CDK4

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CDK4

Official Full Name cyclin-dependent kinase 4
Background The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Synonyms CDK4; cyclin-dependent kinase 4; CMM3; PSK-J3; cell division protein kinase 4;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDK4-633H Recombinant Human CDK4 Protein, GST-tagged Insect Cell GST
    Mouse Cdk4-865M Recombinant Mouse Cdk4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CDK4/CCND1-633H Recombinant Human CDK4/CCND1, His-tagged Sf9 Insect Cell His
    Human CDK4/CCND3-275H Recombinant Human CDK4/CCND3, GST-tagged, Active Sf9 Insect Cell GST
    Human CDK4-1000H Recombinant Human Cyclin-Dependent Kinase 4, GST-tagged E.coli GST
    Human CDK4-1011H Recombinant Human CDK4 Protein, GST-Tagged Wheat Germ GST
    Human CDK4-1015H Recombinant Human CDK4 Protein, GST-Tagged Insect Cell GST
    Human CDK4-1016H Recombinant Human CDK4 Protein, His-Tagged Insect Cell His
    Human CDK4-11049H Recombinant Human CDK4, GST-tagged E.coli GST
    Human CDK4-16H Recombinant Human CDK4, His-tagged E.coli His
    Human CDK4-191H Recombinant Human CDK4 protein, T7-tagged E.coli T7
    Human CDK4-27905TH Recombinant Human CDK4 E.coli N/A
    Human CDK4-31093TH Recombinant Human Human CDK4 N/A
    Human CDK4-3139H Recombinant Human CDK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CDK4-664HCL Recombinant Human CDK4 cell lysate Insect Cell N/A
    Human CDK4-7156H Recombinant Human Cyclin-Dependent Kinase 4, His-tagged E.coli His
    Human CDK4-758H Recombinant Human CDK4, GST tagged Insect Cell GST
    Human CDK4-938H Recombinant Human CDK4 protein, His/T7-tagged E.coli His/T7
    Mouse CDK4-3203M Recombinant Mouse CDK4 Protein Mammalian Cell His
    Mouse Cdk4-5846M Recombinant Mouse Cdk4 protein, His-tagged E.coli His
    Rat CDK4-1304R Recombinant Rat CDK4 Protein Mammalian Cell His
    Rhesus Macaque CDK4-784R Recombinant Rhesus monkey CDK4 Protein, His-tagged Mammalian Cell His
    Zebrafish CDK4-4853Z Recombinant Zebrafish CDK4 Mammalian Cell His

    CDK4 involved in several pathways and played different roles in them. We selected most pathways CDK4 participated on our site, such as ATF-2 transcription factor network, B Cell Receptor Signaling Pathway, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ATF-2 transcription factor network GADD45A; CREB1; POU2F1; CBFB; CDK4; DDIT3; ATF2; HRK; MAPK14; JUN
    B Cell Receptor Signaling Pathway cgr2b; MAPK1; PILRB; CR2; DUSP4; FCGR2B; PIK3CA; NRAS; CD22; DOK1
    Bladder cancer E2F3; MYC; MDM2; TRP53; IL-8; E2F1; EGF; MAPK3; ARAF; DAPK3
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes EGR1; EGR3; CDK4; IKZF1; IRF4; CTLA4; DGKA; EGR2; POU2F1; JUNB
    Cell Cycle CDC14A; CEP63; WEE2; HIST3H2BB; UIMC1; MAD2L2; CDC14B; CCP110; ORC5; E2F4
    Cell Cycle, Mitotic FOXM1; CDK11A; DULLARD; E2F2; TUBGCP3; ENSAB; SKA2; MIS12; POLD3; PMF1
    Cellular Senescence UBN1; HIRA; SUZ12B; CBX8; KDM6B; RNF2; AGO1; KAT5; CABIN1; HIST2H3C

    CDK4 has several biochemical functions, for example, ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK4 itself. We selected most functions CDK4 had, and list some proteins which have the same functions with CDK4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SRX1; MAP2K2B; ADCY6; CHD7; UBE2J1; YTHDC2; CKMT1; DDX6; MCM2; EPHB1
    cyclin binding INCA1; CDK14; CDK4; PFTK1; CDK2; CDK13; CDK6; HDAC3; CDKN1A; USP2
    cyclin-dependent protein serine/threonine kinase activity CDK5R1; CDK3; NAT1; CDK19; CDK11A; CDK18; ICK; CDK13; CDK17; PFTK1
    cyclin-dependent protein serine/threonine kinase regulator activity CCNT2B; CKS1B; CCNT2A; CCNE1; CCNL1; CCNE2; CCNL2; CCND1; CCNY; FAM58A
    protein binding TPP1; TPD52L2; PITPNC1; AGBL4; CD74; CLU; IFIH1; RIBC2; CCDC146; TACC3
    protein complex binding RAN; PGAM5; ABI2; WRN; NOG; STK11; DRD1; ST13; LRP2; RELA

    CDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK4.

    CCND1; CDKN2A

    Mori, N; Ishikawa, C; et al. Activation of PKC-delta in HTLV-1-infected T cells. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1609-1618(2015).
    Du, ZM; Treiber, D; et al. Use of a Small Molecule Cell Cycle Inhibitor to Control Cell Growth and Improve Specific Productivity and Product Quality of Recombinant Proteins in CHO Cell Cultures. BIOTECHNOLOGY AND BIOENGINEERING 112:141-155(2015).

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