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CDK4

  • Official Full Name

    cyclin-dependent kinase 4

  • Overview

    The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms

    CDK4; cyclin-dependent kinase 4; CMM3; PSK-J3; cell division protein kinase 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • MYC
  • Myc|DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDK4-191H Recombinant Human CDK4 protein, T7-tagged E.coli T7
Human CDK4-758H Recombinant Human CDK4 protein, GST-tagged Insect Cells GST Met1-Glu303
Human CDK4-1011H Recombinant Human CDK4 Protein, GST-Tagged Wheat Germ GST
Human CDK4-16H Recombinant Human CDK4, His-tagged E.coli His
Human CDK4-1016H Active Recombinant Human CDK4 Protein, His-Tagged Insect Cell His
Human CDK4-11049H Recombinant Human CDK4, GST-tagged E.coli GST 1-303a.a.
Human CDK4/CCND1-633H Recombinant Human CDK4/CCND1, His-tagged Sf9 Insect Cell His
Human CDK4/CCND3-275H Recombinant Human CDK4/CCND3, GST-tagged, Active Sf9 Insect Cell GST
Human CDK4-1000H Recombinant Human Cyclin-Dependent Kinase 4, GST-tagged E.coli GST
Human CDK4-31093TH Recombinant Human Human CDK4 N/A
Human CDK4-7156H Recombinant Human Cyclin-Dependent Kinase 4, His-tagged E.coli His 1-303aa
Human CDK4-938H Recombinant Human CDK4 protein, His/T7-tagged E.coli His/T7 Met1-Glu303
Human CDK4-27905TH Recombinant Human CDK4 E.coli N/A
Human CDK4-1015H Active Recombinant Human CDK4 Protein, GST-Tagged Insect Cell GST
Human CDK4-664HCL Recombinant Human CDK4 cell lysate Insect Cell N/A
Human CDK4-927HFL Recombinant Full Length Human CDK4 Protein, C-Flag-tagged Mammalian cells Flag
Human CDK4-633H Recombinant Human CDK4 Protein, GST-tagged Insect Cell GST
Human CDK4-563H-B Recombinant Human CDK4 Protein Pre-coupled Magnetic Beads HEK293
Human CDK4-3139H Recombinant Human CDK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CDK4-758HAF555 Recombinant Human CDK4 Protein, GST-tagged, Alexa Fluor 555 conjugated Insect Cell GST 528
Human CDK4-758HAF647 Recombinant Human CDK4 Protein, GST-tagged, Alexa Fluor 647 conjugated Insect Cell GST 528
Human CDK4-758HF Recombinant Human CDK4 Protein, GST-tagged, FITC conjugated Insect Cell GST 528
Human CDK4-2208H Recombinant Human CDK4 protein, His-tagged Insect Cell His 2-303aa
Human CDK4-4867HF Active Recombinant Full Length Human CDK4 Protein, GST-tagged Insect (sf21) GST 1-303(end)
Human CDK4-1621HF Active Recombinant Full Length Human CDK4 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-303(end)
Human CDK4-3183HF Recombinant Full Length Human CDK4 Protein, GST-tagged In Vitro Cell Free System GST 211-303 amino acids
Human CDK4-2678H Recombinant Human CDK4 protein, His-tagged E.coli His 2-303aa
Human CDK4-563H Recombinant Human CDK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDK4-758HAF488 Recombinant Human CDK4 Protein, GST-tagged, Alexa Fluor 488 conjugated Insect Cell GST 528
Human CDK4-1073H Recombinant Human CDK4 Protein (Met1-Glu303), His tagged E.coli His Met1-Glu303
Mouse Cdk4-5846M Recombinant Mouse Cdk4 protein, His-tagged E.coli His Tyr6~Leu295 (Accession # P30285)
Mouse CDK4-3203M Recombinant Mouse CDK4 Protein Mammalian Cell His
Mouse CDK4-1525M Recombinant Mouse CDK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cdk4-865M Recombinant Mouse Cdk4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CDK4-1525M-B Recombinant Mouse CDK4 Protein Pre-coupled Magnetic Beads HEK293
Rat CDK4-1304R Recombinant Rat CDK4 Protein Mammalian Cell His
Rat CDK4-962R-B Recombinant Rat CDK4 Protein Pre-coupled Magnetic Beads HEK293
Rat CDK4-962R Recombinant Rat CDK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CDK4-784R Recombinant Rhesus monkey CDK4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CDK4-610R-B Recombinant Rhesus Macaque CDK4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CDK4-610R Recombinant Rhesus Macaque CDK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CDK4-4853Z Recombinant Zebrafish CDK4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDK4 Related Articles
  • CDK4 Related Research Area
  • CDK4 Related Signal Pathway

