

CDK4 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK4 itself. We selected most functions CDK4 had, and list some proteins which have the same functions with CDK4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein IP6K3; TBK1; KIF27; PFKL; TTLL13; PRKCH; ACTG1; CKMT2; IGF1RA; MAPK14B
Function cyclin binding
Related Protein PTCH1; MDFIC; INCA1; CDKN1A; CDK12; FBXW7; CDK5RAP3; CDK2; HDAC3; PFTK1
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein CDKL5; CDK4; CDK5R1; CCND3; CDK5; CCNK; CDK15; CDK19; CDKL1; CDK12
Function cyclin-dependent protein serine/threonine kinase regulator activity
Related Protein CCNY; CCND1; CCNE1; FAM58A; CCNT2; PSTPIP2; CCNT1; CCNE2; CDK4; CCNT2B
Function protein binding
Related Protein ANAPC4; SEC61B; MTAP; AKR1A1; C3; BCL2L15; C6orf130; POC1A; NCKIPSD; ACVR2B
Function protein complex binding
Related Protein TG; PDZK1; CDH2; SLC27A5; TRAF2; DRD1A; HNF1B; DISC1; SREBF1; ANKRD32

Interacting Protein

CDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK4.
CCND1; CDKN2A

CDK4 Related Articles

Mori, N; Ishikawa, C; et al. Activation of PKC-delta in HTLV-1-infected T cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1609-1618(2015).
Du, ZM; Treiber, D; et al. Use of a Small Molecule Cell Cycle Inhibitor to Control Cell Growth and Improve Specific Productivity and Product Quality of Recombinant Proteins in CHO Cell Cultures. BIOTECHNOLOGY AND BIOENGINEERING 112:141-155(2015).