CDK4 involved in several pathways and played different roles in them. We selected most pathways CDK4 participated on our site, such as ATF-2 transcription factor network, B Cell Receptor Signaling Pathway, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ATF-2 transcription factor networkJUN;DUSP10;CREB1;HRK;POU2F1;CSRP2;RUVBL2;DUSP1;JUND
B Cell Receptor Signaling PathwayPLEKHA1;DOK3;VAV2;BANK1;IKBKB;PIK3R1;PRKCB;CARD11;NFATC3
Bladder cancerRAF1;FGFR3;MMP1;MAP2K2;DAPK3;TYMP;MMP9;E2F1;ARAF
Calcineurin-regulated NFAT-dependent transcription in lymphocytesPOU2F1;EGR1;EGR4;CDK4;IKZF1;CTLA4;CSF2;DGKA;IRF4
Cell CycleRAD50;MCM9;CDK4;CTDNEP1B;FAM175A;MND1;GINS4;SPC25;CCNB1
Cell Cycle, MitoticCSNK2B;CENPH;INCENP;CSNK2A1;KIF2C;BLZF1;CENPQ;NIPBL;BORA
Cellular SenescenceSUZ12;ASF1A;TERF2;PHC2;UBN1;SUZ12A;HIST2H3C;SUZ12B;MAPKAPK2B

CDK4 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK4 itself. We selected most functions CDK4 had, and list some proteins which have the same functions with CDK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingP2RX6;NAV2;RET;MVK;ABCB11;PAK7;ABCA9;DDX19B;NVL
cyclin bindingCDK12;MDFIC;CDK13;USP2;PTCH1;HDAC3;INCA1;CDK14;CDK4
cyclin-dependent protein serine/threonine kinase activityCDK5R1;CDK1;CDKL4;CCND3;CDK10;CDK3;PFTK1;CDKL1;CDK19
cyclin-dependent protein serine/threonine kinase regulator activityCCNY;CCNL1B;CCNL2;CKS1B;CCNT1;PSTPIP2;CCNE1;CCNT2A;CKS2
protein bindingEFTUD2;DOT1L;IGFBP7;NHLRC1;KIAA1967;WDR92;THRA;MTUS2;TTC30B
protein complex bindingNCKAP1L;DISC1;PPP1R9B;ERCC8;RANBP2;CDKN1B;C8G;BCAP31;Apba1

CDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK4.

CCND1; CDKN2A

Mori, N; Ishikawa, C; et al. Activation of PKC-delta in HTLV-1-infected T cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1609-1618(2015).
Du, ZM; Treiber, D; et al. Use of a Small Molecule Cell Cycle Inhibitor to Control Cell Growth and Improve Specific Productivity and Product Quality of Recombinant Proteins in CHO Cell Cultures. BIOTECHNOLOGY AND BIOENGINEERING 112:141-155(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any potential challenges in targeting CDK4 for cancer therapy? 11/24/2022

Resistance to CDK4 inhibitors and the need for patient stratification are some of the challenges in using CDK4 as a therapeutic target.

Can CDK4 be targeted for cancer therapy? 06/16/2022

Yes, CDK4 is a target for cancer therapy, and drugs that inhibit CDK4 have been developed for the treatment of specific cancers.

How is CDK4 clinically relevant? 06/30/2020

CDK4 is clinically relevant because it plays a crucial role in the development and progression of various cancers.

Which cancers are commonly associated with CDK4 overactivity? 06/19/2020

CDK4 overactivity is commonly associated with breast cancer, melanoma, and liposarcoma.

How does CDK4 relate to cell senescence? 05/31/2016

CDK4 can promote cell senescence, a state of irreversible growth arrest, which has implications in cancer therapy.

Customer Reviews (3)

Write a review
Reviews
02/18/2023

    Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the CDK4 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.

    02/16/2020

      They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the CDK4 protein.

      05/29/2018

        The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.

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